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Study · Animal study (in vivo) · rat · 2002

10 results

Effect of AICAR treatment on glycogen metabolism in skeletal muscle.

Aschenbach WG, Hirshman MF, Fujii N, Sakamoto K, Howlett KF, Goodyear LJ

Diabetes1 Mar 2002Cited by 94 (Europe PMC)

PMID11872652 (opens in a new tab)DOI10.2337/diabetes.51.3.567 (opens in a new tab)PepBankPUB-11872652
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study10

10 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Mechanism

    In rats, AICAR reduced blood glucose from basal values.

    In plain wordsIn rats, AICAR reduced blood sugar from starting values.

    Peptide
    AICAR (acadesine)
    Outcome
    DecreaseBlood glucose
    Study

    ratn: not reported in source

    red and white gastrocnemius
    Comparator
    Basal values
    Outcome group
    Glycemic control · Metabolic and weight
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In vivo AICAR treatment reduced blood glucose and increased blood lactate compared with basal values.
    1 context sentence
    Summary · context
    AMPK activity and glycogen metabolism were studied in red and white gastrocnemius muscles from rats treated with 5-aminoimidazole-4-carboxamide ribonucleoside (AICAR) in vivo, and also in muscles incubated with AICAR in vitro.
  2. 02AnimalAnimal study (in vivo)Mechanism

    In rats, AICAR increased blood lactate from basal values.

    In plain wordsIn rats, AICAR increased blood lactate from starting values.

    Peptide
    AICAR (acadesine)
    Outcome
    IncreaseBlood lactate
    Study

    ratn: not reported in source

    red and white gastrocnemius
    Comparator
    Basal values
    Outcome group
    Glycemic control · Metabolic and weight
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In vivo AICAR treatment reduced blood glucose and increased blood lactate compared with basal values.
    1 context sentence
    Summary · context
    AMPK activity and glycogen metabolism were studied in red and white gastrocnemius muscles from rats treated with 5-aminoimidazole-4-carboxamide ribonucleoside (AICAR) in vivo, and also in muscles incubated with AICAR in vitro.
  3. 03AnimalAnimal study (in vivo)Mechanism

    In rat muscles, AICAR increased alpha2 AMPK activity.

    In plain wordsIn rats, AICAR increased muscle AMPK enzyme activity.

    Peptide
    AICAR (acadesine)
    Outcome
    IncreaseMuscle alpha2 AMPK activity
    Study

    ratn: not reported in source

    red and white gastrocnemius
    Outcome group
    Receptor activity and mechanism · Musculoskeletal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    AICAR increased muscle alpha2 AMPK activity, glycogen, and glucose-6-phosphate concentrations.
    1 context sentence
    Summary · context
    AMPK activity and glycogen metabolism were studied in red and white gastrocnemius muscles from rats treated with 5-aminoimidazole-4-carboxamide ribonucleoside (AICAR) in vivo, and also in muscles incubated with AICAR in vitro.
  4. 04AnimalAnimal study (in vivo)Mechanism

    In rat muscles, AICAR increased glycogen concentrations.

    In plain wordsIn rats, AICAR increased stored muscle sugar.

    Peptide
    AICAR (acadesine)
    Outcome
    IncreaseMuscle glycogen
    Study

    ratn: not reported in source

    red and white gastrocnemius
    Outcome group
    Glycemic control · Musculoskeletal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    AICAR increased muscle alpha2 AMPK activity, glycogen, and glucose-6-phosphate concentrations.
    1 context sentence
    Summary · context
    AMPK activity and glycogen metabolism were studied in red and white gastrocnemius muscles from rats treated with 5-aminoimidazole-4-carboxamide ribonucleoside (AICAR) in vivo, and also in muscles incubated with AICAR in vitro.
  5. 05AnimalAnimal study (in vivo)Mechanism

    In rat muscles, AICAR increased glucose-6-phosphate concentrations.

    In plain wordsIn rats, AICAR increased muscle glucose-6-phosphate.

    Peptide
    AICAR (acadesine)
    Outcome
    IncreaseMuscle glucose-6-phosphate
    Study

    ratn: not reported in source

    red and white gastrocnemius
    Outcome group
    Glycemic control · Musculoskeletal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    AICAR increased muscle alpha2 AMPK activity, glycogen, and glucose-6-phosphate concentrations.
    1 context sentence
    Summary · context
    AMPK activity and glycogen metabolism were studied in red and white gastrocnemius muscles from rats treated with 5-aminoimidazole-4-carboxamide ribonucleoside (AICAR) in vivo, and also in muscles incubated with AICAR in vitro.
  6. 06AnimalAnimal study (in vivo)Mechanism

    In rats, AICAR increased glycogen synthase activity in red gastrocnemius but decreased it in white gastrocnemius.

    In plain wordsIn rats, AICAR increased glycogen synthase activity in red muscle but reduced it in white muscle.

    Peptide
    AICAR (acadesine)
    Outcome
    MixedGlycogen synthase activity
    Study

    ratn: not reported in source

    red and white gastrocnemius
    Outcome group
    Glycemic control · Musculoskeletal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Glycogen synthase activity was increased in the red gastrocnemius but was decreased in the white gastrocnemius.
    1 context sentence
    Summary · context
    AMPK activity and glycogen metabolism were studied in red and white gastrocnemius muscles from rats treated with 5-aminoimidazole-4-carboxamide ribonucleoside (AICAR) in vivo, and also in muscles incubated with AICAR in vitro.
  7. 07AnimalAnimal study (in vivo)Mechanism

    In rats, AICAR increased glycogen phosphorylase activity in both muscles, after initial inhibition in red gastrocnemius.

    In plain wordsIn rats, AICAR increased glycogen phosphorylase activity in both muscles, with initial inhibition in red muscle.

    Peptide
    AICAR (acadesine)
    Outcome
    MixedGlycogen phosphorylase activity
    Study

    ratn: not reported in source

    red and white gastrocnemius
    Outcome group
    Glycemic control · Musculoskeletal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Glycogen phosphorylase activity increased in both muscles, with an inhibition initially observed in the red gastrocnemius.
    1 context sentence
    Summary · context
    AMPK activity and glycogen metabolism were studied in red and white gastrocnemius muscles from rats treated with 5-aminoimidazole-4-carboxamide ribonucleoside (AICAR) in vivo, and also in muscles incubated with AICAR in vitro.
  8. 08LabEx vivo tissueMechanism

    In isolated rat muscles, AICAR activated alpha2 AMPK.

    In plain wordsIn lab tests, AICAR activated AMPK in rat muscle.

    Peptide
    AICAR (acadesine)
    Outcome
    IncreaseIn vitro alpha2 AMPK activity
    Study

    ratn: not reported in source

    red and white gastrocnemius
    Outcome group
    Receptor activity and mechanism · Musculoskeletal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In vitro incubation with AICAR activated alpha2 AMPK but had no effect on either glycogen synthase or glycogen phosphorylase.
    1 context sentence
    Summary · context
    AMPK activity and glycogen metabolism were studied in red and white gastrocnemius muscles from rats treated with 5-aminoimidazole-4-carboxamide ribonucleoside (AICAR) in vivo, and also in muscles incubated with AICAR in vitro.
  9. 09LabEx vivo tissueMechanism

    In isolated rat muscles, AICAR did not affect glycogen synthase.

    In plain wordsIn lab tests, AICAR did not affect glycogen synthase in rat muscle.

    Peptide
    AICAR (acadesine)
    Outcome
    No significant changeIn vitro glycogen synthase
    Study

    ratn: not reported in source

    red and white gastrocnemius
    Outcome group
    Glycemic control · Musculoskeletal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In vitro incubation with AICAR activated alpha2 AMPK but had no effect on either glycogen synthase or glycogen phosphorylase.
    1 context sentence
    Summary · context
    AMPK activity and glycogen metabolism were studied in red and white gastrocnemius muscles from rats treated with 5-aminoimidazole-4-carboxamide ribonucleoside (AICAR) in vivo, and also in muscles incubated with AICAR in vitro.
  10. 10LabEx vivo tissueMechanism

    In isolated rat muscles, AICAR did not affect glycogen phosphorylase.

    In plain wordsIn lab tests, AICAR did not affect glycogen phosphorylase in rat muscle.

    Peptide
    AICAR (acadesine)
    Outcome
    No significant changeIn vitro glycogen phosphorylase
    Study

    ratn: not reported in source

    red and white gastrocnemius
    Outcome group
    Glycemic control · Musculoskeletal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In vitro incubation with AICAR activated alpha2 AMPK but had no effect on either glycogen synthase or glycogen phosphorylase.
    1 context sentence
    Summary · context
    AMPK activity and glycogen metabolism were studied in red and white gastrocnemius muscles from rats treated with 5-aminoimidazole-4-carboxamide ribonucleoside (AICAR) in vivo, and also in muscles incubated with AICAR in vitro.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 12:50 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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