Inhibitory effect of peptide Epitalon on colon carcinogenesis induced by 1,2-dimethylhydrazine in rats.

Anisimov VN, Khavinson VKh, Popovich IG, Zabezhinski MA

Cancer letters1 Sept 2002Cited by 13 (Europe PMC)

PMID12049808DOI10.1016/s0304-3835(02)00090-3PepBankPUB-12049808

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study7

7 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Efficacy outcome
In DMH-treated rats, Epitalon given during the whole experiment lowered the number of colon tumors per rat versus saline.
In plain wordsIn rats given a colon carcinogen, Epitalon throughout the study led to fewer colon tumors than saline.
Peptide
Epitalon
Outcome
DecreaseTotal colon tumors per rat, Epitalon during whole experiment (group 2)
Study
ratn: not reported in source
DMH-induced colon carcinogenesis in LIO rats
Comparator
Saline (group 1)
Outcome group
Tumor growth · Cancer
Studied dose
1 microg · subcutaneous · during the whole experimentAs given in this study (rat).
Measurements
Colon tumors per rat
2.7 tumors/rat
group 2
Colon tumors per rat
4.1 tumors/rat
group 1 control
Source sentences
Summary
The number of total colon tumors per rat was 4.1; 2.7; 3.7; 2.9 in groups 1, 2, 3, 4, respectively (the difference in groups 2 and 4 compared with group 1 is significant).
3 context sentences(design, population, supporting numbers)
Summary · context
Additionally, 5 days a week, some of the rats were given subcutaneous injections of saline at a dose of 0.1 ml during the whole experiment (group 1, control) or Epitalon at a single dose of 1 microg during the whole experiment (group 2), Epitalon after termination of carcinogen injections (group 3)…
Summary · context
The effect of synthetic pineal peptide Epitalon (Ala-Glu-Asp-Gly) on colon carcinogenesis was firstly studied in rats.
Summary · context
Eighty 2-month-old outbred male LIO rats were subdivided into four groups and were weekly exposed to five subcutaneous injections of 1,2-dimethylhydrazine (DMH) at a single dose of 21 mg/kg body weight.
Report a problemFND-1204980801
02AnimalAnimal study (in vivo)Efficacy outcome
In DMH-treated rats, Epitalon given during DMH exposure lowered the number of colon tumors per rat versus saline.
In plain wordsIn rats given a colon carcinogen, Epitalon during carcinogen exposure led to fewer colon tumors than saline.
Peptide
Epitalon
Outcome
DecreaseTotal colon tumors per rat, Epitalon during DMH exposure (group 4)
Study
ratn: not reported in source
DMH-induced colon carcinogenesis in LIO rats
Comparator
Saline (group 1)
Outcome group
Tumor growth · Cancer
Studied dose
1 microg · subcutaneous · during the period of DMH exposureAs given in this study (rat).
Measurements
Colon tumors per rat
2.9 tumors/rat
group 4
Colon tumors per rat
4.1 tumors/rat
group 1 control
Source sentences
Summary
The number of total colon tumors per rat was 4.1; 2.7; 3.7; 2.9 in groups 1, 2, 3, 4, respectively (the difference in groups 2 and 4 compared with group 1 is significant).
4 context sentences(design, population, supporting numbers)
Summary · context
In group 4, the mean number of tumors per rat was significantly decreased, too.
Summary · context
Additionally, 5 days a week, some of the rats were given subcutaneous injections of saline at a dose of 0.1 ml during the whole experiment (group 1, control) or Epitalon at a single dose of 1 microg during the whole experiment (group 2), Epitalon after termination of carcinogen injections (group 3)…
Summary · context
The effect of synthetic pineal peptide Epitalon (Ala-Glu-Asp-Gly) on colon carcinogenesis was firstly studied in rats.
Summary · context
Eighty 2-month-old outbred male LIO rats were subdivided into four groups and were weekly exposed to five subcutaneous injections of 1,2-dimethylhydrazine (DMH) at a single dose of 21 mg/kg body weight.
Report a problemFND-1204980802
03AnimalAnimal study (in vivo)Efficacy outcome
In DMH-treated rats, Epitalon given after the carcinogen injections did not significantly change the number of colon tumors per rat versus saline.
In plain wordsIn rats given a colon carcinogen, Epitalon started after the carcinogen did not significantly change tumor numbers compared with saline.
Peptide
Epitalon
Outcome
No significant changeTotal colon tumors per rat, Epitalon after DMH (group 3)
Study
ratn: not reported in source
DMH-induced colon carcinogenesis in LIO rats
Comparator
Saline (group 1)
Outcome group
Tumor growth · Cancer
Studied dose
1 microg · subcutaneous · after termination of carcinogen injectionsAs given in this study (rat).
Measurements
Colon tumors per rat
3.7 tumors/rat
group 3
Colon tumors per rat
4.1 tumors/rat
group 1 control
Source sentences
Summary
The number of total colon tumors per rat was 4.1; 2.7; 3.7; 2.9 in groups 1, 2, 3, 4, respectively (the difference in groups 2 and 4 compared with group 1 is significant).
3 context sentences(design, population, supporting numbers)
Summary · context
Additionally, 5 days a week, some of the rats were given subcutaneous injections of saline at a dose of 0.1 ml during the whole experiment (group 1, control) or Epitalon at a single dose of 1 microg during the whole experiment (group 2), Epitalon after termination of carcinogen injections (group 3)…
Summary · context
The effect of synthetic pineal peptide Epitalon (Ala-Glu-Asp-Gly) on colon carcinogenesis was firstly studied in rats.
Summary · context
Eighty 2-month-old outbred male LIO rats were subdivided into four groups and were weekly exposed to five subcutaneous injections of 1,2-dimethylhydrazine (DMH) at a single dose of 21 mg/kg body weight.
Report a problemFND-1204980803
04AnimalAnimal study (in vivo)Efficacy outcome
In DMH-treated rats, colon tumors were smaller with Epitalon during the whole experiment than in control animals.
In plain wordsIn rats given a colon carcinogen, colon tumors were smaller with Epitalon throughout the study than in control animals.
Peptide
Epitalon
Outcome
DecreaseColon tumor size, group 2
Study
ratn: not reported in source
DMH-induced colon carcinogenesis in LIO rats
Comparator
Saline (group 1)
Outcome group
Tumor growth · Cancer
Studied dose
1 microg · subcutaneous · during the whole experimentAs given in this study (rat).
Source sentences
Summary
In rats from group 2, colon tumors were smaller than in control animals.
3 context sentences(design, population, supporting numbers)
Summary · context
Additionally, 5 days a week, some of the rats were given subcutaneous injections of saline at a dose of 0.1 ml during the whole experiment (group 1, control) or Epitalon at a single dose of 1 microg during the whole experiment (group 2), Epitalon after termination of carcinogen injections (group 3)…
Summary · context
The effect of synthetic pineal peptide Epitalon (Ala-Glu-Asp-Gly) on colon carcinogenesis was firstly studied in rats.
Summary · context
Eighty 2-month-old outbred male LIO rats were subdivided into four groups and were weekly exposed to five subcutaneous injections of 1,2-dimethylhydrazine (DMH) at a single dose of 21 mg/kg body weight.
Report a problemFND-1204980804
05AnimalAnimal study (in vivo)Efficacy outcome
In DMH-treated rats, Epitalon during the whole experiment significantly decreased the incidence and multiplicity of tumors in the ascending and descending colon versus group 1.
In plain wordsIn rats given a colon carcinogen, Epitalon throughout the study reduced how often and how many colon tumors appeared compared with saline.
Peptide
Epitalon
Outcome
DecreaseIncidence and multiplicity of tumors in ascending and descending colon, group 2
Study
ratn: not reported in source
DMH-induced colon carcinogenesis in LIO rats
Comparator
Saline (group 1)
Outcome group
Tumor growth · Cancer
Studied dose
1 microg · subcutaneous · during the whole experimentAs given in this study (rat).
Source sentences
Summary
In group 2, the incidence, as well the multiplicity of tumors in ascending and descending colon, were significantly decreased in comparison with group 1.
3 context sentences(design, population, supporting numbers)
Summary · context
Additionally, 5 days a week, some of the rats were given subcutaneous injections of saline at a dose of 0.1 ml during the whole experiment (group 1, control) or Epitalon at a single dose of 1 microg during the whole experiment (group 2), Epitalon after termination of carcinogen injections (group 3)…
Summary · context
The effect of synthetic pineal peptide Epitalon (Ala-Glu-Asp-Gly) on colon carcinogenesis was firstly studied in rats.
Summary · context
Eighty 2-month-old outbred male LIO rats were subdivided into four groups and were weekly exposed to five subcutaneous injections of 1,2-dimethylhydrazine (DMH) at a single dose of 21 mg/kg body weight.
Report a problemFND-1204980805
06AnimalAnimal study (in vivo)Efficacy outcome
In DMH-treated rats, Epitalon showed only a trend to decrease the number of rectal tumors.
In plain wordsIn rats given a colon carcinogen, Epitalon showed only a trend toward fewer rectal tumors, not a clear effect.
Peptide
Epitalon
Outcome
No significant changeRectal tumor number (groups 2, 3, 4)
Study
ratn: not reported in source
DMH-induced colon carcinogenesis in LIO rats
Comparator
Saline (group 1)
Outcome group
Tumor growth · Cancer
Studied dose
1 microg · subcutaneousAs given in this study (rat).
Source sentences
Summary
A trend to decrease the number of tumors in the rectum in rats from groups 2, 3 and 4, treated with Epitalon was found.
2 context sentences(design, population, supporting numbers)
Summary · context
The effect of synthetic pineal peptide Epitalon (Ala-Glu-Asp-Gly) on colon carcinogenesis was firstly studied in rats.
Summary · context
Eighty 2-month-old outbred male LIO rats were subdivided into four groups and were weekly exposed to five subcutaneous injections of 1,2-dimethylhydrazine (DMH) at a single dose of 21 mg/kg body weight.
Report a problemFND-1204980806
07AnimalAnimal study (in vivo)Efficacy outcome
In DMH-treated rats, Epitalon inhibited the development of tumors in the jejunum and ileum.
In plain wordsIn rats given a colon carcinogen, Epitalon reduced tumor development in the small intestine.
Peptide
Epitalon
Outcome
DecreaseTumors in jejunum and ileum
Study
ratn: not reported in source
DMH-induced colon carcinogenesis in LIO rats
Comparator
Saline (group 1)
Outcome group
Tumor growth · Cancer
Studied dose
1 microg · subcutaneousAs given in this study (rat).
Source sentences
Summary
Epitalon inhibited also the development of tumors in jejunum and ileum.
2 context sentences(design, population, supporting numbers)
Summary · context
The effect of synthetic pineal peptide Epitalon (Ala-Glu-Asp-Gly) on colon carcinogenesis was firstly studied in rats.
Summary · context
Eighty 2-month-old outbred male LIO rats were subdivided into four groups and were weekly exposed to five subcutaneous injections of 1,2-dimethylhydrazine (DMH) at a single dose of 21 mg/kg body weight.
Report a problemFND-1204980807

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
9 Oct 2026, 18:17 UTC
Study results updated
Version 1
9 Oct 2026, 02:47 UTC
First added · source update from Europe PMC

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