In cell-free medium from fetal rat lung fibroblasts, des(1‑3)IGF-I enhanced IGFBP-4 proteolysis, less strongly than IGF-I and IGF-II.
In plain wordsIn lab tests, des(1‑3)IGF-I increased IGFBP-4 breakdown, less strongly than IGF-I and IGF-II.
- Peptide
- IGF-1 DES (des(1-3)IGF-I)
- Outcome
- IncreaseIGFBP-4 proteolysis
- Study
ratn: not reported in source
Cell-free conditioned medium from fetal lung fibroblasts- Comparator
- Conditioned medium without added IGF
- Outcome group
- Receptor activity and mechanism · Respiratory
- Studied dose
- Dose not stated
Source sentences
IGFBP-4 proteolysis was inhibited by EDTA and 1,10-phenanthroline and was accentuated by the addition of IGF-I and IGF-II and, to a lesser extent, by des(1-3)IGF-I.
1 context sentence(design, population, supporting numbers)
Proteolysis of IGFBP-4 was detected in aliquots of cell-free CM from cells exposed to SFM for 48 hours.