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Study · Animal study (in vivo) · rat · 2002

4 results

Chronic infusion of a melanocortin receptor agonist modulates dopamine receptor binding in the rat brain.

Lindblom J, Kask A, Hägg E, Härmark L, Bergström L, Wikberg J

Pharmacological research1 Feb 2002Cited by 33 (Europe PMC)

PMID11846623 (opens in a new tab)DOI10.1006/phrs.2001.0913 (opens in a new tab)PepBankPUB-11846623
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Mechanism

    In rats, 2-week intracerebroventricular melanotan II infusion increased D1-like dopamine receptor binding in the nucleus accumbens and the caudate putamen.

    In plain wordsIn rats, long infusion of melanotan II into the brain raised dopamine D1-like receptor binding in two brain regions.

    Peptide
    Melanotan II
    Outcome
    IncreaseD1-like receptor binding in nucleus accumbens and caudate putamen
    Study

    ratn: not reported in source

    Rat brain autoradiography after chronic ICV infusion
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated · intracerebroventricular infusion · 2 weeksAs given in this study (rat).

    Source sentences

    Summary
    D(1)-like receptor binding was increased in the nucleus accumbens and the caudate putamen, but reduced in the substantia nigra (reticular part), whereas D(2)-like receptor binding was reduced in the caudate putamen, but increased in the periaqueductal grey, substantia nigra (compact part) and the ve…
    1 context sentence
    Summary · context
    Using an autoradiographic approach we found that a 2 week intracerebroventricular infusion of the melanocortin receptor agonist melanotan-II induced changes in dopamine D(1)-like and D(2)-like receptor binding in several regions of the rat brain.
  2. 02AnimalAnimal study (in vivo)Mechanism

    In rats, 2-week intracerebroventricular melanotan II infusion reduced D1-like dopamine receptor binding in the substantia nigra (reticular part).

    In plain wordsIn rats, long infusion of melanotan II into the brain lowered dopamine D1-like receptor binding in one brain region.

    Peptide
    Melanotan II
    Outcome
    DecreaseD1-like receptor binding in substantia nigra reticular part
    Study

    ratn: not reported in source

    Rat brain autoradiography after chronic ICV infusion
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated · intracerebroventricular infusion · 2 weeksAs given in this study (rat).

    Source sentences

    Summary
    D(1)-like receptor binding was increased in the nucleus accumbens and the caudate putamen, but reduced in the substantia nigra (reticular part), whereas D(2)-like receptor binding was reduced in the caudate putamen, but increased in the periaqueductal grey, substantia nigra (compact part) and the ve…
    1 context sentence
    Summary · context
    Using an autoradiographic approach we found that a 2 week intracerebroventricular infusion of the melanocortin receptor agonist melanotan-II induced changes in dopamine D(1)-like and D(2)-like receptor binding in several regions of the rat brain.
  3. 03AnimalAnimal study (in vivo)Mechanism

    In rats, 2-week intracerebroventricular melanotan II infusion reduced D2-like dopamine receptor binding in the caudate putamen.

    In plain wordsIn rats, long infusion of melanotan II into the brain lowered dopamine D2-like receptor binding in the caudate putamen.

    Peptide
    Melanotan II
    Outcome
    DecreaseD2-like receptor binding in caudate putamen
    Study

    ratn: not reported in source

    Rat brain autoradiography after chronic ICV infusion
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated · intracerebroventricular infusion · 2 weeksAs given in this study (rat).

    Source sentences

    Summary
    D(1)-like receptor binding was increased in the nucleus accumbens and the caudate putamen, but reduced in the substantia nigra (reticular part), whereas D(2)-like receptor binding was reduced in the caudate putamen, but increased in the periaqueductal grey, substantia nigra (compact part) and the ve…
    1 context sentence
    Summary · context
    Using an autoradiographic approach we found that a 2 week intracerebroventricular infusion of the melanocortin receptor agonist melanotan-II induced changes in dopamine D(1)-like and D(2)-like receptor binding in several regions of the rat brain.
  4. 04AnimalAnimal study (in vivo)Mechanism

    In rats, 2-week intracerebroventricular melanotan II infusion increased D2-like dopamine receptor binding in the periaqueductal grey, substantia nigra (compact part) and ventral tegmental area.

    In plain wordsIn rats, long infusion of melanotan II into the brain raised dopamine D2-like receptor binding in three brain regions.

    Peptide
    Melanotan II
    Outcome
    IncreaseD2-like receptor binding in periaqueductal grey, substantia nigra compact part and ventral tegmental area
    Study

    ratn: not reported in source

    Rat brain autoradiography after chronic ICV infusion
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated · intracerebroventricular infusion · 2 weeksAs given in this study (rat).

    Source sentences

    Summary
    D(1)-like receptor binding was increased in the nucleus accumbens and the caudate putamen, but reduced in the substantia nigra (reticular part), whereas D(2)-like receptor binding was reduced in the caudate putamen, but increased in the periaqueductal grey, substantia nigra (compact part) and the ve…
    1 context sentence
    Summary · context
    Using an autoradiographic approach we found that a 2 week intracerebroventricular infusion of the melanocortin receptor agonist melanotan-II induced changes in dopamine D(1)-like and D(2)-like receptor binding in several regions of the rat brain.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    10 Oct 2026, 09:43 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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