Modulatory effects of gonadotrophins and insulin-like growth factor on the secretion of inhibin A and progesterone by granulosa cells from chicken preovulatory (F1-F3) follicles.

Lovell TM, Gladwell RT, Groome NP, Knight PG

Reproduction (Cambridge, England)1 Feb 2002Cited by 17 (Europe PMC)

PMID11866696DOI10.1530/rep.0.1230291PepBankPUB-11866696

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study9

9 results from studies that gave the peptide. No result from this study comes from people.

01LabIn vitro (cells)Activity measurement
In cultured chicken granulosa cells, F1 cells were initially more responsive to LR3-IGF-I than F3 cells in progesterone secretion.
In plain wordsIn chicken follicle cells, cells from the largest follicle first made more progesterone in response to LR3-IGF-I than cells from the third follicle.
Peptide
IGF-1 LR3
Outcome
Not applicableProgesterone response to LR3-IGF-I, F1 versus F3 cells
Study
chickenn: not reported in source
Cultured granulosa cells from preovulatory follicles F1-F3
Comparator
F3 follicle cells
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
Dose not stated
Source sentences
Summary
Initially, F1 cells were more responsive to LR3-IGF-I than were F3 cells in terms of progesterone secretion (P < 0.001)
1 context sentence(design, population, supporting numbers)
Summary · context
The aim of this study was to compare the actions and interactions of gonadotrophins (LH and FSH) and an analogue of insulin-like growth factor I (LR3-IGF-I) on the secretion of inhibin A, inhibin B and progesterone by cultured chicken granulosa cells derived from the three largest (F1--F3) follicles…
Report a problemFND-1186669601
02LabIn vitro (cells)Activity measurement
In cultured chicken granulosa cells, F1 cells were initially less responsive to LR3-IGF-I than F3 cells in inhibin A secretion.
In plain wordsIn chicken follicle cells, cells from the largest follicle first made less inhibin A in response to LR3-IGF-I than cells from the third follicle.
Peptide
IGF-1 LR3
Outcome
Not applicableInhibin A response to LR3-IGF-I, F1 versus F3 cells
Study
chickenn: not reported in source
Cultured granulosa cells from preovulatory follicles F1-F3
Comparator
F3 follicle cells
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
Dose not stated
Source sentences
Summary
but were less responsive in terms of inhibin A secretion (P < 0.001).
1 context sentence(design, population, supporting numbers)
Summary · context
The aim of this study was to compare the actions and interactions of gonadotrophins (LH and FSH) and an analogue of insulin-like growth factor I (LR3-IGF-I) on the secretion of inhibin A, inhibin B and progesterone by cultured chicken granulosa cells derived from the three largest (F1--F3) follicles…
Report a problemFND-1186669602
03LabIn vitro (cells)Activity measurement
In cultured chicken granulosa cells, LR3-IGF-I enhanced LH-induced inhibin A secretion over time and by follicle.
In plain wordsIn chicken follicle cells, LR3-IGF-I boosted the inhibin A response to LH.
Peptide
IGF-1 LR3
Outcome
IncreaseLH-induced inhibin A secretion with LR3-IGF-I
Study
chickenn: not reported in source
Cultured granulosa cells from preovulatory follicles F1-F3
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
Dose not stated
Source sentences
Summary
Co-treatment experiments showed that LR3-IGF-I enhanced both LH- and FSH-induced secretion of inhibin A and progesterone in a time- (P < 0.001) and follicle- (P < 0.001) dependent way.
1 context sentence(design, population, supporting numbers)
Summary · context
The aim of this study was to compare the actions and interactions of gonadotrophins (LH and FSH) and an analogue of insulin-like growth factor I (LR3-IGF-I) on the secretion of inhibin A, inhibin B and progesterone by cultured chicken granulosa cells derived from the three largest (F1--F3) follicles…
Report a problemFND-1186669603
04LabIn vitro (cells)Activity measurement
In cultured chicken granulosa cells, LR3-IGF-I enhanced FSH-induced inhibin A secretion over time and by follicle.
In plain wordsIn chicken follicle cells, LR3-IGF-I boosted the inhibin A response to FSH.
Peptide
IGF-1 LR3
Outcome
IncreaseFSH-induced inhibin A secretion with LR3-IGF-I
Study
chickenn: not reported in source
Cultured granulosa cells from preovulatory follicles F1-F3
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
Dose not stated
Source sentences
Summary
Co-treatment experiments showed that LR3-IGF-I enhanced both LH- and FSH-induced secretion of inhibin A and progesterone in a time- (P < 0.001) and follicle- (P < 0.001) dependent way.
1 context sentence(design, population, supporting numbers)
Summary · context
The aim of this study was to compare the actions and interactions of gonadotrophins (LH and FSH) and an analogue of insulin-like growth factor I (LR3-IGF-I) on the secretion of inhibin A, inhibin B and progesterone by cultured chicken granulosa cells derived from the three largest (F1--F3) follicles…
Report a problemFND-1186669604
05LabIn vitro (cells)Activity measurement
In cultured chicken granulosa cells, LR3-IGF-I enhanced LH-induced progesterone secretion over time and by follicle.
In plain wordsIn chicken follicle cells, LR3-IGF-I boosted the progesterone response to LH.
Peptide
IGF-1 LR3
Outcome
IncreaseLH-induced progesterone secretion with LR3-IGF-I
Study
chickenn: not reported in source
Cultured granulosa cells from preovulatory follicles F1-F3
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
Dose not stated
Source sentences
Summary
Co-treatment experiments showed that LR3-IGF-I enhanced both LH- and FSH-induced secretion of inhibin A and progesterone in a time- (P < 0.001) and follicle- (P < 0.001) dependent way.
1 context sentence(design, population, supporting numbers)
Summary · context
The aim of this study was to compare the actions and interactions of gonadotrophins (LH and FSH) and an analogue of insulin-like growth factor I (LR3-IGF-I) on the secretion of inhibin A, inhibin B and progesterone by cultured chicken granulosa cells derived from the three largest (F1--F3) follicles…
Report a problemFND-1186669605
06LabIn vitro (cells)Activity measurement
In cultured chicken granulosa cells, LR3-IGF-I enhanced FSH-induced progesterone secretion over time and by follicle.
In plain wordsIn chicken follicle cells, LR3-IGF-I boosted the progesterone response to FSH.
Peptide
IGF-1 LR3
Outcome
IncreaseFSH-induced progesterone secretion with LR3-IGF-I
Study
chickenn: not reported in source
Cultured granulosa cells from preovulatory follicles F1-F3
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
Dose not stated
Source sentences
Summary
Co-treatment experiments showed that LR3-IGF-I enhanced both LH- and FSH-induced secretion of inhibin A and progesterone in a time- (P < 0.001) and follicle- (P < 0.001) dependent way.
1 context sentence(design, population, supporting numbers)
Summary · context
The aim of this study was to compare the actions and interactions of gonadotrophins (LH and FSH) and an analogue of insulin-like growth factor I (LR3-IGF-I) on the secretion of inhibin A, inhibin B and progesterone by cultured chicken granulosa cells derived from the three largest (F1--F3) follicles…
Report a problemFND-1186669606
07LabIn vitro (cells)Activity measurement
In cultured chicken granulosa cells, F1 cells showed the highest LR3-IGF-I enhancement of LH-induced inhibin A and progesterone secretion.
In plain wordsIn chicken follicle cells, the largest follicle's cells showed the strongest LR3-IGF-I boost of the LH response.
Peptide
IGF-1 LR3
Outcome
Not applicableFollicle differences in LR3-IGF-I enhancement of LH-induced responses
Study
chickenn: not reported in source
Cultured granulosa cells from preovulatory follicles F1-F3
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
Dose not stated
Source sentences
Summary
Initially, F1 cells showed highest LR3-IGF-I enhancement of LH-induced inhibin A and progesterone secretion
1 context sentence(design, population, supporting numbers)
Summary · context
The aim of this study was to compare the actions and interactions of gonadotrophins (LH and FSH) and an analogue of insulin-like growth factor I (LR3-IGF-I) on the secretion of inhibin A, inhibin B and progesterone by cultured chicken granulosa cells derived from the three largest (F1--F3) follicles…
Report a problemFND-1186669607
08LabIn vitro (cells)Activity measurement
In cultured chicken granulosa cells, F3 cells showed the highest LR3-IGF-1 enhancement of FSH-induced inhibin A and progesterone secretion.
In plain wordsIn chicken follicle cells, the third follicle's cells showed the strongest LR3-IGF-1 boost of the FSH response.
Peptide
IGF-1 LR3
Outcome
Not applicableFollicle differences in LR3-IGF-I enhancement of FSH-induced responses
Study
chickenn: not reported in source
Cultured granulosa cells from preovulatory follicles F1-F3
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
Dose not stated
Source sentences
Summary
in contrast, F3 cells showed the highest LR3- IGF-1 enhancement of FSH-induced inhibin A and progesterone secretion.
1 context sentence(design, population, supporting numbers)
Summary · context
The aim of this study was to compare the actions and interactions of gonadotrophins (LH and FSH) and an analogue of insulin-like growth factor I (LR3-IGF-I) on the secretion of inhibin A, inhibin B and progesterone by cultured chicken granulosa cells derived from the three largest (F1--F3) follicles…
Report a problemFND-1186669608
09LabIn vitro (cells)Activity measurement
In cultured chicken granulosa cells, the relative degree of LR3-IGF-I enhancement increased markedly over time in culture.
In plain wordsIn chicken follicle cells, the boost from LR3-IGF-I grew larger the longer the cells stayed in culture.
Peptide
IGF-1 LR3
Outcome
IncreaseChange in LR3-IGF-I enhancement over time in culture
Study
chickenn: not reported in source
Cultured granulosa cells from preovulatory follicles F1-F3
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
Dose not stated
Source sentences
Summary
even though the relative degree of LR3-IGF-I enhancement increased markedly over time.
1 context sentence(design, population, supporting numbers)
Summary · context
The aim of this study was to compare the actions and interactions of gonadotrophins (LH and FSH) and an analogue of insulin-like growth factor I (LR3-IGF-I) on the secretion of inhibin A, inhibin B and progesterone by cultured chicken granulosa cells derived from the three largest (F1--F3) follicles…
Report a problemFND-1186669609

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
13 Oct 2026, 21:44 UTC
Study results updated
Version 1
13 Oct 2026, 16:31 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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