5-Aminoimidazole-4-carboxamide ribonucleoside treatment improves glucose homeostasis in insulin-resistant diabetic (ob/ob) mice.

Song XM, Fiedler M, Galuska D, Ryder JW, Fernström M, Chibalin AV, Wallberg-Henriksson H, Zierath JR

Diabetologia1 Jan 2002Cited by 139 (Europe PMC)

PMID11845224DOI10.1007/s125-002-8245-8PepBankPUB-11845224

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study12

12 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Efficacy outcome
In ob/ob mice, short-term AICAR normalized glucose within one hour, with effects persisting over four hours.
In plain wordsIn ob/ob mice, short-term AICAR normalized blood sugar compared with vehicle.
Peptide
AICAR (acadesine)
Outcome
DecreaseAcute glucose concentrations
Study
mousen: not reported in source
ob/ob and lean mice
Comparator
Vehicle (0.9 % NaCl)
Outcome group
Glycemic control · Metabolic and weight
Studied dose
1 mg.g body wt(-1).day(-1) · subcutaneous · 1-7 daysAs given in this study (mouse).
Measurements
Onset
≤ 1 h
ob/ob mice
Persistence
> 4 h
ob/ob mice
Source sentences
Summary
Short-term 5-aminoimidazole-4-carboxamide ribonucleoside treatment normalised glucose concentrations in ob/ob mice within 1 h, with effects persisting over 4 h.
1 context sentence(design, population, supporting numbers)
Summary · context
Lean and ob/ob mice were given 5-aminoimidazole-4-carboxamide ribonucleoside (1 mg.g body wt(-1).day(-1) s.c) or 0.9 % NaCl (vehicle) for 1-7 days.
Report a problemFND-1184522401
02AnimalAnimal study (in vivo)Efficacy outcome
In ob/ob mice, daily AICAR corrected hyperglycaemia.
In plain wordsIn ob/ob mice, daily AICAR corrected high blood sugar compared with vehicle.
Peptide
AICAR (acadesine)
Outcome
DecreaseHyperglycaemia
Study
mousen: not reported in source
ob/ob and lean mice
Comparator
Vehicle (0.9 % NaCl)
Outcome group
Glycemic control · Metabolic and weight
Studied dose
1 mg.g body wt(-1).day(-1) · subcutaneous · 1 weekAs given in this study (mouse).
Source sentences
Summary
After 1 week of daily injections, 5-aminoimidazole-4-carboxamide ribonucleoside treatment corrected hyperglycaemia, improved glucose tolerance, and increased GLUT4 and hexokinase II protein expression in skeletal muscle, but had deleterious effects on plasma non-esterified fatty acids and triglycerides.
1 context sentence(design, population, supporting numbers)
Summary · context
Lean and ob/ob mice were given 5-aminoimidazole-4-carboxamide ribonucleoside (1 mg.g body wt(-1).day(-1) s.c) or 0.9 % NaCl (vehicle) for 1-7 days.
Report a problemFND-1184522402
03AnimalAnimal study (in vivo)Efficacy outcome
In ob/ob mice, daily AICAR improved glucose tolerance.
In plain wordsIn ob/ob mice, daily AICAR improved glucose tolerance compared with vehicle.
Peptide
AICAR (acadesine)
Outcome
IncreaseGlucose tolerance
Study
mousen: not reported in source
ob/ob and lean mice
Comparator
Vehicle (0.9 % NaCl)
Outcome group
Glycemic control · Metabolic and weight
Studied dose
1 mg.g body wt(-1).day(-1) · subcutaneous · 1 weekAs given in this study (mouse).
Source sentences
Summary
After 1 week of daily injections, 5-aminoimidazole-4-carboxamide ribonucleoside treatment corrected hyperglycaemia, improved glucose tolerance, and increased GLUT4 and hexokinase II protein expression in skeletal muscle, but had deleterious effects on plasma non-esterified fatty acids and triglycerides.
1 context sentence(design, population, supporting numbers)
Summary · context
Lean and ob/ob mice were given 5-aminoimidazole-4-carboxamide ribonucleoside (1 mg.g body wt(-1).day(-1) s.c) or 0.9 % NaCl (vehicle) for 1-7 days.
Report a problemFND-1184522403
04AnimalAnimal study (in vivo)Mechanism
In ob/ob mice, AICAR increased skeletal muscle GLUT4 protein expression.
In plain wordsIn ob/ob mice, AICAR increased muscle GLUT4 protein compared with vehicle.
Peptide
AICAR (acadesine)
Outcome
IncreaseGLUT4 expression
Study
mousen: not reported in source
ob/ob and lean mice
Comparator
Vehicle (0.9 % NaCl)
Outcome group
Glycemic control · Metabolic and weight
Studied dose
1 mg.g body wt(-1).day(-1) · subcutaneous · 1 weekAs given in this study (mouse).
Source sentences
Summary
After 1 week of daily injections, 5-aminoimidazole-4-carboxamide ribonucleoside treatment corrected hyperglycaemia, improved glucose tolerance, and increased GLUT4 and hexokinase II protein expression in skeletal muscle, but had deleterious effects on plasma non-esterified fatty acids and triglycerides.
1 context sentence(design, population, supporting numbers)
Summary · context
Lean and ob/ob mice were given 5-aminoimidazole-4-carboxamide ribonucleoside (1 mg.g body wt(-1).day(-1) s.c) or 0.9 % NaCl (vehicle) for 1-7 days.
Report a problemFND-1184522404
05AnimalAnimal study (in vivo)Mechanism
In ob/ob mice, AICAR increased skeletal muscle hexokinase II protein expression.
In plain wordsIn ob/ob mice, AICAR increased muscle hexokinase II protein compared with vehicle.
Peptide
AICAR (acadesine)
Outcome
IncreaseHexokinase II expression
Study
mousen: not reported in source
ob/ob and lean mice
Comparator
Vehicle (0.9 % NaCl)
Outcome group
Glycemic control · Metabolic and weight
Studied dose
1 mg.g body wt(-1).day(-1) · subcutaneous · 1 weekAs given in this study (mouse).
Source sentences
Summary
After 1 week of daily injections, 5-aminoimidazole-4-carboxamide ribonucleoside treatment corrected hyperglycaemia, improved glucose tolerance, and increased GLUT4 and hexokinase II protein expression in skeletal muscle, but had deleterious effects on plasma non-esterified fatty acids and triglycerides.
1 context sentence(design, population, supporting numbers)
Summary · context
Lean and ob/ob mice were given 5-aminoimidazole-4-carboxamide ribonucleoside (1 mg.g body wt(-1).day(-1) s.c) or 0.9 % NaCl (vehicle) for 1-7 days.
Report a problemFND-1184522405
06AnimalAnimal study (in vivo)Safety outcome
In ob/ob mice, AICAR had deleterious effects on plasma non-esterified fatty acids.
In plain wordsIn ob/ob mice, AICAR adversely affected blood non-esterified fatty acids compared with vehicle.
Peptide
AICAR (acadesine)
Outcome
Direction not reportedNon-esterified fatty acids
Study
mousen: not reported in source
ob/ob and lean mice
Comparator
Vehicle (0.9 % NaCl)
Outcome group
Lipids · Metabolic and weight
Studied dose
1 mg.g body wt(-1).day(-1) · subcutaneous · 1 weekAs given in this study (mouse).
Source sentences
Summary
After 1 week of daily injections, 5-aminoimidazole-4-carboxamide ribonucleoside treatment corrected hyperglycaemia, improved glucose tolerance, and increased GLUT4 and hexokinase II protein expression in skeletal muscle, but had deleterious effects on plasma non-esterified fatty acids and triglycerides.
1 context sentence(design, population, supporting numbers)
Summary · context
Lean and ob/ob mice were given 5-aminoimidazole-4-carboxamide ribonucleoside (1 mg.g body wt(-1).day(-1) s.c) or 0.9 % NaCl (vehicle) for 1-7 days.
Report a problemFND-1184522406
07AnimalAnimal study (in vivo)Safety outcome
In ob/ob mice, AICAR had deleterious effects on plasma triglycerides.
In plain wordsIn ob/ob mice, AICAR adversely affected blood triglycerides compared with vehicle.
Peptide
AICAR (acadesine)
Outcome
Direction not reportedTriglycerides
Study
mousen: not reported in source
ob/ob and lean mice
Comparator
Vehicle (0.9 % NaCl)
Outcome group
Lipids · Metabolic and weight
Studied dose
1 mg.g body wt(-1).day(-1) · subcutaneous · 1 weekAs given in this study (mouse).
Source sentences
Summary
After 1 week of daily injections, 5-aminoimidazole-4-carboxamide ribonucleoside treatment corrected hyperglycaemia, improved glucose tolerance, and increased GLUT4 and hexokinase II protein expression in skeletal muscle, but had deleterious effects on plasma non-esterified fatty acids and triglycerides.
1 context sentence(design, population, supporting numbers)
Summary · context
Lean and ob/ob mice were given 5-aminoimidazole-4-carboxamide ribonucleoside (1 mg.g body wt(-1).day(-1) s.c) or 0.9 % NaCl (vehicle) for 1-7 days.
Report a problemFND-1184522407
08AnimalAnimal study (in vivo)Efficacy outcome
In fasted and fed ob/ob mice, AICAR increased liver glycogen.
In plain wordsIn fasted and fed ob/ob mice, AICAR increased stored liver sugar compared with vehicle.
Peptide
AICAR (acadesine)
Outcome
IncreaseLiver glycogen
Study
mousen: not reported in source
ob/ob and lean mice
Comparator
Vehicle (0.9 % NaCl)
Outcome group
Glycemic control · Metabolic and weight
Studied dose
1 mg.g body wt(-1).day(-1) · subcutaneous · 1-7 daysAs given in this study (mouse).
Source sentences
Summary
Treatment with 5-aminoimidazole-4-carboxamide ribonucleoside increased liver glycogen in fasted and fed ob/ob mice and muscle glycogen in fasted, but not fed ob/ob and lean mice.
1 context sentence(design, population, supporting numbers)
Summary · context
Lean and ob/ob mice were given 5-aminoimidazole-4-carboxamide ribonucleoside (1 mg.g body wt(-1).day(-1) s.c) or 0.9 % NaCl (vehicle) for 1-7 days.
Report a problemFND-1184522408
09AnimalAnimal study (in vivo)Efficacy outcome
In mice, AICAR increased muscle glycogen in fasted mice but not fed ob/ob and lean mice.
In plain wordsIn mice, AICAR increased muscle glycogen during fasting, but not after feeding, compared with vehicle.
Peptide
AICAR (acadesine)
Outcome
MixedMuscle glycogen
Study
mousen: not reported in source
ob/ob and lean mice
Comparator
Vehicle (0.9 % NaCl)
Outcome group
Glycemic control · Metabolic and weight
Studied dose
1 mg.g body wt(-1).day(-1) · subcutaneous · 1-7 daysAs given in this study (mouse).
Source sentences
Summary
Treatment with 5-aminoimidazole-4-carboxamide ribonucleoside increased liver glycogen in fasted and fed ob/ob mice and muscle glycogen in fasted, but not fed ob/ob and lean mice.
1 context sentence(design, population, supporting numbers)
Summary · context
Lean and ob/ob mice were given 5-aminoimidazole-4-carboxamide ribonucleoside (1 mg.g body wt(-1).day(-1) s.c) or 0.9 % NaCl (vehicle) for 1-7 days.
Report a problemFND-1184522409
10AnimalAnimal study (in vivo)Mechanism
In ob/ob mice, AICAR did not correct defective insulin-stimulated skeletal muscle phosphatidylinositol 3-kinase.
In plain wordsIn ob/ob mice, AICAR did not correct defective muscle enzyme responses to insulin compared with vehicle.
Peptide
AICAR (acadesine)
Outcome
No significant changeInsulin-stimulated phosphatidylinositol 3-kinase
Study
mousen: not reported in source
ob/ob and lean mice
Comparator
Vehicle (0.9 % NaCl)
Outcome group
Glycemic control · Metabolic and weight
Studied dose
1 mg.g body wt(-1).day(-1) · subcutaneous · 1-7 daysAs given in this study (mouse).
Source sentences
Summary
Defects in insulin-stimulated phosphatidylinositol 3-kinase and glucose transport in skeletal muscle from ob/ob mice were not corrected by 5-aminoimidazole-4-carboxamide ribonucleoside treatment.
1 context sentence(design, population, supporting numbers)
Summary · context
Lean and ob/ob mice were given 5-aminoimidazole-4-carboxamide ribonucleoside (1 mg.g body wt(-1).day(-1) s.c) or 0.9 % NaCl (vehicle) for 1-7 days.
Report a problemFND-1184522410
11AnimalAnimal study (in vivo)Efficacy outcome
In ob/ob mice, AICAR did not correct defective insulin-stimulated skeletal muscle glucose transport.
In plain wordsIn ob/ob mice, AICAR did not correct defective insulin-stimulated muscle sugar transport compared with vehicle.
Peptide
AICAR (acadesine)
Outcome
No significant changeInsulin-stimulated glucose transport
Study
mousen: not reported in source
ob/ob and lean mice
Comparator
Vehicle (0.9 % NaCl)
Outcome group
Glycemic control · Metabolic and weight
Studied dose
1 mg.g body wt(-1).day(-1) · subcutaneous · 1-7 daysAs given in this study (mouse).
Source sentences
Summary
Defects in insulin-stimulated phosphatidylinositol 3-kinase and glucose transport in skeletal muscle from ob/ob mice were not corrected by 5-aminoimidazole-4-carboxamide ribonucleoside treatment.
1 context sentence(design, population, supporting numbers)
Summary · context
Lean and ob/ob mice were given 5-aminoimidazole-4-carboxamide ribonucleoside (1 mg.g body wt(-1).day(-1) s.c) or 0.9 % NaCl (vehicle) for 1-7 days.
Report a problemFND-1184522411
12LabEx vivo tissueEfficacy outcome
In isolated ob/ob mouse muscle, the AICAR-stimulated glucose transport response was normal.
In plain wordsIn lab tests, muscle from mice with diabetes showed a normal sugar transport response to AICAR.
Peptide
AICAR (acadesine)
Outcome
No significant changeAICAR-stimulated glucose transport
Study
mousen: not reported in source
isolated ob/ob mouse muscle
Outcome group
Glycemic control · Metabolic and weight
Studied dose
Dose not stated
Source sentences
Summary
While ex vivo insulin-stimulated glucose transport was reduced in isolated muscle from ob/ob mice, the 5-aminoimidazole-4-carboxamide ribonucleoside stimulated response was normal.
1 context sentence(design, population, supporting numbers)
Summary · context
Lean and ob/ob mice were given 5-aminoimidazole-4-carboxamide ribonucleoside (1 mg.g body wt(-1).day(-1) s.c) or 0.9 % NaCl (vehicle) for 1-7 days.
Report a problemFND-1184522412

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
21 Oct 2026, 15:58 UTC
Study results updated
Version 1
21 Oct 2026, 12:50 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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