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Study · Animal study (in vivo) · mouse · 2002

3 results

Thymosin alpha1 accelerates restoration of T cell-mediated neutralizing antibody response in immunocompromised hosts.

Li CL, Zhang T, Saibara T, Nemoto Y, Ono M, Akisawa N, Iwasaki S, Maeda T, Onishi S

International immunopharmacology1 Jan 2002Cited by 20 (Europe PMC)

PMID11789668 (opens in a new tab)DOI10.1016/s1567-5769(01)00136-9 (opens in a new tab)PepBankPUB-11789668
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In mice with 5-fluorouracil-suppressed immunity, synthetic thymosin alpha1 restored T cell-mediated antibody production against HBsAg, with activity at 30 microg/kg.

    In plain wordsIn mice with suppressed immunity, thymosin alpha1 restored antibody production against the hepatitis B surface antigen at a low dose.

    Peptide
    Thymosin alpha-1
    Outcome
    IncreaseT cell-mediated neutralizing antibody production against HBsAg
    Study

    mousen: not reported in source

    Mice with 5-fluorouracil-suppressed antibody production
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    30 microg/kgAs given in this study (mouse).

    Source sentences

    Summary
    We proved that chemically synthesized thymosin alpha1 restored the T cell-mediated antibody production following its suppression in mice by 5-fluorouracil (5-FU), and found that thymosin alpha1 showed activity at a low dose of 30 microg/kg.
  2. 02AnimalAnimal study (in vivo)Mechanism

    In mice with 5-fluorouracil-suppressed immunity, thymosin alpha1 at 30 microg/kg accelerated the replenishment and maturation of thymocytes.

    In plain wordsIn mice with suppressed immunity, thymosin alpha1 sped up the recovery and maturation of thymus immune cells.

    Peptide
    Thymosin alpha-1
    Outcome
    IncreaseThymocyte replenishment and maturation
    Study

    mousen: not reported in source

    Mice with 5-fluorouracil-suppressed antibody production
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    30 microg/kgAs given in this study (mouse).

    Source sentences

    Summary
    Further studies utilizing the flowcytometric analysis showed that thymosin alpha1 at this dose accelerated the replenishment and maturation of thymocytes
  3. 03AnimalAnimal study (in vivo)Mechanism

    In mice with 5-fluorouracil-suppressed immunity, thymosin alpha1 at 30 microg/kg did not change Smoothened expression in CD4-CD8- thymocytes.

    In plain wordsIn mice with suppressed immunity, thymosin alpha1 did not change the level of the Smoothened signaling protein in young thymus cells.

    Peptide
    Thymosin alpha-1
    Outcome
    No significant changeSmoothened (Smo) expression in CD4-CD8- thymocytes
    Study

    mousen: not reported in source

    Mice with 5-fluorouracil-suppressed antibody production
    Outcome group
    Receptor activity and mechanism · Immune and inflammation
    Studied dose
    30 microg/kgAs given in this study (mouse).

    Source sentences

    Summary
    the expression of Smoothened (Smo) of the Hedgehog (Hh)-signaling in CD4-CD8- thymocytes, the potent negative regulator of proliferative responses, was not affected.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    10 Oct 2026, 08:55 UTC

    Study results updated

  2. Version 2

    9 Oct 2026, 03:03 UTC

    Study data updated · source update from Europe PMC

  3. Version 1

    9 Oct 2026, 03:02 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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