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Study · Animal study (in vivo) · rat · 2001

5 results

[The delta-sleep inducing peptide and its effect on the electroencephalogram and power spectrum density in rats with metaphit-induced epilepsy].

Stanojlovic O, Zivanovic D, Susic V

Srpski arhiv za celokupno lekarstvo1 May 2001

PMID11797457 (opens in a new tab)PepBankPUB-11797457
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

5 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Mechanism

    In rats with metaphit-induced epilepsy, DSIP increased EEG output in the 8 band.

    In plain wordsIn rats with induced seizures, DSIP increased brain electrical activity in one frequency range.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    IncreaseEEG output in the 8 band
    Study

    ratn: not reported in source

    metaphit-induced audiogenic epilepsy
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    1 mg/kgAs given in this study (rat).

    Source sentences

    Summary
    DSIP acted increasing the EEG output in the 8 range
    2 context sentences
    Summary · context
    Adult, 2-month-old male Wistar rats (170-200 g) were used.
    Summary · context
    Control, saline-injected (n = 6); 2. metaphit administered (10 mg/kg; n = 12); 3. metaphit + DSIP (1 mg/kg), (n = 14) group, DSIP administered after 8th to investigate blocking effect on fully developed metaphit seizure.
  2. 02AnimalAnimal study (in vivo)Mechanism

    In rats with metaphit-induced epilepsy, DSIP significantly elevated the mean power spectra at all checked experimental points.

    In plain wordsIn rats with induced seizures, DSIP raised the mean strength of brain electrical activity.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    IncreaseMean EEG power spectra
    Study

    ratn: not reported in source

    metaphit-induced audiogenic epilepsy
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    1 mg/kgAs given in this study (rat).

    Source sentences

    Summary
    and significantly elevated the mean power spectra in all checked experimental points.
    2 context sentences
    Summary · context
    Adult, 2-month-old male Wistar rats (170-200 g) were used.
    Summary · context
    Control, saline-injected (n = 6); 2. metaphit administered (10 mg/kg; n = 12); 3. metaphit + DSIP (1 mg/kg), (n = 14) group, DSIP administered after 8th to investigate blocking effect on fully developed metaphit seizure.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In rats with metaphit-induced seizures, DSIP decreased the incidence of the convulsive component.

    In plain wordsIn rats with induced seizures, DSIP lowered how often convulsions occurred.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    DecreaseIncidence of convulsive component
    Study

    ratn: not reported in source

    metaphit-induced audiogenic epilepsy
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    1 mg/kgAs given in this study (rat).

    Source sentences

    Summary
    Besides, DSIP decreased the incidence and duration of convulsive component, as well as mean seizure grade in metaphit-induced seizures.
    2 context sentences
    Summary · context
    Adult, 2-month-old male Wistar rats (170-200 g) were used.
    Summary · context
    Control, saline-injected (n = 6); 2. metaphit administered (10 mg/kg; n = 12); 3. metaphit + DSIP (1 mg/kg), (n = 14) group, DSIP administered after 8th to investigate blocking effect on fully developed metaphit seizure.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In rats with metaphit-induced seizures, DSIP decreased the duration of the convulsive component.

    In plain wordsIn rats with induced seizures, DSIP shortened convulsions.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    DecreaseDuration of convulsive component
    Study

    ratn: not reported in source

    metaphit-induced audiogenic epilepsy
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    1 mg/kgAs given in this study (rat).

    Source sentences

    Summary
    Besides, DSIP decreased the incidence and duration of convulsive component, as well as mean seizure grade in metaphit-induced seizures.
    2 context sentences
    Summary · context
    Adult, 2-month-old male Wistar rats (170-200 g) were used.
    Summary · context
    Control, saline-injected (n = 6); 2. metaphit administered (10 mg/kg; n = 12); 3. metaphit + DSIP (1 mg/kg), (n = 14) group, DSIP administered after 8th to investigate blocking effect on fully developed metaphit seizure.
  5. 05AnimalAnimal study (in vivo)Efficacy outcome

    In rats with metaphit-induced seizures, DSIP decreased the mean seizure grade.

    In plain wordsIn rats with induced seizures, DSIP lowered seizure severity.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    DecreaseMean seizure grade
    Study

    ratn: not reported in source

    metaphit-induced audiogenic epilepsy
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    1 mg/kgAs given in this study (rat).

    Source sentences

    Summary
    Besides, DSIP decreased the incidence and duration of convulsive component, as well as mean seizure grade in metaphit-induced seizures.
    2 context sentences
    Summary · context
    Adult, 2-month-old male Wistar rats (170-200 g) were used.
    Summary · context
    Control, saline-injected (n = 6); 2. metaphit administered (10 mg/kg; n = 12); 3. metaphit + DSIP (1 mg/kg), (n = 14) group, DSIP administered after 8th to investigate blocking effect on fully developed metaphit seizure.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    12 Oct 2026, 17:28 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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