Thymosin alpha1 inhibits mammary carcinogenesis in Fisher rats.

Moody TW, Tuthill C, Badamchian M, Goldstein AL

Peptides1 May 2002Cited by 19 (Europe PMC)

PMID12084534DOI10.1016/s0196-9781(02)00025-6PepBankPUB-12084534

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Efficacy outcome
In Fisher rats given N-nitrosomethylurea, daily subcutaneous thymosin alpha1 (10 microg) reduced mammary carcinoma incidence.
In plain wordsIn rats given a cancer-causing chemical, daily thymosin alpha1 lowered the number that developed mammary cancer.
Peptide
Thymosin alpha-1
Outcome
DecreaseMammary carcinoma incidence
Study
Fisher ratn: not reported in source
NMU-induced mammary carcinogenesis
Outcome group
Tumor growth · Cancer
Studied dose
10 microg · subcutaneousAs given in this study (Fisher rat).
Source sentences
Summary
Daily administration of Talpha1 (10 microg, s.c.) reduced mammary carcinoma incidence
1 context sentence(design, population, supporting numbers)
Summary · context
Mammary carcinomas were observed 3 months after N-nitrosomethylurea (NMU) injection (10mg, i.p.) into Fisher rats.
Report a problemFND-1208453401
02AnimalAnimal study (in vivo)Efficacy outcome
In Fisher rats given N-nitrosomethylurea, daily subcutaneous thymosin alpha1 (10 microg) prolonged survival time.
In plain wordsIn rats given a cancer-causing chemical, daily thymosin alpha1 lengthened survival.
Peptide
Thymosin alpha-1
Outcome
IncreaseSurvival time
Study
Fisher ratn: not reported in source
NMU-induced mammary carcinogenesis
Outcome group
Mortality · Cancer
Studied dose
10 microg · subcutaneousAs given in this study (Fisher rat).
Source sentences
Summary
Daily administration of Talpha1 (10 microg, s.c.) reduced mammary carcinoma incidence and prolonged survival time.
1 context sentence(design, population, supporting numbers)
Summary · context
Mammary carcinomas were observed 3 months after N-nitrosomethylurea (NMU) injection (10mg, i.p.) into Fisher rats.
Report a problemFND-1208453402
03AnimalAnimal study (in vivo)Mechanism
In Fisher rats, animals treated with thymosin alpha1 had a significantly greater blood white cell density than control rats.
In plain wordsIn rats, those given thymosin alpha1 had more white blood cells than untreated control rats.
Peptide
Thymosin alpha-1
Outcome
IncreaseBlood white cell density
Study
Fisher ratn: not reported in source
NMU-induced mammary carcinogenesis
Comparator
Control Fisher rats
Outcome group
Immune response · Immune and inflammation
Studied dose
10 microg · subcutaneousAs given in this study (Fisher rat).
Source sentences
Summary
Animals treated with exogenous Talpha1 had a significantly greater blood white cell density than control Fisher rats.
1 context sentence(design, population, supporting numbers)
Summary · context
Mammary carcinomas were observed 3 months after N-nitrosomethylurea (NMU) injection (10mg, i.p.) into Fisher rats.
Report a problemFND-1208453403

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 3Current
10 Oct 2026, 08:55 UTC
Study results updated
Version 2
9 Oct 2026, 03:03 UTC
Study data updated · source update from Europe PMC
Version 1
9 Oct 2026, 03:02 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

Journal Article

MeSH terms

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