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Study · Not a test of the peptide alone · 2002

3 results

Is GHRH receptor essential to GHRP-2-induced GH secretion in primary cultured rat pituitary cells?

Roh SG, Chen C, Choi KC, Shrestha Y, Sasaki S

Endocrinology1 May 2002Cited by 6 (Europe PMC)

PMID11956179 (opens in a new tab)DOI10.1210/endo.143.5.8893 (opens in a new tab)PepBankPUB-11956179
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone3

In this study, GHRP-2 was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking GHRP-2.

  1. 01LabNot a test of GHRP-2 aloneIn vitro (cells)Mechanism

    In cultured rat pituitary cells, antisense GHS-R oligonucleotide reduced, but did not abolish, GH secretion induced by GHRP‑2.

    In plain wordsIn rat pituitary cells, blocking the GHS-R gene lowered, but did not stop, the growth hormone release caused by GHRP‑2.

    Peptide
    GHRP-2
    Outcome
    DecreaseGHRP-2-induced GH secretion after antisense GHS-R treatment
    Study

    ratn: not reported in source

    Primary cultured rat pituitary cells
    Comparator
    Sense oligonucleotide control
    Outcome group
    Receptor activity and mechanism · Endocrine and hormones

    Source sentences

    Summary
    Treatment with antisense GHS-R ON reduced (but not abolished) GHRP-2-induced GH secretion although GHRH-induced GH secretion was not altered.
    1 context sentence
    Summary · context
    Rat pituitary cells were incubated for 3 days in the presence or absence of antisense 18-mer phosphorothiate oligonucleotides (ONs) complementary to the codon region of GHS-R or GHRH-R mRNAs.

    In this study, GHRP-2 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHRP-2.

  2. 02LabNot a test of GHRP-2 aloneIn vitro (cells)Mechanism

    In cultured rat pituitary cells, antisense GHRH-R oligonucleotide did not affect GH secretion induced by GHRP‑2.

    In plain wordsIn rat pituitary cells, blocking the GHRH-R gene did not change the growth hormone release caused by GHRP‑2.

    Peptide
    GHRP-2
    Outcome
    No significant changeGHRP-2-induced GH secretion after antisense GHRH-R treatment
    Study

    ratn: not reported in source

    Primary cultured rat pituitary cells
    Comparator
    Sense oligonucleotide control
    Outcome group
    Receptor activity and mechanism · Endocrine and hormones

    Source sentences

    Summary
    GHRH-stimulated GH secretion was totally abolished by the treatment with antisense GHRH-R ON, whereas GHRP-2 induced GH secretion was not affected.
    1 context sentence
    Summary · context
    Rat pituitary cells were incubated for 3 days in the presence or absence of antisense 18-mer phosphorothiate oligonucleotides (ONs) complementary to the codon region of GHS-R or GHRH-R mRNAs.

    In this study, GHRP-2 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHRP-2.

  3. 03LabNot a test of GHRP-2 aloneIn vitro (cells)Mechanism

    In cultured rat pituitary cells, combined antisense oligonucleotides to GHS-R and GHRH-R completely inhibited GH secretion stimulated by GHRP‑2.

    In plain wordsIn rat pituitary cells, blocking both the GHS-R and GHRH-R genes completely stopped growth hormone release caused by GHRP‑2.

    Peptide
    GHRP-2
    Outcome
    DecreaseGHRP-2-stimulated GH secretion after combined antisense GHS-R and GHRH-R treatment
    Study

    ratn: not reported in source

    Primary cultured rat pituitary cells
    Comparator
    Sense oligonucleotide control
    Outcome group
    Receptor activity and mechanism · Endocrine and hormones

    Source sentences

    Summary
    Treatment of cells with both GHS-R and GHRH-2 ONs however completely inhibited GHRH and GHRP-2-stimulated GH secretion.
    1 context sentence
    Summary · context
    Rat pituitary cells were incubated for 3 days in the presence or absence of antisense 18-mer phosphorothiate oligonucleotides (ONs) complementary to the codon region of GHS-R or GHRH-R mRNAs.

    In this study, GHRP-2 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHRP-2.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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