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Study · Animal study (in vivo) · cats and cat · 2001

3 results

[Effect of nootropic agents on impulse activity of cerebral cortex neurons].

Iasnetsov VV, Pravdivtsev VA, Krylova IN, Kozlov SB, Provornova NA, Ivanov IuV, Iasnetsov VV

Eksperimental'naia i klinicheskaia farmakologiia1 Nov 2001

PMID11871233 (opens in a new tab)PepBankPUB-11871233
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Activity measurement

    In immobilized cats, semax inhibited the activity of cerebral cortex neurons in more than half of cases.

    In plain wordsIn cats, semax reduced the activity of brain cortex nerve cells in more than half of cases.

    Peptide
    Semax
    Outcome
    DecreaseInhibition of cortical neuron activity
    Study

    catsn: not reported in source

    Immobilized cats, cerebral cortex neurons, microelectrode and microionophoresis
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The inhibiting effect of semax and GVS-111 upon neurons in more than half of cases
    1 context sentence
    Summary · context
    The effect of nootropes (semax, mexidol, and GVS-111) on the activity of individual neurons in various cerebral cortex regions was studied by microelectrode and microionophoresis techniques in cats immobilized by myorelaxants.
  2. 02AnimalAnimal study (in vivo)Mechanism

    In immobilized cats, the inhibiting effect of semax on cortical neurons was related to stimulation of M-choline receptors.

    In plain wordsIn cats, the nerve-cell inhibition by semax was linked to stimulation of M-choline receptors.

    Peptide
    Semax
    Outcome
    Not applicableReceptor mechanism of neuronal inhibition
    Study

    catsn: not reported in source

    Immobilized cats, cerebral cortex neurons, microelectrode and microionophoresis
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The inhibiting effect of semax and GVS-111 upon neurons in more than half of cases is related to stimulation of the M-choline and NMDA receptors, respectively.
    1 context sentence
    Summary · context
    The effect of nootropes (semax, mexidol, and GVS-111) on the activity of individual neurons in various cerebral cortex regions was studied by microelectrode and microionophoresis techniques in cats immobilized by myorelaxants.
  3. 03AnimalAnimal study (in vivo)Mechanism

    In immobilized cats, GVS-111 inhibited cortical neurons, with NMDA receptor stimulation implicated in more than half of cases.

    In plain wordsIn cats, GVS-111 inhibited brain cortex neurons, with NMDA receptor stimulation implicated in more than half of cases.

    Peptide
    Noopept (omberacetam)
    Outcome
    DecreaseNMDA-associated inhibition of cortical neuronal activity
    Study

    catn: not reported in source

    Cats immobilized by myorelaxants
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated · microionophoresisAs given in this study (cat).

    Source sentences

    Summary
    The inhibiting effect of semax and GVS-111 upon neurons in more than half of cases is related to stimulation of the M-choline and NMDA receptors, respectively.
    1 context sentence
    Summary · context
    The effect of nootropes (semax, mexidol, and GVS-111) on the activity of individual neurons in various cerebral cortex regions was studied by microelectrode and microionophoresis techniques in cats immobilized by myorelaxants.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Versions 4 to 12Current

    28 Oct 2026, 02:02 UTC

    The same notice was added 9 times, first on 21 Oct 2026, 15:59 UTC. The status did not change between them.

    Study results updated

  2. Version 3

    21 Oct 2026, 12:50 UTC

    Study data updated · source update from Europe PMC

  3. Version 2

    12 Oct 2026, 17:28 UTC

    Study results updated

  4. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

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