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Study · Animal study (in vivo) · rat · 2002

4 results

Behavioral processes underlying the intake suppressive effects of melanocortin 3/4 receptor activation in the rat.

Williams DL, Grill HJ, Weiss SM, Baird JP, Kaplan JM

Psychopharmacology1 Mar 2002Cited by 41 (Europe PMC)

PMID11967630 (opens in a new tab)DOI10.1007/s00213-002-1022-5 (opens in a new tab)PepBankPUB-11967630
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In rats drinking glucose solution, ICV MTII reduced meal size by 20-50% in a dose-dependent manner in both experiments.

    In plain wordsIn rats, MTII reduced meal size in a dose-dependent way.

    Peptide
    Melanotan II
    Outcome
    DecreaseMeal size
    Study

    ratn: not reported in source

    Rats drinking 12.5% glucose solution
    Comparator
    Vehicle
    Outcome group
    Appetite and food intake · Metabolic and weight
    Studied dose
    0.1, 0.33 and 1.0 nmol · ICVAs given in this study (rat).

    Measurements

    Meal size reduction
    20 to 50%
    dose-dependent, both experiments

    Source sentences

    Summary
    Meal size was reduced by MTII in a dose-dependent manner (20-50%) in both experiments.
    1 context sentence
    Summary · context
    We compared rats' glucose intake 30 min after the fourth ICV injection of 0.1, 0.33, and 1.0 nmol MTII or vehicle.
  2. 02AnimalAnimal study (in vivo)Mechanism

    In rats, MTII-treated animals compensated for a smaller lick volume by substantially increasing the number of licks, as controls did.

    In plain wordsIn rats given MTII, the animals licked more when each lick delivered less, so motor performance was not disrupted.

    Peptide
    Melanotan II
    Outcome
    IncreaseLicks emitted after lick volume was reduced
    Study

    ratn: not reported in source

    Rats drinking 12.5% glucose solution
    Comparator
    Vehicle
    Outcome group
    Appetite and food intake · Metabolic and weight
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Rats treated with MTII compensated for decreased lick volume by substantially increasing the number of licks emitted.
    1 context sentence
    Summary · context
    A second experiment directly analyzed the effect of MTII on motor performance by examining whether drug treated rats would, like controls, adjust licking output to maintain meal size when lick volume was shifted from 8 to 4 microl.
  3. 03AnimalAnimal study (in vivo)Mechanism

    In rats drinking glucose solution, licking parameters linked to taste evaluation were not significantly affected by MTII.

    In plain wordsIn rats, MTII did not significantly change licking patterns linked to taste.

    Peptide
    Melanotan II
    Outcome
    No significant changeLicking parameters of taste evaluation
    Study

    ratn: not reported in source

    Rats drinking 12.5% glucose solution
    Comparator
    Vehicle
    Outcome group
    Appetite and food intake · Metabolic and weight
    Studied dose
    0.1, 0.33 and 1.0 nmol · ICVAs given in this study (rat).

    Source sentences

    Summary
    Licking parameters associated with taste evaluation were not significantly affected by MTII
    1 context sentence
    Summary · context
    We compared rats' glucose intake 30 min after the fourth ICV injection of 0.1, 0.33, and 1.0 nmol MTII or vehicle.
  4. 04AnimalAnimal study (in vivo)Mechanism

    In rats drinking glucose solution, licking parameters linked to post-ingestive inhibition varied as a function of MTII treatment; the abstract does not give the direction.

    In plain wordsIn rats, MTII changed licking patterns linked to feeling full after eating.

    Peptide
    Melanotan II
    Outcome
    Direction not reportedLicking parameters of post-ingestive inhibition
    Study

    ratn: not reported in source

    Rats drinking 12.5% glucose solution
    Comparator
    Vehicle
    Outcome group
    Appetite and food intake · Metabolic and weight
    Studied dose
    0.1, 0.33 and 1.0 nmol · ICVAs given in this study (rat).

    Source sentences

    Summary
    whereas parameters associated with post-ingestive inhibition varied as a function of treatment.
    1 context sentence
    Summary · context
    We compared rats' glucose intake 30 min after the fourth ICV injection of 0.1, 0.33, and 1.0 nmol MTII or vehicle.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    10 Oct 2026, 09:43 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

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