Insulin-like growth factor-I and analogues increase growth in artificially-reared neonatal pigs.

Dunshea FR, Chung CS, Owens PC, Ballard JF, Walton PE

The British journal of nutrition1 Jun 2002Cited by 9 (Europe PMC)

PMID12067429DOI10.1079/bjnbjn2002574PepBankPUB-12067429

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study9

5 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Efficacy outcome
In neonatal pigs, milk intake was apparently greater with IGF-I than with LR3IGF-I, but the difference was not significant.
In plain wordsIn young pigs, milk intake with IGF-I was a little higher than with LR3IGF-I, but the difference was not significant.
Peptide
IGF-1 LR3
Outcome
No significant changeMilk intake, LR3IGF-I versus IGF-I, Expt 1
Study
pign: not reported in source
Artificially-reared neonatal pigs
Comparator
IGF-I
Outcome group
Appetite and food intake · Metabolic and weight
Studied dose
2, 4 or 8 microg/h · infusion · 8 daysAs given in this study (pig).
Measurements
Milk intake, IGF-I
920 g/d
IGF-I
Milk intake, LR3IGF-I
898 g/d
LR3IGF-I
Source sentences
Summary
867 g/d, P=0.027), with an apparently greater milk intake by the pigs infused with IGF-I compared with LR3IGF-I (920 v. 898 g/d, P=0.12).
1 context sentence(design, population, supporting numbers)
Summary · context
Expt 1 involved forty-two (2 kg initial weight) pigs infused with either control, IGF-I (2, 4 or 8 microg/h) or LR3IGF-I (2, 4 or 8 microg/h) infusions for 8 d.
Report a problemFND-1206742904
02AnimalAnimal study (in vivo)Efficacy outcome
In neonatal pigs, infusion of LR3IGF-I decreased plasma IGF-I concentrations.
In plain wordsIn young pigs, infusing LR3IGF-I lowered the pig's own IGF-I level in the blood.
Peptide
IGF-1 LR3
Outcome
DecreasePlasma IGF-I concentration, Expt 1
Study
pign: not reported in source
Artificially-reared neonatal pigs
Comparator
Control
Outcome group
Growth hormone and IGF-1 · Endocrine and hormones
Studied dose
2, 4 or 8 microg/h · infusion · 8 daysAs given in this study (pig).
Source sentences
Summary
Infusion of LR3IGF-I decreased plasma IGF-I concentrations, but had no effect on plasma IGF-II concentrations.
1 context sentence(design, population, supporting numbers)
Summary · context
Expt 1 involved forty-two (2 kg initial weight) pigs infused with either control, IGF-I (2, 4 or 8 microg/h) or LR3IGF-I (2, 4 or 8 microg/h) infusions for 8 d.
Report a problemFND-1206742905
03AnimalAnimal study (in vivo)Efficacy outcome
In neonatal pigs, infusion of LR3IGF-I had no effect on plasma IGF-II concentrations.
In plain wordsIn young pigs, infusing LR3IGF-I did not change IGF-II levels in the blood.
Peptide
IGF-1 LR3
Outcome
No significant changePlasma IGF-II concentration, Expt 1
Study
pign: not reported in source
Artificially-reared neonatal pigs
Comparator
Control
Outcome group
Growth hormone and IGF-1 · Endocrine and hormones
Studied dose
2, 4 or 8 microg/h · infusion · 8 daysAs given in this study (pig).
Source sentences
Summary
Infusion of LR3IGF-I decreased plasma IGF-I concentrations, but had no effect on plasma IGF-II concentrations.
1 context sentence(design, population, supporting numbers)
Summary · context
Expt 1 involved forty-two (2 kg initial weight) pigs infused with either control, IGF-I (2, 4 or 8 microg/h) or LR3IGF-I (2, 4 or 8 microg/h) infusions for 8 d.
Report a problemFND-1206742906
04AnimalAnimal study (in vivo)Efficacy outcome
In neonatal pigs, LR3IGF-I infusion had no effect on daily weight gain over the first 9 days of Expt 2.
In plain wordsIn young pigs, LR3IGF-I did not change daily weight gain over the first 9 days.
Peptide
IGF-1 LR3
Outcome
No significant changeDaily weight gain, first 9 days, Expt 2
Study
pign: not reported in source
Artificially-reared neonatal pigs
Comparator
Control saline
Outcome group
Body weight · Metabolic and weight
Studied dose
8 microg/h · infusion · 9 daysAs given in this study (pig).
Source sentences
Summary
In Expt 2, neither IGF-I nor LR3IGF-I infusion had any effect upon daily weight gain over the first 9 d of the study.
1 context sentence(design, population, supporting numbers)
Summary · context
Expt 2 involved eighteen pigs (2 kg initial weight) treated with control saline, IGF-I (8 microg/h) or LR3IGF-I (8 microg/h) infusions.
Report a problemFND-1206742907
05AnimalAnimal study (in vivo)Efficacy outcome
In neonatal pigs, daily weight gain over the second 9 days of Expt 2 was higher with LR3IGF-I infusion than with control.
In plain wordsIn young pigs, LR3IGF-I raised daily weight gain over the second 9 days compared with control.
Peptide
IGF-1 LR3
Outcome
IncreaseDaily weight gain, second 9 days, Expt 2
Study
pign: not reported in source
Artificially-reared neonatal pigs
Comparator
Control saline
Outcome group
Body weight · Metabolic and weight
Studied dose
16 microg/h · infusion · 9 daysAs given in this study (pig).
Measurements
Daily weight gain, LR3IGF-I
457 g/d
LR3IGF-I second 9 d
Daily weight gain, control
386 g/d
control second 9 d
Source sentences
Summary
However, over the second 9 d of the study, daily weight gain was increased in LR3IGF-I-infused pigs (457 v. 386 g/d, P<0.01), but not in pigs infused with IGF-I (413 v.
1 context sentence(design, population, supporting numbers)
Summary · context
After 9 d an additional pump was inserted to increase the infusion rates of each of the growth factors (16 microg/h) for a further 9 d.
Report a problemFND-1206742908

Studies that did not test the peptide alone4

In this study, IGF-1 LR3 was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking IGF-1 LR3.

06AnimalNot a test of IGF-1 LR3 aloneAnimal study (in vivo)Efficacy outcome
In neonatal pigs, infusion of IGF-I or LR3IGF-I pooled had no overall effect on daily weight gain in Expt 1.
In plain wordsIn young pigs, infusing IGF-I or LR3IGF-I, taken together, did not change daily weight gain in the first experiment.
Peptide
IGF-1 LR3
Outcome
No significant changeDaily weight gain, Expt 1
Study
pign = 42
Artificially-reared neonatal pigs
Comparator
Control
Outcome group
Body weight · Metabolic and weight
Source sentences
Summary
In Expt 1 there was no overall effect of growth factors on daily weight gain or slaughter weight.
1 context sentence(design, population, supporting numbers)
Summary · context
Expt 1 involved forty-two (2 kg initial weight) pigs infused with either control, IGF-I (2, 4 or 8 microg/h) or LR3IGF-I (2, 4 or 8 microg/h) infusions for 8 d.
In this study, IGF-1 LR3 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking IGF-1 LR3.
Report a problemFND-1206742901
07AnimalNot a test of IGF-1 LR3 aloneAnimal study (in vivo)Efficacy outcome
In neonatal pigs, infusion of IGF-I or LR3IGF-I pooled had no overall effect on slaughter weight in Expt 1.
In plain wordsIn young pigs, infusing IGF-I or LR3IGF-I, taken together, did not change slaughter weight in the first experiment.
Peptide
IGF-1 LR3
Outcome
No significant changeSlaughter weight, Expt 1
Study
pign = 42
Artificially-reared neonatal pigs
Comparator
Control
Outcome group
Body weight · Metabolic and weight
Source sentences
Summary
In Expt 1 there was no overall effect of growth factors on daily weight gain or slaughter weight.
1 context sentence(design, population, supporting numbers)
Summary · context
Expt 1 involved forty-two (2 kg initial weight) pigs infused with either control, IGF-I (2, 4 or 8 microg/h) or LR3IGF-I (2, 4 or 8 microg/h) infusions for 8 d.
In this study, IGF-1 LR3 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking IGF-1 LR3.
Report a problemFND-1206742902
08AnimalNot a test of IGF-1 LR3 aloneAnimal study (in vivo)Efficacy outcome
In neonatal pigs, milk intake was greater in pigs infused with growth factors (IGF-I and LR3IGF-I pooled) than in controls in Expt 1.
In plain wordsIn young pigs, those infused with IGF-I or LR3IGF-I, taken together, drank more milk than controls.
Peptide
IGF-1 LR3
Outcome
IncreaseMilk intake, Expt 1
Study
pign = 42
Artificially-reared neonatal pigs
Comparator
Control
Outcome group
Appetite and food intake · Metabolic and weight
Measurements
Milk intake, growth factors
909 g/d
pooled growth factors
Milk intake, comparator
867 g/d
control
Source sentences
Summary
However, milk intake was greater in pigs infused with growth factors (909 v. 867 g/d, P=0.027), with an apparently greater milk intake by the pigs infused with IGF-I compared with LR3IGF-I (920 v.
1 context sentence(design, population, supporting numbers)
Summary · context
Expt 1 involved forty-two (2 kg initial weight) pigs infused with either control, IGF-I (2, 4 or 8 microg/h) or LR3IGF-I (2, 4 or 8 microg/h) infusions for 8 d.
In this study, IGF-1 LR3 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking IGF-1 LR3.
Report a problemFND-1206742903
09AnimalNot a test of IGF-1 LR3 aloneAnimal study (in vivo)Efficacy outcome
In neonatal pigs, milk intake over the second half of Expt 2 was greater in pigs infused with growth factors (IGF-I and LR3IGF-I pooled) than in controls.
In plain wordsIn young pigs, those infused with IGF-I or LR3IGF-I, taken together, drank more milk in the second half than controls.
Peptide
IGF-1 LR3
Outcome
IncreaseMilk intake, second half, Expt 2
Study
pign = 18
Artificially-reared neonatal pigs
Comparator
Control saline
Outcome group
Appetite and food intake · Metabolic and weight
Measurements
Milk intake, growth factors
3407 g/d
pooled growth factors
Milk intake, comparator
2905 g/d
control
Source sentences
Summary
Milk intake was not different during the first 9 d of the study but was significantly greater in pigs infused with growth factors over the second half of the study (3407 v. 2905 g/d, P<0.01).
1 context sentence(design, population, supporting numbers)
Summary · context
Expt 2 involved eighteen pigs (2 kg initial weight) treated with control saline, IGF-I (8 microg/h) or LR3IGF-I (8 microg/h) infusions.
In this study, IGF-1 LR3 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking IGF-1 LR3.
Report a problemFND-1206742909

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
13 Oct 2026, 21:44 UTC
Study results updated
Version 1
13 Oct 2026, 16:31 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

Journal Article

MeSH terms

PepBank is a research reference. Talk to a doctor before you use any peptide.