Effects of thymic hormone on reactive oxygen species-scavengers and renal function in tacrolimus-induced nephrotoxicity.

Tada H, Nakashima A, Awaya A, Fujisaki A, Inoue K, Kawamura K, Itoh K, Masuda H, Suzuki T

Life sciences1 Jan 2002Cited by 14 (Europe PMC)

PMID11848304DOI10.1016/s0024-3205(01)01495-3PepBankPUB-11848304

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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

5 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Efficacy outcome
In tacrolimus-treated rats, each FTS dose (5, 50, and 250 microg/kg/day) partially elevated renal creatinine clearance.
In plain wordsIn rats receiving tacrolimus, each tested FTS dose partly increased kidney clearance compared with tacrolimus alone.
Peptide
Thymulin (serum thymic factor)
Outcome
IncreaseRenal creatinine clearance
Study
ratn: not reported in source
Heminephrectomized rats with or without tacrolimus nephrotoxicity
Comparator
Tacrolimus without FTS
Outcome group
Kidney function · Kidney and urinary
Studied dose
5, 50, and 250 microg/kg/day · subcutaneous · 28 daysAs given in this study (rat).
Source sentences
Summary
Each dose of FTS (Group A) partially elevated renal creatinine clearances.
3 context sentences(design, population, supporting numbers)
Summary · context
Rats received both oral dose of tacrolimus (5 mg/kg/day) and subcutaneous administration of three dosages of FTS (5, 50, and 250 microg/kg/day) over 28 days (Group A).
Summary · context
The effects of a thymic hormone (Facteur thymique serique; FTS) on renal reactive oxygen species-scavenging enzymes or substances in heminephrectomized rats with and without tacrolimus-induced nephrotoxicity were studied.
Summary · context
In Group B, they received three dosages of FTS alone (0.5, 5, and 50 microg/kg/day) or FTS 50 microg/kg/day with tacrolimus over 28 days.
Report a problemFND-1184830401
02AnimalAnimal study (in vivo)Mechanism
In heminephrectomized rats, FTS increased renal glutathione levels.
In plain wordsIn rats, FTS increased kidney glutathione levels.
Peptide
Thymulin (serum thymic factor)
Outcome
IncreaseRenal glutathione levels
Study
ratn: not reported in source
Heminephrectomized rats with or without tacrolimus nephrotoxicity
Outcome group
Kidney function · Kidney and urinary
Studied dose
Dose not stated · subcutaneous · 28 daysAs given in this study (rat).
Source sentences
Summary
FTS increased GSH levels and GSH-R activities.
3 context sentences(design, population, supporting numbers)
Summary · context
The effects of a thymic hormone (Facteur thymique serique; FTS) on renal reactive oxygen species-scavenging enzymes or substances in heminephrectomized rats with and without tacrolimus-induced nephrotoxicity were studied.
Summary · context
Rats received both oral dose of tacrolimus (5 mg/kg/day) and subcutaneous administration of three dosages of FTS (5, 50, and 250 microg/kg/day) over 28 days (Group A).
Summary · context
In Group B, they received three dosages of FTS alone (0.5, 5, and 50 microg/kg/day) or FTS 50 microg/kg/day with tacrolimus over 28 days.
Report a problemFND-1184830402
03AnimalAnimal study (in vivo)Mechanism
In heminephrectomized rats, FTS increased renal glutathione reductase activity.
In plain wordsIn rats, FTS increased kidney glutathione reductase activity.
Peptide
Thymulin (serum thymic factor)
Outcome
IncreaseRenal glutathione reductase activity
Study
ratn: not reported in source
Heminephrectomized rats with or without tacrolimus nephrotoxicity
Outcome group
Kidney function · Kidney and urinary
Studied dose
Dose not stated · subcutaneous · 28 daysAs given in this study (rat).
Source sentences
Summary
FTS increased GSH levels and GSH-R activities.
3 context sentences(design, population, supporting numbers)
Summary · context
The effects of a thymic hormone (Facteur thymique serique; FTS) on renal reactive oxygen species-scavenging enzymes or substances in heminephrectomized rats with and without tacrolimus-induced nephrotoxicity were studied.
Summary · context
Rats received both oral dose of tacrolimus (5 mg/kg/day) and subcutaneous administration of three dosages of FTS (5, 50, and 250 microg/kg/day) over 28 days (Group A).
Summary · context
In Group B, they received three dosages of FTS alone (0.5, 5, and 50 microg/kg/day) or FTS 50 microg/kg/day with tacrolimus over 28 days.
Report a problemFND-1184830403
04AnimalAnimal study (in vivo)Mechanism
In heminephrectomized rats, FTS alone did not change renal catalase activity.
In plain wordsIn rats, FTS alone did not change kidney catalase activity.
Peptide
Thymulin (serum thymic factor)
Outcome
No significant changeCatalase activity with FTS alone
Study
ratn: not reported in source
Heminephrectomized rats with or without tacrolimus nephrotoxicity
Outcome group
Kidney function · Kidney and urinary
Studied dose
Dose not stated · subcutaneous · 28 daysAs given in this study (rat).
Source sentences
Summary
Although FTS alone did not change CAT activities, CAT activities recovered as a result of concomitant use of FTS (Groups A and B).
3 context sentences(design, population, supporting numbers)
Summary · context
The effects of a thymic hormone (Facteur thymique serique; FTS) on renal reactive oxygen species-scavenging enzymes or substances in heminephrectomized rats with and without tacrolimus-induced nephrotoxicity were studied.
Summary · context
Rats received both oral dose of tacrolimus (5 mg/kg/day) and subcutaneous administration of three dosages of FTS (5, 50, and 250 microg/kg/day) over 28 days (Group A).
Summary · context
In Group B, they received three dosages of FTS alone (0.5, 5, and 50 microg/kg/day) or FTS 50 microg/kg/day with tacrolimus over 28 days.
Report a problemFND-1184830404
05AnimalAnimal study (in vivo)Mechanism
In tacrolimus-treated rats, concomitant FTS restored renal catalase activity.
In plain wordsIn rats, FTS restored kidney catalase activity compared with tacrolimus alone.
Peptide
Thymulin (serum thymic factor)
Outcome
IncreaseCatalase activity during tacrolimus treatment
Study
ratn: not reported in source
Heminephrectomized rats with or without tacrolimus nephrotoxicity
Comparator
Tacrolimus without FTS
Outcome group
Kidney function · Kidney and urinary
Studied dose
Dose not stated · subcutaneous · 28 daysAs given in this study (rat).
Source sentences
Summary
Although FTS alone did not change CAT activities, CAT activities recovered as a result of concomitant use of FTS (Groups A and B).
3 context sentences(design, population, supporting numbers)
Summary · context
The effects of a thymic hormone (Facteur thymique serique; FTS) on renal reactive oxygen species-scavenging enzymes or substances in heminephrectomized rats with and without tacrolimus-induced nephrotoxicity were studied.
Summary · context
Rats received both oral dose of tacrolimus (5 mg/kg/day) and subcutaneous administration of three dosages of FTS (5, 50, and 250 microg/kg/day) over 28 days (Group A).
Summary · context
In Group B, they received three dosages of FTS alone (0.5, 5, and 50 microg/kg/day) or FTS 50 microg/kg/day with tacrolimus over 28 days.
Report a problemFND-1184830405

Studies that did not test the peptide alone1

In this study, Thymulin (serum thymic factor) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Thymulin (serum thymic factor).

06AnimalNot a test of Thymulin (serum thymic factor) aloneAnimal study (in vivo)Mechanism
In heminephrectomized rats studied with FTS, catalase activity correlated positively with creatinine clearance.
In plain wordsIn rats studied with FTS, higher catalase activity was linked to greater kidney clearance.
Peptide
Thymulin (serum thymic factor)
Outcome
IncreaseCatalase activity correlation with creatinine clearance
Study
ratn: not reported in source
Heminephrectomized rats with or without tacrolimus nephrotoxicity
Outcome group
Kidney function · Kidney and urinary
Source sentences
Summary
A significant positive correlation was found between CAT activity and creatinine clearance.
3 context sentences(design, population, supporting numbers)
Summary · context
The effects of a thymic hormone (Facteur thymique serique; FTS) on renal reactive oxygen species-scavenging enzymes or substances in heminephrectomized rats with and without tacrolimus-induced nephrotoxicity were studied.
Summary · context
Rats received both oral dose of tacrolimus (5 mg/kg/day) and subcutaneous administration of three dosages of FTS (5, 50, and 250 microg/kg/day) over 28 days (Group A).
Summary · context
In Group B, they received three dosages of FTS alone (0.5, 5, and 50 microg/kg/day) or FTS 50 microg/kg/day with tacrolimus over 28 days.
In this study, Thymulin (serum thymic factor) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymulin (serum thymic factor).
Report a problemFND-1184830406

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
21 Oct 2026, 15:58 UTC
Study results updated
Version 1
21 Oct 2026, 12:50 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

Journal Article

MeSH terms

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