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Study · Not a test of the peptide alone · 2002

5 results

Steroidogenesis in bovine granulosa cells: the effect of short-term changes in dietary intake.

Armstrong DG, Gong JG, Gardner JO, Baxter G, Hogg CO, Webb R

Reproduction (Cambridge, England)1 Mar 2002Cited by 27 (Europe PMC)

PMID11882014 (opens in a new tab)DOI10.1530/rep.0.1230371 (opens in a new tab)PepBankPUB-11882014
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone5

In this study, IGF-1 LR3 was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking IGF-1 LR3.

  1. 01AnimalNot a test of IGF-1 LR3 aloneAnimal study (in vivo)Efficacy outcome

    In granulosa cells cultured from small follicles of heifers, the twice maintenance diet increased estradiol secretion after 4 days versus the maintenance diet.

    In plain wordsIn cow ovary cells, the higher-feed diet raised estradiol production in cells from small follicles after 4 days compared with the lower-feed diet.

    Peptide
    IGF-1 LR3
    Outcome
    IncreaseEstradiol secretion, small follicles, day 4
    Study

    cattlen: not reported in source

    Granulosa cells from heifers on two diets, cultured in vitro
    Comparator
    Maintenance diet
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health

    Source sentences

    Summary
    After 4 days in culture, granulosa cells isolated from small follicles, but not medium-sized follicles, collected from cattle offered the twice maintenance diet secreted significantly higher (P < 0.05) amounts of oestradiol compared with granulosa cells collected from cattle offered the maintenance diet.
    2 context sentences
    Summary · context
    Hereford x Friesian heifers (n = 24) were offered maintenance or twice maintenance diets during the experimental period (17 days).
    Summary · context
    Granulosa cells were isolated from small (1-4 mm) and medium-sized (4-8 mm) follicles and cultured in the presence of long R3-IGF-I or bFSH or both.

    In this study, IGF-1 LR3 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking IGF-1 LR3.

  2. 02AnimalNot a test of IGF-1 LR3 aloneAnimal study (in vivo)Efficacy outcome

    In granulosa cells cultured from medium-sized follicles of heifers, the twice maintenance diet did not increase estradiol secretion after 4 days.

    In plain wordsIn cow ovary cells, the higher-feed diet did not change estradiol production in cells from medium-sized follicles.

    Peptide
    IGF-1 LR3
    Outcome
    No significant changeEstradiol secretion, medium follicles, day 4
    Study

    cattlen: not reported in source

    Granulosa cells from heifers on two diets, cultured in vitro
    Comparator
    Maintenance diet
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health

    Source sentences

    Summary
    After 4 days in culture, granulosa cells isolated from small follicles, but not medium-sized follicles, collected from cattle offered the twice maintenance diet secreted significantly higher (P < 0.05) amounts of oestradiol compared with granulosa cells collected from cattle offered the maintenance diet.
    2 context sentences
    Summary · context
    Hereford x Friesian heifers (n = 24) were offered maintenance or twice maintenance diets during the experimental period (17 days).
    Summary · context
    Granulosa cells were isolated from small (1-4 mm) and medium-sized (4-8 mm) follicles and cultured in the presence of long R3-IGF-I or bFSH or both.

    In this study, IGF-1 LR3 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking IGF-1 LR3.

  3. 03AnimalNot a test of IGF-1 LR3 aloneAnimal study (in vivo)Efficacy outcome

    In granulosa cells from small follicles, the diet effect on estradiol appeared with or without FSH and long R3-IGF-I in culture.

    In plain wordsIn cow ovary cells, the diet effect on estradiol was the same whether or not FSH or long R3-IGF-I was added.

    Peptide
    IGF-1 LR3
    Outcome
    IncreaseDiet effect on estradiol with or without FSH and long R3-IGF-I
    Study

    cattlen: not reported in source

    Granulosa cells from heifers on two diets, cultured in vitro
    Comparator
    Maintenance diet
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health

    Source sentences

    Summary
    The effect was apparent in either the presence or absence of FSH and long R3-IGF-I.
    2 context sentences
    Summary · context
    Hereford x Friesian heifers (n = 24) were offered maintenance or twice maintenance diets during the experimental period (17 days).
    Summary · context
    Granulosa cells were isolated from small (1-4 mm) and medium-sized (4-8 mm) follicles and cultured in the presence of long R3-IGF-I or bFSH or both.

    In this study, IGF-1 LR3 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking IGF-1 LR3.

  4. 04AnimalNot a test of IGF-1 LR3 aloneAnimal study (in vivo)Efficacy outcome

    In granulosa cells, the nutritional effect on aromatase activity was not apparent after day 6 of culture.

    In plain wordsIn cow ovary cells, the diet effect on aromatase activity was no longer seen after 6 days in culture.

    Peptide
    IGF-1 LR3
    Outcome
    No significant changeDiet effect on aromatase activity after day 6
    Study

    cattlen: not reported in source

    Granulosa cells from heifers on two diets, cultured in vitro
    Comparator
    Maintenance diet
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health

    Source sentences

    Summary
    This nutritional effect on aromatase activity in granulosa cells was not apparent after day 6 of culture.
    2 context sentences
    Summary · context
    Hereford x Friesian heifers (n = 24) were offered maintenance or twice maintenance diets during the experimental period (17 days).
    Summary · context
    Granulosa cells were isolated from small (1-4 mm) and medium-sized (4-8 mm) follicles and cultured in the presence of long R3-IGF-I or bFSH or both.

    In this study, IGF-1 LR3 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking IGF-1 LR3.

  5. 05AnimalNot a test of IGF-1 LR3 aloneAnimal study (in vivo)Efficacy outcome

    In granulosa cells, diet had no effect on progesterone production after 4 or 6 days of culture.

    In plain wordsIn cow ovary cells, the diet did not change progesterone production.

    Peptide
    IGF-1 LR3
    Outcome
    No significant changeProgesterone production
    Study

    cattlen: not reported in source

    Granulosa cells from heifers on two diets, cultured in vitro
    Comparator
    Maintenance diet
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health

    Source sentences

    Summary
    There was no effect of diet on progesterone production by granulosa cells after 4 or 6 days of culture.
    2 context sentences
    Summary · context
    Hereford x Friesian heifers (n = 24) were offered maintenance or twice maintenance diets during the experimental period (17 days).
    Summary · context
    Granulosa cells were isolated from small (1-4 mm) and medium-sized (4-8 mm) follicles and cultured in the presence of long R3-IGF-I or bFSH or both.

    In this study, IGF-1 LR3 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking IGF-1 LR3.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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