Skip to content

Study · Measured the body's own peptide · 2002

4 results

Ciliary neurotrophic factor increases the survival of magnocellular vasopressin and oxytocin neurons in rat supraoptic nucleus in organotypic cultures.

Rusnak M, House SB, Arima H, Gainer H

Microscopy research and technique1 Jan 2002Cited by 23 (Europe PMC)

PMID11810713 (opens in a new tab)DOI10.1002/jemt.10015 (opens in a new tab)PepBankPUB-11810713
Publisher pagePubMedAsk about this study
Jump to 4 results

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

No result from this study comes from a test of the peptide.

Natural levels measured4

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

  1. 01LabEndogenous levelEx vivo tissueMechanism

    In organotypic cultures of rat supraoptic nucleus, CNTF increased the survival of oxytocin magnocellular neurons 3-fold.

    In plain wordsIn rat brain tissue cultures, CNTF raised survival of the cells that make the body's own oxytocin about 3-fold.

    Peptide
    Oxytocin
    Outcome
    IncreaseSurvival of oxytocin magnocellular neurons, rat supraoptic nucleus
    Study

    ratn: not reported in source

    Organotypic cultures of the supraoptic nucleus
    Outcome group
    Neuroprotection · Nervous system and cognition

    Measurements

    Survival increase of OT-MCNs
    3 fold
    rat SON, CNTF 10 ng/ml

    Source sentences

    Summary
    CNTF (10 ng/ml) in the culture media increased the survival of VP-MCNs by 6-fold and OT-MCNs by 3-fold.
    1 context sentence
    Summary · context
    We examined the effects of CNTF on the survival of these neurons in rat and mouse SONs.

    This result measures the body's own Oxytocin. Nobody was given the peptide. It is not evidence about taking it.

  2. 02LabEndogenous levelEx vivo tissueMechanism

    In organotypic cultures of mouse supraoptic nucleus, oxytocin magnocellular neurons survived well under standard conditions and CNTF had no further effect.

    In plain wordsIn mouse brain tissue cultures, cells that make the body's own oxytocin survived well, and CNTF made no further difference.

    Peptide
    Oxytocin
    Outcome
    No significant changeSurvival of oxytocin magnocellular neurons, mouse supraoptic nucleus
    Study

    mousen: not reported in source

    Organotypic cultures of the supraoptic nucleus
    Outcome group
    Neuroprotection · Nervous system and cognition

    Source sentences

    Summary
    In the mouse, both OT- and VP-MCNs survive very well in organotypic cultures under standard culture conditions and the addition of CNTF had no further effect.
    1 context sentence
    Summary · context
    We examined the effects of CNTF on the survival of these neurons in rat and mouse SONs.

    This result measures the body's own Oxytocin. Nobody was given the peptide. It is not evidence about taking it.

  3. 03LabEndogenous levelEx vivo tissueMechanism

    In rat organotypic cultures, CNTF increased oxytocin mRNA in the paraventricular and supraoptic nuclei.

    In plain wordsIn rat brain tissue cultures, CNTF raised the amount of messenger RNA for the body's own oxytocin.

    Peptide
    Oxytocin
    Outcome
    IncreaseOxytocin mRNA level, rat paraventricular and supraoptic nuclei
    Study

    ratn: not reported in source

    Organotypic cultures of the supraoptic nucleus
    Outcome group
    Neuroprotection · Nervous system and cognition

    Source sentences

    Summary
    Consistent with these results, in situ hybridization showed substantially higher levels of VP- and OT-mRNA in rat PVNs and SONs in the presence of CNTF, but produced no changes in these nuclei in the mouse.
    1 context sentence
    Summary · context
    We examined the effects of CNTF on the survival of these neurons in rat and mouse SONs.

    This result measures the body's own Oxytocin. Nobody was given the peptide. It is not evidence about taking it.

  4. 04LabEndogenous levelEx vivo tissueMechanism

    In mouse organotypic cultures, CNTF produced no change in oxytocin mRNA in the paraventricular and supraoptic nuclei.

    In plain wordsIn mouse brain tissue cultures, CNTF did not change the amount of messenger RNA for the body's own oxytocin.

    Peptide
    Oxytocin
    Outcome
    No significant changeOxytocin mRNA level, mouse paraventricular and supraoptic nuclei
    Study

    mousen: not reported in source

    Organotypic cultures of the supraoptic nucleus
    Outcome group
    Neuroprotection · Nervous system and cognition

    Source sentences

    Summary
    Consistent with these results, in situ hybridization showed substantially higher levels of VP- and OT-mRNA in rat PVNs and SONs in the presence of CNTF, but produced no changes in these nuclei in the mouse.
    1 context sentence
    Summary · context
    We examined the effects of CNTF on the survival of these neurons in rat and mouse SONs.

    This result measures the body's own Oxytocin. Nobody was given the peptide. It is not evidence about taking it.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 20:03 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:53 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

PepBank is a research reference. Talk to a doctor before you use any peptide.