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Study · Animal study (in vivo) · rat · 2002

2 results

Responsivity to NPY and melanocortins in obese OLETF rats lacking CCK-A receptors.

Moran TH, Lee P, Ladenheim EE, Schwartz GJ

Physiology & behavior1 Mar 2002Cited by 10 (Europe PMC)

PMID11897267 (opens in a new tab)DOI10.1016/s0031-9384(01)00667-9 (opens in a new tab)PepBankPUB-11897267
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

2 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In OLETF rats lacking CCK-A receptors and in lean LETO control rats, lateral ventricular MTII infusion decreased food intake.

    In plain wordsIn rats, brain infusion of MTII reduced food intake, both in obese OLETF rats and in lean LETO rats.

    Peptide
    Melanotan II
    Outcome
    DecreaseFood intake after MTII infusion
    Study

    ratn: not reported in source

    OLETF and LETO rats
    Outcome group
    Appetite and food intake · Metabolic and weight
    Studied dose
    0.1 and 0.32 nmol · lateral ventricular infusionAs given in this study (rat).

    Source sentences

    Summary
    The melanocortin agonist MTII decreased intake in both LETO and OLETF rats.
    1 context sentence
    Summary · context
    we assessed OLETF and LETO rats feeding responses to lateral ventricular infusions of NPY (1 and 3.2 nmol), the melanocortin 3/4 agonist MTII (0.1 and 0.32 nmol)
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    At the 20-h time point, MTII suppressed food intake more in OLETF rats than in LETO rats.

    In plain wordsIn rats, MTII suppressed food intake more strongly in obese OLETF rats than in lean LETO rats after 20 hours.

    Peptide
    Melanotan II
    Outcome
    DecreaseSuppression of food intake by MTII at 20 h, OLETF versus LETO
    Study

    ratn: not reported in source

    OLETF and LETO rats
    Comparator
    LETO rats
    Outcome group
    Appetite and food intake · Metabolic and weight
    Studied dose
    0.1 and 0.32 nmol · lateral ventricular infusionAs given in this study (rat).

    Source sentences

    Summary
    At the 20-h time point, the magnitude of suppression was greater in OLETF rats.
    1 context sentence
    Summary · context
    we assessed OLETF and LETO rats feeding responses to lateral ventricular infusions of NPY (1 and 3.2 nmol), the melanocortin 3/4 agonist MTII (0.1 and 0.32 nmol)

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    10 Oct 2026, 09:43 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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