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Study · Animal study (in vivo) · rat · 2002

4 results

The effects of delta sleep-inducing peptide on incidence and severity in metaphit-induced epilepsy in rats.

Stanojlović OP, Zivanović DP, Susić VT

Pharmacological research1 Mar 2002Cited by 6 (Europe PMC)

PMID11884222 (opens in a new tab)DOI10.1006/phrs.2001.0938 (opens in a new tab)PepBankPUB-11884222
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In adult male Wistar rats given metaphit, DSIP at 1 mg/kg increased delta-wave power spectra (2-11 h) compared with the saline-control group.

    In plain wordsIn rats, DSIP at the most effective dose increased delta-wave brain activity compared with saline-treated rats.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    IncreaseDelta-wave power spectra
    Study

    ratn: not reported in source

    Comparator
    Saline-control group
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    1 mg/kgAs given in this study (rat).

    Source sentences

    Summary
    DSIP acted as an anticonvulsant and the most potent anticonvulsive dose of 1 mg x kg (-1)significantly increased power spectra of deltawaves (2-11 h) in comparison with the saline-control group and decreased the incidence and duration of convulsive response, as well as mean seizure grade of metaphit…
    2 context sentences
    Summary · context
    The effects of delta sleep-inducing peptide (DSIP) on metaphit- (1-(1(3-isothiocyanatophenyl)-cyclohexyl) (piperidine)-) induced audiogenic seizures in adult male Wistar rats were studied.
    Summary · context
    Upon treatment, the rats were exposed to sound stimulation ( 100 +/- 3 dB, 60 s) at hourly intervals and the incidence and severity (running, clonus and tonus) of seizures were analyzed.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In rats with metaphit-induced audiogenic seizures, DSIP at 1 mg/kg decreased the incidence of convulsive response.

    In plain wordsIn rats, DSIP at the most effective dose lowered how often seizures occurred after metaphit.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    DecreaseIncidence of metaphit-induced convulsions
    Study

    ratn: not reported in source

    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    1 mg/kgAs given in this study (rat).

    Source sentences

    Summary
    DSIP acted as an anticonvulsant and the most potent anticonvulsive dose of 1 mg x kg (-1)significantly increased power spectra of deltawaves (2-11 h) in comparison with the saline-control group and decreased the incidence and duration of convulsive response, as well as mean seizure grade of metaphit…
    2 context sentences
    Summary · context
    The effects of delta sleep-inducing peptide (DSIP) on metaphit- (1-(1(3-isothiocyanatophenyl)-cyclohexyl) (piperidine)-) induced audiogenic seizures in adult male Wistar rats were studied.
    Summary · context
    Upon treatment, the rats were exposed to sound stimulation ( 100 +/- 3 dB, 60 s) at hourly intervals and the incidence and severity (running, clonus and tonus) of seizures were analyzed.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In rats with metaphit-induced audiogenic seizures, DSIP at 1 mg/kg decreased the duration of the convulsive response.

    In plain wordsIn rats, DSIP at the most effective dose shortened seizures caused by metaphit.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    DecreaseDuration of metaphit-induced convulsive response
    Study

    ratn: not reported in source

    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    1 mg/kgAs given in this study (rat).

    Source sentences

    Summary
    DSIP acted as an anticonvulsant and the most potent anticonvulsive dose of 1 mg x kg (-1)significantly increased power spectra of deltawaves (2-11 h) in comparison with the saline-control group and decreased the incidence and duration of convulsive response, as well as mean seizure grade of metaphit…
    2 context sentences
    Summary · context
    The effects of delta sleep-inducing peptide (DSIP) on metaphit- (1-(1(3-isothiocyanatophenyl)-cyclohexyl) (piperidine)-) induced audiogenic seizures in adult male Wistar rats were studied.
    Summary · context
    Upon treatment, the rats were exposed to sound stimulation ( 100 +/- 3 dB, 60 s) at hourly intervals and the incidence and severity (running, clonus and tonus) of seizures were analyzed.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In rats with metaphit-induced audiogenic seizures, DSIP at 1 mg/kg decreased the mean seizure grade.

    In plain wordsIn rats, DSIP at the most effective dose lowered the severity of seizures caused by metaphit.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    DecreaseMean seizure grade of metaphit-induced convulsions
    Study

    ratn: not reported in source

    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    1 mg/kgAs given in this study (rat).

    Source sentences

    Summary
    DSIP acted as an anticonvulsant and the most potent anticonvulsive dose of 1 mg x kg (-1)significantly increased power spectra of deltawaves (2-11 h) in comparison with the saline-control group and decreased the incidence and duration of convulsive response, as well as mean seizure grade of metaphit…
    2 context sentences
    Summary · context
    The effects of delta sleep-inducing peptide (DSIP) on metaphit- (1-(1(3-isothiocyanatophenyl)-cyclohexyl) (piperidine)-) induced audiogenic seizures in adult male Wistar rats were studied.
    Summary · context
    Upon treatment, the rats were exposed to sound stimulation ( 100 +/- 3 dB, 60 s) at hourly intervals and the incidence and severity (running, clonus and tonus) of seizures were analyzed.

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    10 Oct 2026, 08:55 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

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