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Study · Animal study (in vivo) · rat · 2001

3 results

Proline-containing dipeptide GVS-111 retains nootropic activity after oral administration.

Ostrovskaya RU, Mirsoev TK, Romanova GA, Gudasheva TA, Kravchenko EV, Trofimov CC, Voronina TA, Seredenin SB

Bulletin of experimental biology and medicine1 Oct 2001Cited by 2 (Europe PMC)

PMID11782792 (opens in a new tab)DOI10.1023/a:1013663126973 (opens in a new tab)PepBankPUB-11782792
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In rats trained in passive avoidance, orally administered GVS-111 retained antiamnesic activity.

    In plain wordsIn rats, oral GVS-111 retained activity against memory impairment.

    Peptide
    Noopept (omberacetam)
    Outcome
    IncreaseAntiamnesic activity after oral administration
    Study

    ratn: not reported in source

    passive avoidance task
    Outcome group
    Cognition and memory · Nervous system and cognition
    Studied dose
    0.5-10 mg/kg · oralAs given in this study (rat).

    Source sentences

    Summary
    Experiments on rats trained passive avoidance task showed that N-phenyl-acetyl-L-prolyl-glycyl ethyl ester, peptide analog of piracetam (GVS-111, Noopept) after oral administration retained antiamnesic activity previously observed after its parenteral administration.
    1 context sentence
    Summary · context
    Effective doses were 0.5-10 mg/kg.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In rats, a single GVS-111 administration stimulated one-session active avoidance learning.

    In plain wordsIn rats, a single GVS-111 administration improved active avoidance learning in one session.

    Peptide
    Noopept (omberacetam)
    Outcome
    IncreaseOne-session learning
    Study

    ratn: not reported in source

    active avoidance, massive one-session learning schedule
    Outcome group
    Cognition and memory · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Experiments on a specially-developed model of active avoidance (massive one-session learning schedule) showed that GVS-111 stimulated one-session learning after single administration, while after repeated administration it increased the number of successful learners among those animals who failed af…
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In rats that failed initial training, repeated GVS-111 administration increased the number of successful learners.

    In plain wordsIn rats that failed initial training, repeated GVS-111 administration increased the number that learned successfully.

    Peptide
    Noopept (omberacetam)
    Outcome
    IncreaseSuccessful learners after repeated administration
    Study

    ratn: not reported in source

    active avoidance, massive one-session learning schedule, initial training failures
    Outcome group
    Cognition and memory · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Experiments on a specially-developed model of active avoidance (massive one-session learning schedule) showed that GVS-111 stimulated one-session learning after single administration, while after repeated administration it increased the number of successful learners among those animals who failed af…

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 12:50 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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