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Study · Animal study (in vivo) · rat · 2002

4 results

Selective anabolic effects of muteins of mid-region PTH fragments on skeletal tissues of prepubertal rats.

Kim TY, Vargas V, Mayer H, Somjen D, Kaye AM

Bone1 Jan 2002Cited by 10 (Europe PMC)

PMID11792568 (opens in a new tab)DOI10.1016/s8756-3282(01)00664-0 (opens in a new tab)PepBankPUB-11792568
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In prepubertal rats, native PTH increased creatine kinase specific activity in tibial diaphysis.

    In plain wordsIn rats, native PTH increased creatine kinase activity in tibial shaft tissue.

    Peptide
    PTH 1-84 (parathyroid hormone)
    Outcome
    IncreaseTibial diaphyseal creatine kinase activity
    Study

    ratn: not reported in source

    17-day-old female Wistar-derived rats
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    200 ng/day · injectionAs given in this study (rat).

    Source sentences

    Summary
    At the low concentration of 200 ng/day of PTH (1-84), or the molar equivalent of the fragment, and 50 ng E(2), all the hormones increased significantly the specific activity of creatine kinase (CK; a marker of skeletal cell proliferation) in tibial diaphysis and epiphysis,
    1 context sentence
    Summary · context
    The hormones, at concentrations spanning a 100-fold range, were given by 14 injections (6/week, excluding Saturday), to 17-day-old female Wistar-derived rats.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In prepubertal rats, native PTH increased creatine kinase specific activity in tibial epiphysis.

    In plain wordsIn rats, native PTH increased creatine kinase activity in tibial end tissue.

    Peptide
    PTH 1-84 (parathyroid hormone)
    Outcome
    IncreaseTibial epiphyseal creatine kinase activity
    Study

    ratn: not reported in source

    17-day-old female Wistar-derived rats
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    200 ng/day · injectionAs given in this study (rat).

    Source sentences

    Summary
    At the low concentration of 200 ng/day of PTH (1-84), or the molar equivalent of the fragment, and 50 ng E(2), all the hormones increased significantly the specific activity of creatine kinase (CK; a marker of skeletal cell proliferation) in tibial diaphysis and epiphysis,
    1 context sentence
    Summary · context
    The hormones, at concentrations spanning a 100-fold range, were given by 14 injections (6/week, excluding Saturday), to 17-day-old female Wistar-derived rats.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In prepubertal rats, native PTH increased cortical bone width in the humeral diaphysis.

    In plain wordsIn rats, native PTH increased cortical bone width in the humeral shaft.

    Peptide
    PTH 1-84 (parathyroid hormone)
    Outcome
    IncreaseHumeral cortical width
    Study

    ratn: not reported in source

    17-day-old female Wistar-derived rats
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    200 ng/day · injectionAs given in this study (rat).

    Source sentences

    Summary
    the width of the cortical bone in the humeral diaphysis,
    2 context sentences
    Summary · context
    At the low concentration of 200 ng/day of PTH (1-84), or the molar equivalent of the fragment, and 50 ng E(2), all the hormones increased significantly
    Summary · context
    The hormones, at concentrations spanning a 100-fold range, were given by 14 injections (6/week, excluding Saturday), to 17-day-old female Wistar-derived rats.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In prepubertal rats, native PTH increased the number of cells in the proliferating zone of the humeral epiphyseal growth plate.

    In plain wordsIn rats, native PTH increased cell numbers in the proliferating zone of the humeral growth plate.

    Peptide
    PTH 1-84 (parathyroid hormone)
    Outcome
    IncreaseGrowth plate proliferating cells
    Study

    ratn: not reported in source

    17-day-old female Wistar-derived rats
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    200 ng/day · injectionAs given in this study (rat).

    Source sentences

    Summary
    and the number of cells in the proliferating zone of the humeral epiphyseal growth plate.
    2 context sentences
    Summary · context
    At the low concentration of 200 ng/day of PTH (1-84), or the molar equivalent of the fragment, and 50 ng E(2), all the hormones increased significantly
    Summary · context
    The hormones, at concentrations spanning a 100-fold range, were given by 14 injections (6/week, excluding Saturday), to 17-day-old female Wistar-derived rats.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    28 Oct 2026, 02:03 UTC

    Study results updated

  2. Version 1

    27 Oct 2026, 16:37 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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