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Study · Animal study (in vivo) · rat · 2001

2 results

Expression of the c-fos gene during emotional stress in rats: the clocking effect of delta sleep-inducing peptide.

Sudakov KV, Umryukhin PE, Koplik EV, Anokhin KV

Neuroscience and behavioral physiology1 Nov 2001Cited by 6 (Europe PMC)

PMID11766904 (opens in a new tab)DOI10.1023/a:1012381413726 (opens in a new tab)PepBankPUB-11766904
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

2 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Mechanism

    In rats under emotional stress, intraperitoneal DSIP at 60 nmol/kg weakened stress-induced expression of the c-fos gene.

    In plain wordsIn rats under stress, DSIP weakened the stress-driven rise in c-fos gene activity in the brain.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    DecreaseStress-induced c-fos expression
    Study

    ratn: not reported in source

    Outcome group
    Anxiety and mood · Mental health and mood
    Studied dose
    60 nmol/kg · intraperitonealAs given in this study (rat).

    Source sentences

    Summary
    I.p. doses of delta sleep-inducing peptide (DSIP) (60 nmol/kg) weakened the stress-induced expression of the c-fos gene.
  2. 02AnimalAnimal study (in vivo)Mechanism

    In rats predisposed to emotional stress, preliminary DSIP injections decreased stress-induced c-fos expression in the paraventricular hypothalamus and the medial and lateral septum.

    In plain wordsIn stress-predisposed rats, DSIP given beforehand lowered c-fos gene activity in three stress-related brain areas.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    DecreaseStress-induced c-fos expression in paraventricular hypothalamus and septum, predisposed rats
    Study

    ratn: not reported in source

    Outcome group
    Anxiety and mood · Mental health and mood
    Studied dose
    Dose not stated · intraperitonealAs given in this study (rat).

    Source sentences

    Summary
    This effect was more apparent in animals predisposed to emotional stress, in which preliminary injections decreased stress-induced c-fos expression in the paraventricular hypothalamus and the medial and lateral parts of the septum.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    10 Oct 2026, 08:55 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

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