In cells expressing the receptors, MTII bound the rat MC4 receptor with higher affinity than the human MC4 receptor (a 5- to 34-fold range was reported for the listed peptides together).
In plain wordsIn cells, MTII bound the rat MC4 receptor more tightly than the human MC4 receptor.
- Peptide
- Melanotan II
- Outcome
- Not applicableBinding affinity for rat versus human MC4 receptor
- Study
rat and humann: not reported in source
Rat and human MC3 and MC4 receptors expressed in a mammalian cell line- Outcome group
- Receptor activity and mechanism · Pharmacology
- Studied dose
- Dose not stated
Source sentences
NDP-, alpha-, beta-, gamma-MSH, ACTH(1-24), HS014 and MTII had from 5- to 34-fold higher affinity for the rat MC4 receptor, while SHU9119, HS024 and HS028 had similar affinity for both the MC4 receptors.
1 context sentence(design, population, supporting numbers)
We transiently expressed the genes for these receptors individually in a mammalian cell line and determined the binding affinities to several MSH peptides.