Downregulation of glucocorticoid receptors of liver cytosols and the role of the inflammatory cytokines in pathological stress in scalded rats.

Liu DH, Su YP, Zhang W, Lou SF, Ran XZ, Gao JS, Cheng TM

Burns : journal of the International Society for Burn Injuries1 Jun 2002Cited by 14 (Europe PMC)

PMID12052369DOI10.1016/s0305-4179(02)00011-6PepBankPUB-12052369

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

5 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Efficacy outcome
In scalded rats, KPV peptide injection might prevent the decrease in glucocorticoid receptor binding capacity in hepatic cytosol 12 h after scald.
In plain wordsIn scalded rats, KPV injections might stop the drop in liver glucocorticoid receptor binding.
Peptide
KPV
Outcome
IncreaseGlucocorticoid receptor binding capacity (Rt) in hepatic cytosol
Study
ratn: not reported in source
Wistar rats with 35% immersion scald
Outcome group
Receptor activity and mechanism · Endocrine and hormones
Studied dose
Dose not stated
Measurements
GR binding capacity (Rt)
263.46 fmol/mg of protein
KPV peptide, scalded rats
Source sentences
Summary
The injections of anti-rat TNFalpha (257.80+/-12.82fmol/mg of protein), IL-1beta antibody (254.46+/-21.21fmol/mg of protein), alpha-melanocyte-stimulating hormone (278.32+/-7.76fmol/mg of protein) and KPV peptide (263.46+/-17.46fmol/mg of protein) might prevent the Rt of GR from decreasing in hepati…
1 context sentence(design, population, supporting numbers)
Summary · context
Male Wistar rats (weight range, 180-200g) received a 35% total body surface area immersion scald and were randomly divided to receive either tumor necrosis factor alpha (TNFalpha), interleukin-1beta (IL-1beta), polyclonal antibody (pAb), alpha-MSH, Ac-D-Lys-L-Pro-D-Val (KPV peptide), or saline (control).
Report a problemFND-1205236901
02AnimalAnimal study (in vivo)Efficacy outcome
In scalded rats, KPV administration might attenuate the scald-induced increase in plasma IL-1beta.
In plain wordsIn scalded rats, KPV might reduce the rise in the inflammatory signal IL-1beta.
Peptide
KPV
Outcome
DecreasePlasma IL-1beta after scald
Study
ratn: not reported in source
Wistar rats with 35% immersion scald
Outcome group
Inflammation markers · Immune and inflammation
Studied dose
Dose not stated
Source sentences
Summary
Scald-induced robust increases in plasma IL-1beta (214.08+/-27.25pg/ml), TNFalpha (111.18+/-23.97pg/ml), IL-10 (177.50+/-15.79pg/ml) and corticosterone (2680+/-443.23ng/ml) levels after 12h. The administration of TNFalpha, IL-1beta pAb, alpha-MSH and KPV might attenuate these increases.
1 context sentence(design, population, supporting numbers)
Summary · context
Male Wistar rats (weight range, 180-200g) received a 35% total body surface area immersion scald and were randomly divided to receive either tumor necrosis factor alpha (TNFalpha), interleukin-1beta (IL-1beta), polyclonal antibody (pAb), alpha-MSH, Ac-D-Lys-L-Pro-D-Val (KPV peptide), or saline (control).
Report a problemFND-1205236902
03AnimalAnimal study (in vivo)Efficacy outcome
In scalded rats, KPV administration might attenuate the scald-induced increase in plasma TNF-alpha.
In plain wordsIn scalded rats, KPV might reduce the rise in the inflammatory signal TNF-alpha.
Peptide
KPV
Outcome
DecreasePlasma TNF-alpha after scald
Study
ratn: not reported in source
Wistar rats with 35% immersion scald
Outcome group
Inflammation markers · Immune and inflammation
Studied dose
Dose not stated
Source sentences
Summary
Scald-induced robust increases in plasma IL-1beta (214.08+/-27.25pg/ml), TNFalpha (111.18+/-23.97pg/ml), IL-10 (177.50+/-15.79pg/ml) and corticosterone (2680+/-443.23ng/ml) levels after 12h. The administration of TNFalpha, IL-1beta pAb, alpha-MSH and KPV might attenuate these increases.
1 context sentence(design, population, supporting numbers)
Summary · context
Male Wistar rats (weight range, 180-200g) received a 35% total body surface area immersion scald and were randomly divided to receive either tumor necrosis factor alpha (TNFalpha), interleukin-1beta (IL-1beta), polyclonal antibody (pAb), alpha-MSH, Ac-D-Lys-L-Pro-D-Val (KPV peptide), or saline (control).
Report a problemFND-1205236903
04AnimalAnimal study (in vivo)Efficacy outcome
In scalded rats, KPV administration might attenuate the scald-induced increase in plasma IL-10.
In plain wordsIn scalded rats, KPV might reduce the rise in the immune signal IL-10.
Peptide
KPV
Outcome
DecreasePlasma IL-10 after scald
Study
ratn: not reported in source
Wistar rats with 35% immersion scald
Outcome group
Inflammation markers · Immune and inflammation
Studied dose
Dose not stated
Source sentences
Summary
Scald-induced robust increases in plasma IL-1beta (214.08+/-27.25pg/ml), TNFalpha (111.18+/-23.97pg/ml), IL-10 (177.50+/-15.79pg/ml) and corticosterone (2680+/-443.23ng/ml) levels after 12h. The administration of TNFalpha, IL-1beta pAb, alpha-MSH and KPV might attenuate these increases.
1 context sentence(design, population, supporting numbers)
Summary · context
Male Wistar rats (weight range, 180-200g) received a 35% total body surface area immersion scald and were randomly divided to receive either tumor necrosis factor alpha (TNFalpha), interleukin-1beta (IL-1beta), polyclonal antibody (pAb), alpha-MSH, Ac-D-Lys-L-Pro-D-Val (KPV peptide), or saline (control).
Report a problemFND-1205236904
05AnimalAnimal study (in vivo)Efficacy outcome
In scalded rats, KPV administration might attenuate the scald-induced increase in plasma corticosterone.
In plain wordsIn scalded rats, KPV might reduce the rise in the stress hormone corticosterone.
Peptide
KPV
Outcome
DecreasePlasma corticosterone after scald
Study
ratn: not reported in source
Wistar rats with 35% immersion scald
Outcome group
Stress hormones · Endocrine and hormones
Studied dose
Dose not stated
Source sentences
Summary
Scald-induced robust increases in plasma IL-1beta (214.08+/-27.25pg/ml), TNFalpha (111.18+/-23.97pg/ml), IL-10 (177.50+/-15.79pg/ml) and corticosterone (2680+/-443.23ng/ml) levels after 12h. The administration of TNFalpha, IL-1beta pAb, alpha-MSH and KPV might attenuate these increases.
1 context sentence(design, population, supporting numbers)
Summary · context
Male Wistar rats (weight range, 180-200g) received a 35% total body surface area immersion scald and were randomly divided to receive either tumor necrosis factor alpha (TNFalpha), interleukin-1beta (IL-1beta), polyclonal antibody (pAb), alpha-MSH, Ac-D-Lys-L-Pro-D-Val (KPV peptide), or saline (control).
Report a problemFND-1205236905

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 3Current
9 Oct 2026, 18:17 UTC
Study results updated
Version 2
9 Oct 2026, 03:03 UTC
Study data updated · source update from Europe PMC
Version 1
9 Oct 2026, 02:56 UTC
First added · source update from Europe PMC

Subjects

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