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Study · In vitro (cells) · 2002

1 result

Protective role of retinoic acid from antiproliferative action of TNF-alpha on lung epithelial cells.

Besnard V, Nabeyrat E, Henrion-Caude A, Chadelat K, Perin L, Le Bouc Y, Clement A

American journal of physiology. Lung cellular and molecular physiology1 Apr 2002Cited by 24 (Europe PMC)

PMID11880314 (opens in a new tab)DOI10.1152/ajplung.00368.2001 (opens in a new tab)PepBankPUB-11880314
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study1

1 result from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Efficacy outcome

    In alveolar epithelial cells exposed to TNF-alpha, des(1‑3)IGF-I restored cell growth whereas IGF-I did not stimulate proliferation.

    In plain wordsIn cells exposed to TNF-alpha, des(1‑3)IGF-I restored lung epithelial cell growth whereas IGF-I did not.

    Peptide
    IGF-1 DES (des(1-3)IGF-I)
    Outcome
    IncreaseCell growth restoration
    Study

    n: not reported in source

    lung alveolar epithelial cells
    Comparator
    TNF-alpha-containing medium with IGF-I
    Outcome group
    Cell proliferation and differentiation · Respiratory
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Addition of IGF-I to the TNF-alpha containing medium did not stimulate proliferation, whereas des(1-3)IGF-I, an analog of IGF-I that bears low affinity for IGFBPs, was able to restore cell growth.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 2

    21 Oct 2026, 13:52 UTC

    Study data updated · source update from Europe PMC

  3. Version 1

    21 Oct 2026, 12:50 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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