The leptin-like effects of 3-d peripheral administration of a melanocortin agonist are more marked in genetically obese Zucker (fa/fa) than in lean rats.

Cettour-Rose P, Rohner-Jeanrenaud F

Endocrinology1 Jun 2002Cited by 43 (Europe PMC)

PMID12021192DOI10.1210/endo.143.6.8871PepBankPUB-12021192

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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study8

8 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Efficacy outcome
In lean and obese fa/fa rats, 3-day MTII treatment lowered food intake, more so in obese than in lean rats.
In plain wordsIn rats, MTII lowered food intake, with a larger effect in obese rats than in lean rats.
Peptide
Melanotan II
Outcome
DecreaseFood intake
Study
ratn: not reported in source
Lean and genetically obese Zucker fa/fa rats
Comparator
Ad libitum fed and pair-fed controls
Outcome group
Appetite and food intake · Metabolic and weight
Studied dose
Dose not stated · peripheral · 3 daysAs given in this study (rat).
Source sentences
Summary
MTII treatment of lean and obese rats lowered food intake and body weight, the effects being more marked in obese than in lean rats.
1 context sentence(design, population, supporting numbers)
Summary · context
The effects of a 3-d peripheral administration of an alpha-MSH agonist, MTII, on body weight and the expression of uncoupling proteins (UCPs) and carnitine palmitoyltransferase-1 were determined in lean and genetically obese fa/fa rats
Report a problemFND-1202119201
02AnimalAnimal study (in vivo)Efficacy outcome
In lean and obese fa/fa rats, 3-day MTII treatment lowered body weight, more so in obese than in lean rats.
In plain wordsIn rats, MTII lowered body weight, with a larger effect in obese rats than in lean rats.
Peptide
Melanotan II
Outcome
DecreaseBody weight
Study
ratn: not reported in source
Lean and genetically obese Zucker fa/fa rats
Comparator
Ad libitum fed and pair-fed controls
Outcome group
Body weight · Metabolic and weight
Studied dose
Dose not stated · peripheral · 3 daysAs given in this study (rat).
Source sentences
Summary
MTII treatment of lean and obese rats lowered food intake and body weight, the effects being more marked in obese than in lean rats.
1 context sentence(design, population, supporting numbers)
Summary · context
The effects of a 3-d peripheral administration of an alpha-MSH agonist, MTII, on body weight and the expression of uncoupling proteins (UCPs) and carnitine palmitoyltransferase-1 were determined in lean and genetically obese fa/fa rats
Report a problemFND-1202119202
03AnimalAnimal study (in vivo)Efficacy outcome
In lean and obese rats, MTII suppressed the rise in plasma free fatty acids that food restriction caused.
In plain wordsIn rats, MTII lowered the rise in blood fatty acids that food restriction caused.
Peptide
Melanotan II
Outcome
DecreasePlasma free fatty acids
Study
ratn: not reported in source
Lean and genetically obese Zucker fa/fa rats
Comparator
Ad libitum fed and pair-fed controls
Outcome group
Lipids · Metabolic and weight
Studied dose
Dose not stated · peripheral · 3 daysAs given in this study (rat).
Source sentences
Summary
In both groups, MTII administration suppressed the increased plasma FFA levels brought about by food restriction.
1 context sentence(design, population, supporting numbers)
Summary · context
The effects of a 3-d peripheral administration of an alpha-MSH agonist, MTII, on body weight and the expression of uncoupling proteins (UCPs) and carnitine palmitoyltransferase-1 were determined in lean and genetically obese fa/fa rats
Report a problemFND-1202119203
04AnimalAnimal study (in vivo)Mechanism
In lean rats, MTII prevented the fall in brown adipose tissue UCP1, UCP2 and UCP3 expression that occurred with food restriction.
In plain wordsIn lean rats, MTII prevented the drop in brown fat uncoupling protein levels caused by food restriction.
Peptide
Melanotan II
Outcome
IncreaseBrown adipose tissue UCP1, UCP2 and UCP3 expression in lean rats
Study
ratn: not reported in source
Lean and genetically obese Zucker fa/fa rats
Comparator
Ad libitum fed and pair-fed controls
Outcome group
Mitochondrial function · Metabolic and weight
Studied dose
Dose not stated · peripheral · 3 daysAs given in this study (rat).
Source sentences
Summary
In lean rats, MTII prevented the decrease in brown adipose tissue UCP1, UCP2, and UCP3 expression and muscle UCP3 occurring during food restriction.
1 context sentence(design, population, supporting numbers)
Summary · context
The effects of a 3-d peripheral administration of an alpha-MSH agonist, MTII, on body weight and the expression of uncoupling proteins (UCPs) and carnitine palmitoyltransferase-1 were determined in lean and genetically obese fa/fa rats
Report a problemFND-1202119204
05AnimalAnimal study (in vivo)Mechanism
In lean rats, MTII prevented the fall in muscle UCP3 expression that occurred with food restriction.
In plain wordsIn lean rats, MTII prevented the drop in muscle UCP3 caused by food restriction.
Peptide
Melanotan II
Outcome
IncreaseMuscle UCP3 expression in lean rats
Study
ratn: not reported in source
Lean and genetically obese Zucker fa/fa rats
Comparator
Ad libitum fed and pair-fed controls
Outcome group
Mitochondrial function · Metabolic and weight
Studied dose
Dose not stated · peripheral · 3 daysAs given in this study (rat).
Source sentences
Summary
In lean rats, MTII prevented the decrease in brown adipose tissue UCP1, UCP2, and UCP3 expression and muscle UCP3 occurring during food restriction.
1 context sentence(design, population, supporting numbers)
Summary · context
The effects of a 3-d peripheral administration of an alpha-MSH agonist, MTII, on body weight and the expression of uncoupling proteins (UCPs) and carnitine palmitoyltransferase-1 were determined in lean and genetically obese fa/fa rats
Report a problemFND-1202119205
06AnimalAnimal study (in vivo)Mechanism
In obese fa/fa rats, MTII increased brown adipose tissue UCP3 expression 7-fold.
In plain wordsIn obese rats, MTII raised brown fat UCP3 levels about 7-fold.
Peptide
Melanotan II
Outcome
IncreaseBrown adipose tissue UCP3 expression in obese rats
Study
ratn: not reported in source
Lean and genetically obese Zucker fa/fa rats
Comparator
Ad libitum fed and pair-fed controls
Outcome group
Mitochondrial function · Metabolic and weight
Studied dose
Dose not stated · peripheral · 3 daysAs given in this study (rat).
Measurements
BAT UCP3 expression fold increase
7 fold
obese fa/fa rats
Source sentences
Summary
In obese animals, MTII markedly increased brown adipose tissue (7-fold)
1 context sentence(design, population, supporting numbers)
Summary · context
The effects of a 3-d peripheral administration of an alpha-MSH agonist, MTII, on body weight and the expression of uncoupling proteins (UCPs) and carnitine palmitoyltransferase-1 were determined in lean and genetically obese fa/fa rats
Report a problemFND-1202119206
07AnimalAnimal study (in vivo)Mechanism
In obese fa/fa rats, MTII increased muscle UCP3 expression 2.5-fold.
In plain wordsIn obese rats, MTII raised muscle UCP3 levels about 2.5-fold.
Peptide
Melanotan II
Outcome
IncreaseMuscle UCP3 expression in obese rats
Study
ratn: not reported in source
Lean and genetically obese Zucker fa/fa rats
Comparator
Ad libitum fed and pair-fed controls
Outcome group
Mitochondrial function · Metabolic and weight
Studied dose
Dose not stated · peripheral · 3 daysAs given in this study (rat).
Measurements
Muscle UCP3 expression fold increase
2.5 fold
obese fa/fa rats
Source sentences
Summary
and muscle (2.5-fold) UCP3 expression.
1 context sentence(design, population, supporting numbers)
Summary · context
The effects of a 3-d peripheral administration of an alpha-MSH agonist, MTII, on body weight and the expression of uncoupling proteins (UCPs) and carnitine palmitoyltransferase-1 were determined in lean and genetically obese fa/fa rats
Report a problemFND-1202119207
08AnimalAnimal study (in vivo)Mechanism
In lean and obese rats, MTII prevented the fall in liver carnitine palmitoyltransferase-1 that food restriction caused.
In plain wordsIn rats, MTII prevented the drop in a liver fat-burning enzyme caused by food restriction.
Peptide
Melanotan II
Outcome
IncreaseLiver carnitine palmitoyltransferase-1
Study
ratn: not reported in source
Lean and genetically obese Zucker fa/fa rats
Comparator
Ad libitum fed and pair-fed controls
Outcome group
Mitochondrial function · Liver
Studied dose
Dose not stated · peripheral · 3 daysAs given in this study (rat).
Source sentences
Summary
The decrease in liver carnitine palmitoyltransferase-1 elicited by food restriction in lean and obese rats was prevented by MTII administration.
1 context sentence(design, population, supporting numbers)
Summary · context
The effects of a 3-d peripheral administration of an alpha-MSH agonist, MTII, on body weight and the expression of uncoupling proteins (UCPs) and carnitine palmitoyltransferase-1 were determined in lean and genetically obese fa/fa rats
Report a problemFND-1202119208

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
10 Oct 2026, 09:43 UTC
Study results updated
Version 1
9 Oct 2026, 03:04 UTC
First added · source update from Europe PMC

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The leptin-like effects of 3-d peripheral administration of a melanocortin agonist are more marked in genetically obese Zucker (fa/fa) than in lean rats.

Summary

Results from this study8

Version history

Subjects

Publication types

MeSH terms