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Study · Animal study (in vivo) · mouse · 2002

10 results

Effects of acute and chronic administration of the melanocortin agonist MTII in mice with diet-induced obesity.

Pierroz DD, Ziotopoulou M, Ungsunan L, Moschos S, Flier JS, Mantzoros CS

Diabetes1 May 2002Cited by 161 (Europe PMC)

PMID11978628 (opens in a new tab)DOI10.2337/diabetes.51.5.1337 (opens in a new tab)PepBankPUB-11978628
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study10

10 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In mice with diet-induced obesity, intraperitoneal MTII markedly suppressed feeding during the first 4 days of treatment.

    In plain wordsIn obese mice, MTII injections strongly reduced eating in the first 4 days.

    Peptide
    Melanotan II
    Outcome
    DecreaseFood intake during first 4 days of treatment
    Study

    mousen: not reported in source

    diet-induced obesity (DIO) C57BL/6J mice
    Comparator
    Control
    Outcome group
    Appetite and food intake · Metabolic and weight
    Studied dose
    100 microg q.i.d. · intraperitoneal · 4 daysAs given in this study (mouse).

    Source sentences

    Summary
    In DIO mice, administration of MTII 100 microg q.i.d. i.p. markedly suppressed feeding during the first 4 days of treatment, with food intake returning to control levels at day 5.
    1 context sentence
    Summary · context
    We assessed the response of mice with DIO to treatment with MTII, an alpha-melanocyte-stimulating hormone analog.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In mice with diet-induced obesity, food intake returned to control levels at day 5 of intraperitoneal MTII treatment.

    In plain wordsIn obese mice, eating returned to control levels by day 5 of MTII treatment.

    Peptide
    Melanotan II
    Outcome
    No significant changeFood intake at day 5 of treatment
    Study

    mousen: not reported in source

    diet-induced obesity (DIO) C57BL/6J mice
    Comparator
    Control
    Outcome group
    Appetite and food intake · Metabolic and weight
    Studied dose
    100 microg q.i.d. · intraperitoneal · 5 daysAs given in this study (mouse).

    Source sentences

    Summary
    with food intake returning to control levels at day 5.
    1 context sentence
    Summary · context
    We assessed the response of mice with DIO to treatment with MTII, an alpha-melanocyte-stimulating hormone analog.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In mice with diet-induced obesity, intraperitoneal MTII caused progressive weight loss over the first 4 days, after which weight plateaued below control.

    In plain wordsIn obese mice, MTII injections caused weight loss over 4 days, then weight stayed below that of control mice.

    Peptide
    Melanotan II
    Outcome
    DecreaseBody weight during MTII treatment
    Study

    mousen: not reported in source

    diet-induced obesity (DIO) C57BL/6J mice
    Comparator
    Control
    Outcome group
    Body weight · Metabolic and weight
    Studied dose
    100 microg q.i.d. · intraperitoneal · 4 daysAs given in this study (mouse).

    Source sentences

    Summary
    Progressive weight loss also occurred over the first 4 days, after which weight plateaued at a level below control.
    1 context sentence
    Summary · context
    We assessed the response of mice with DIO to treatment with MTII, an alpha-melanocyte-stimulating hormone analog.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In mice with diet-induced obesity, 8 days of MTII treatment gave major suppression of leptin levels.

    In plain wordsIn obese mice, 8 days of MTII injections greatly lowered leptin levels.

    Peptide
    Melanotan II
    Outcome
    DecreaseLeptin level after 8 days
    Study

    mousen: not reported in source

    diet-induced obesity (DIO) C57BL/6J mice
    Comparator
    Control
    Outcome group
    Hormone levels · Endocrine and hormones
    Studied dose
    100 microg q.i.d. · intraperitoneal · 8 daysAs given in this study (mouse).

    Source sentences

    Summary
    After 8 days of treatment, MTII-treated DIO mice had major suppression of both leptin and insulin levels.
    1 context sentence
    Summary · context
    We assessed the response of mice with DIO to treatment with MTII, an alpha-melanocyte-stimulating hormone analog.
  5. 05AnimalAnimal study (in vivo)Efficacy outcome

    In mice with diet-induced obesity, 8 days of MTII treatment gave major suppression of insulin levels.

    In plain wordsIn obese mice, 8 days of MTII injections greatly lowered insulin levels.

    Peptide
    Melanotan II
    Outcome
    DecreaseInsulin level after 8 days
    Study

    mousen: not reported in source

    diet-induced obesity (DIO) C57BL/6J mice
    Comparator
    Control
    Outcome group
    Glycemic control · Metabolic and weight
    Studied dose
    100 microg q.i.d. · intraperitoneal · 8 daysAs given in this study (mouse).

    Source sentences

    Summary
    After 8 days of treatment, MTII-treated DIO mice had major suppression of both leptin and insulin levels.
    1 context sentence
    Summary · context
    We assessed the response of mice with DIO to treatment with MTII, an alpha-melanocyte-stimulating hormone analog.
  6. 06AnimalAnimal study (in vivo)Efficacy outcome

    In mice with diet-induced obesity, central MTII for 4 days significantly suppressed food intake.

    In plain wordsIn obese mice, MTII given into the brain for 4 days reduced eating.

    Peptide
    Melanotan II
    Outcome
    DecreaseFood intake with central MTII
    Study

    mousen: not reported in source

    diet-induced obesity (DIO) C57BL/6J mice
    Comparator
    Control
    Outcome group
    Appetite and food intake · Metabolic and weight
    Studied dose
    10 nmol/day · central · 4 daysAs given in this study (mouse).

    Source sentences

    Summary
    Central administration of MTII for 4 days (10 nmol/day) in DIO mice significantly suppressed food intake, induced weight loss, and increased energy expenditure.
    1 context sentence
    Summary · context
    We assessed the response of mice with DIO to treatment with MTII, an alpha-melanocyte-stimulating hormone analog.
  7. 07AnimalAnimal study (in vivo)Efficacy outcome

    In mice with diet-induced obesity, central MTII for 4 days significantly induced weight loss.

    In plain wordsIn obese mice, MTII given into the brain for 4 days caused weight loss.

    Peptide
    Melanotan II
    Outcome
    DecreaseBody weight with central MTII
    Study

    mousen: not reported in source

    diet-induced obesity (DIO) C57BL/6J mice
    Comparator
    Control
    Outcome group
    Body weight · Metabolic and weight
    Studied dose
    10 nmol/day · central · 4 daysAs given in this study (mouse).

    Source sentences

    Summary
    Central administration of MTII for 4 days (10 nmol/day) in DIO mice significantly suppressed food intake, induced weight loss, and increased energy expenditure.
    1 context sentence
    Summary · context
    We assessed the response of mice with DIO to treatment with MTII, an alpha-melanocyte-stimulating hormone analog.
  8. 08AnimalAnimal study (in vivo)Efficacy outcome

    In mice with diet-induced obesity, central MTII for 4 days significantly increased energy expenditure.

    In plain wordsIn obese mice, MTII given into the brain for 4 days raised energy use.

    Peptide
    Melanotan II
    Outcome
    IncreaseEnergy expenditure with central MTII
    Study

    mousen: not reported in source

    diet-induced obesity (DIO) C57BL/6J mice
    Comparator
    Control
    Outcome group
    Body weight · Metabolic and weight
    Studied dose
    10 nmol/day · central · 4 daysAs given in this study (mouse).

    Source sentences

    Summary
    Central administration of MTII for 4 days (10 nmol/day) in DIO mice significantly suppressed food intake, induced weight loss, and increased energy expenditure.
    1 context sentence
    Summary · context
    We assessed the response of mice with DIO to treatment with MTII, an alpha-melanocyte-stimulating hormone analog.
  9. 09AnimalAnimal study (in vivo)Efficacy outcome

    In C57BL/6J mice, MTII given four times daily by intraperitoneal injection produced a dose-responsive effect on corticosterone.

    In plain wordsIn mice, MTII injections changed corticosterone levels depending on the dose.

    Peptide
    Melanotan II
    Outcome
    Direction not reportedCorticosterone, dose-responsive effect
    Study

    mousen: not reported in source

    C57BL/6J mice
    Comparator
    Control
    Outcome group
    Hormone levels · Endocrine and hormones
    Studied dose
    Dose not stated · intraperitonealAs given in this study (mouse).

    Source sentences

    Summary
    MTII delivered four times daily by intraperitoneal injection to C57BL/6J mice produced a dose-responsive effect on food intake, body weight, leptin, corticosterone, insulin, and free fatty acids.
    1 context sentence
    Summary · context
    We assessed the response of mice with DIO to treatment with MTII, an alpha-melanocyte-stimulating hormone analog.
  10. 10AnimalAnimal study (in vivo)Efficacy outcome

    In C57BL/6J mice, MTII given four times daily by intraperitoneal injection produced a dose-responsive effect on free fatty acids.

    In plain wordsIn mice, MTII injections changed free fatty acid levels depending on the dose.

    Peptide
    Melanotan II
    Outcome
    Direction not reportedFree fatty acids, dose-responsive effect
    Study

    mousen: not reported in source

    C57BL/6J mice
    Comparator
    Control
    Outcome group
    Hormone levels · Metabolic and weight
    Studied dose
    Dose not stated · intraperitonealAs given in this study (mouse).

    Source sentences

    Summary
    MTII delivered four times daily by intraperitoneal injection to C57BL/6J mice produced a dose-responsive effect on food intake, body weight, leptin, corticosterone, insulin, and free fatty acids.
    1 context sentence
    Summary · context
    We assessed the response of mice with DIO to treatment with MTII, an alpha-melanocyte-stimulating hormone analog.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    9 Oct 2026, 18:17 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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