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Study · Animal study (in vivo) · rat · 2002

5 results

The melanocortin receptor agonist MTII augments the rewarding effect of amphetamine in ad-libitum-fed and food-restricted rats.

Cabeza de Vaca S, Kim GY, Carr KD

Psychopharmacology6 Mar 2002Cited by 41 (Europe PMC)

PMID11967634 (opens in a new tab)DOI10.1007/s00213-002-0998-1 (opens in a new tab)PepBankPUB-11967634
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

5 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In ad-libitum-fed rats, intracerebroventricular MTII suppressed overnight food intake.

    In plain wordsIn rats, MTII given into the brain reduced overnight food intake.

    Peptide
    Melanotan II
    Outcome
    DecreaseOvernight food intake in ad-libitum-fed rats
    Study

    ratn: not reported in source

    Comparator
    Vehicle
    Outcome group
    Appetite and food intake · Metabolic and weight
    Studied dose
    1.0 microg · intracerebroventricular (lateral ventricle)As given in this study (rat).

    Source sentences

    Summary
    MTII, the alpha-MSH-like agonist, suppressed overnight food intake of ad-libitum-fed rats following i.c.v. injection of 1.0 microg.
    1 context sentence
    Summary · context
    The modulatory effects of MTII and SHU9119 were evaluated by preceding i.c.v. amphetamine injection with i.c.v. injection of one of these MCR ligands or vehicle.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In rats, MTII had no effect on thresholds for lateral hypothalamic self-stimulation 60 min after injection.

    In plain wordsIn rats, MTII alone did not change the brain reward threshold 60 minutes after injection.

    Peptide
    Melanotan II
    Outcome
    No significant changeLateral hypothalamic self-stimulation threshold, MTII alone at 60 min
    Study

    ratn: not reported in source

    Comparator
    Vehicle
    Outcome group
    Addiction, withdrawal and alcohol intake · Nervous system and cognition
    Studied dose
    Dose not stated · intracerebroventricular (lateral ventricle)As given in this study (rat).

    Source sentences

    Summary
    MTII had no effect on thresholds for LHSS tested 60 min post-injection.
    1 context sentence
    Summary · context
    The modulatory effects of MTII and SHU9119 were evaluated by preceding i.c.v. amphetamine injection with i.c.v. injection of one of these MCR ligands or vehicle.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In ad-libitum-fed rats, MTII potentiated the threshold-lowering (rewarding) effect of amphetamine tested 100 min after injection.

    In plain wordsIn rats, MTII increased the rewarding effect of amphetamine 100 minutes after injection.

    Peptide
    Melanotan II
    Outcome
    IncreaseAmphetamine reward at 100 min, ad-libitum-fed rats
    Study

    ratn: not reported in source

    Comparator
    Vehicle
    Outcome group
    Addiction, withdrawal and alcohol intake · Nervous system and cognition
    Studied dose
    Dose not stated · intracerebroventricular (lateral ventricle)As given in this study (rat).

    Source sentences

    Summary
    However, this MCR agonist potentiated the threshold-lowering effect of amphetamine tested 100 min but not 24 h post-injection. This effect was evident in both ad-libitum-fed and food-restricted rats.
    1 context sentence
    Summary · context
    The modulatory effects of MTII and SHU9119 were evaluated by preceding i.c.v. amphetamine injection with i.c.v. injection of one of these MCR ligands or vehicle.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In food-restricted rats, MTII potentiated the threshold-lowering (rewarding) effect of amphetamine tested 100 min after injection.

    In plain wordsIn food-restricted rats, MTII increased the rewarding effect of amphetamine 100 minutes after injection.

    Peptide
    Melanotan II
    Outcome
    IncreaseAmphetamine reward at 100 min, food-restricted rats
    Study

    ratn: not reported in source

    Comparator
    Vehicle
    Outcome group
    Addiction, withdrawal and alcohol intake · Nervous system and cognition
    Studied dose
    Dose not stated · intracerebroventricular (lateral ventricle)As given in this study (rat).

    Source sentences

    Summary
    However, this MCR agonist potentiated the threshold-lowering effect of amphetamine tested 100 min but not 24 h post-injection. This effect was evident in both ad-libitum-fed and food-restricted rats.
    1 context sentence
    Summary · context
    The modulatory effects of MTII and SHU9119 were evaluated by preceding i.c.v. amphetamine injection with i.c.v. injection of one of these MCR ligands or vehicle.
  5. 05AnimalAnimal study (in vivo)Efficacy outcome

    In rats, MTII did not potentiate the threshold-lowering effect of amphetamine tested 24 h after injection.

    In plain wordsIn rats, MTII did not increase the rewarding effect of amphetamine 24 hours after injection.

    Peptide
    Melanotan II
    Outcome
    No significant changeAmphetamine reward at 24 h
    Study

    ratn: not reported in source

    Comparator
    Vehicle
    Outcome group
    Addiction, withdrawal and alcohol intake · Nervous system and cognition
    Studied dose
    Dose not stated · intracerebroventricular (lateral ventricle)As given in this study (rat).

    Source sentences

    Summary
    However, this MCR agonist potentiated the threshold-lowering effect of amphetamine tested 100 min but not 24 h post-injection.
    1 context sentence
    Summary · context
    The modulatory effects of MTII and SHU9119 were evaluated by preceding i.c.v. amphetamine injection with i.c.v. injection of one of these MCR ligands or vehicle.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    9 Oct 2026, 18:17 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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