[Preclinical study of noopept toxicity].

Kovalenko LP, Smol'nikova NM, Alekseeva SV, Nemova EP, Sorokina AV, Miramedova MG, Kurapova SP, Sidorina EI, Kulakova AV, Daugel'-Dauge NO

Eksperimental'naia i klinicheskaia farmakologiia1 Jan 2002

PMID12025790PepBankPUB-12025790

Publisher pageAsk about this study

Jump to 10 results

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study10

10 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Safety outcome
In male and female rabbits, chronic noopept caused no irreversible pathological changes in the organs and systems studied.
In plain wordsIn rabbits, chronic noopept caused no irreversible damage in the organs and systems studied.
Peptide
Noopept (omberacetam)
Outcome
No significant changeIrreversible pathological changes
Study
rabbitn: not reported in source
Outcome group
Adverse events · Whole body
Studied dose
10 or 100 mg/kg · oral · 6 monthsAs given in this study (rabbit).
Source sentences
Summary
The results of observations showed that noopept administered in this dose range induced no irreversible pathologic changes in the organs and systems studied and exhibited no allergenic, immunotoxic, and mutagen activity.
1 context sentence(design, population, supporting numbers)
Summary · context
Within the framework of a preclinical investigation, the new nootrope drug noopept (N-phenyl-acetyl-L-propyl-glycine ethylate) was tested for chronic toxicity upon peroral administration in a dose of 10 or 100 mg/kg over 6 months in both male and female rabbits.
Report a problemFND-1202579001
02AnimalAnimal study (in vivo)Safety outcome
In rabbits, chronic noopept exhibited no allergenic activity.
In plain wordsIn rabbits, chronic noopept showed no allergenic activity.
Peptide
Noopept (omberacetam)
Outcome
No significant changeAllergenic activity
Study
rabbitn: not reported in source
Outcome group
Adverse events · Whole body
Studied dose
10 or 100 mg/kg · oral · 6 monthsAs given in this study (rabbit).
Source sentences
Summary
The results of observations showed that noopept administered in this dose range induced no irreversible pathologic changes in the organs and systems studied and exhibited no allergenic, immunotoxic, and mutagen activity.
1 context sentence(design, population, supporting numbers)
Summary · context
Within the framework of a preclinical investigation, the new nootrope drug noopept (N-phenyl-acetyl-L-propyl-glycine ethylate) was tested for chronic toxicity upon peroral administration in a dose of 10 or 100 mg/kg over 6 months in both male and female rabbits.
Report a problemFND-1202579002
03AnimalAnimal study (in vivo)Safety outcome
In rabbits, chronic noopept exhibited no immunotoxic activity.
In plain wordsIn rabbits, chronic noopept showed no immune toxicity.
Peptide
Noopept (omberacetam)
Outcome
No significant changeImmunotoxic activity
Study
rabbitn: not reported in source
Outcome group
Adverse events · Whole body
Studied dose
10 or 100 mg/kg · oral · 6 monthsAs given in this study (rabbit).
Source sentences
Summary
The results of observations showed that noopept administered in this dose range induced no irreversible pathologic changes in the organs and systems studied and exhibited no allergenic, immunotoxic, and mutagen activity.
1 context sentence(design, population, supporting numbers)
Summary · context
Within the framework of a preclinical investigation, the new nootrope drug noopept (N-phenyl-acetyl-L-propyl-glycine ethylate) was tested for chronic toxicity upon peroral administration in a dose of 10 or 100 mg/kg over 6 months in both male and female rabbits.
Report a problemFND-1202579003
04AnimalAnimal study (in vivo)Safety outcome
In rabbits, chronic noopept exhibited no mutagenic activity.
In plain wordsIn rabbits, chronic noopept showed no mutagenic activity.
Peptide
Noopept (omberacetam)
Outcome
No significant changeMutagenic activity
Study
rabbitn: not reported in source
Outcome group
Adverse events · Whole body
Studied dose
10 or 100 mg/kg · oral · 6 monthsAs given in this study (rabbit).
Source sentences
Summary
The results of observations showed that noopept administered in this dose range induced no irreversible pathologic changes in the organs and systems studied and exhibited no allergenic, immunotoxic, and mutagen activity.
1 context sentence(design, population, supporting numbers)
Summary · context
Within the framework of a preclinical investigation, the new nootrope drug noopept (N-phenyl-acetyl-L-propyl-glycine ethylate) was tested for chronic toxicity upon peroral administration in a dose of 10 or 100 mg/kg over 6 months in both male and female rabbits.
Report a problemFND-1202579004
05AnimalAnimal study (in vivo)Safety outcome
In the preclinical study, noopept did not affect generative function.
In plain wordsIn animals, noopept did not affect reproductive function.
Peptide
Noopept (omberacetam)
Outcome
No significant changeGenerative function
Study
n: not reported in source
Outcome group
Adverse events · Reproductive and sexual health
Studied dose
Dose not stated
Source sentences
Summary
The drug affected neither the generative function nor the antenatal or postnatal progeny development.
Report a problemFND-1202579005
06AnimalAnimal study (in vivo)Safety outcome
In the preclinical study, noopept did not affect antenatal progeny development.
In plain wordsIn animals, noopept did not affect offspring development before birth.
Peptide
Noopept (omberacetam)
Outcome
No significant changeAntenatal progeny development
Study
n: not reported in source
Outcome group
Adverse events · Reproductive and sexual health
Studied dose
Dose not stated
Source sentences
Summary
The drug affected neither the generative function nor the antenatal or postnatal progeny development.
Report a problemFND-1202579006
07AnimalAnimal study (in vivo)Safety outcome
In the preclinical study, noopept did not affect postnatal progeny development.
In plain wordsIn animals, noopept did not affect offspring development after birth.
Peptide
Noopept (omberacetam)
Outcome
No significant changePostnatal progeny development
Study
n: not reported in source
Outcome group
Adverse events · Reproductive and sexual health
Studied dose
Dose not stated
Source sentences
Summary
The drug affected neither the generative function nor the antenatal or postnatal progeny development.
Report a problemFND-1202579007
08AnimalAnimal study (in vivo)Efficacy outcome
In mice, noopept dose-dependently suppressed the inflammatory reaction to concanavalin A.
In plain wordsIn mice, noopept suppressed inflammation from concanavalin A in a dose-dependent manner.
Peptide
Noopept (omberacetam)
Outcome
DecreaseConcanavalin A inflammation
Study
mousen: not reported in source
Outcome group
Inflammation markers · Immune and inflammation
Studied dose
Dose not stated
Source sentences
Summary
Noopept produced a dose-dependent suppression of inflammation reaction to concanavalin A and stimulated the cellular and humoral immune response in mice.
Report a problemFND-1202579008
09AnimalAnimal study (in vivo)Mechanism
In mice, noopept stimulated the cellular immune response.
In plain wordsIn mice, noopept increased the cellular immune response.
Peptide
Noopept (omberacetam)
Outcome
IncreaseCellular immune response
Study
mousen: not reported in source
Outcome group
Immune response · Immune and inflammation
Studied dose
Dose not stated
Source sentences
Summary
Noopept produced a dose-dependent suppression of inflammation reaction to concanavalin A and stimulated the cellular and humoral immune response in mice.
Report a problemFND-1202579009
10AnimalAnimal study (in vivo)Mechanism
In mice, noopept stimulated the humoral immune response.
In plain wordsIn mice, noopept increased the humoral immune response.
Peptide
Noopept (omberacetam)
Outcome
IncreaseHumoral immune response
Study
mousen: not reported in source
Outcome group
Immune response · Immune and inflammation
Studied dose
Dose not stated
Source sentences
Summary
Noopept produced a dose-dependent suppression of inflammation reaction to concanavalin A and stimulated the cellular and humoral immune response in mice.
Report a problemFND-1202579010

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
21 Oct 2026, 15:58 UTC
Study results updated
Version 1
21 Oct 2026, 12:50 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

Journal Article

MeSH terms

PepBank is a research reference. Talk to a doctor before you use any peptide.