Gastric antisecretory and antiulcer activity of oxytocin in rats and guinea pigs.

Asad M, Shewade DG, Koumaravelou K, Abraham BK, Vasu S, Ramaswamy S

Life sciences1 Nov 2001Cited by 22 (Europe PMC)

PMID11764003DOI10.1016/s0024-3205(01)01376-5PepBankPUB-11764003

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study9

9 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Efficacy outcome
In pylorus-ligated rats, oxytocin showed significant antisecretory activity on gastric acid secretion.
In plain wordsIn rats, oxytocin reduced stomach acid secretion in a model of ligated stomach outlet.
Peptide
Oxytocin
Outcome
DecreaseGastric acid secretion in pylorus-ligated rats
Study
ratn: not reported in source
pylorus ligation
Outcome group
Gastrointestinal protection · Gastrointestinal
Studied dose
1 mg/kg · subcutaneousAs given in this study (rat).
Source sentences
Summary
Oxytocin showed significant antisecretory and antiulcer activity in pylorus ligated rats.
1 context sentence(design, population, supporting numbers)
Summary · context
The effect of oxytocin (1 mg/kg s.c) on gastric acid secretion and on different experimentally induced gastric and duodenal ulcers was studied.
Report a problemFND-1176400301
02AnimalAnimal study (in vivo)Efficacy outcome
In pylorus-ligated rats, oxytocin showed significant antiulcer activity.
In plain wordsIn rats, oxytocin protected against stomach ulcers in a model of ligated stomach outlet.
Peptide
Oxytocin
Outcome
DecreaseUlcer index in pylorus-ligated rats
Study
ratn: not reported in source
pylorus ligation
Outcome group
Gastrointestinal protection · Gastrointestinal
Studied dose
1 mg/kg · subcutaneousAs given in this study (rat).
Source sentences
Summary
Oxytocin showed significant antisecretory and antiulcer activity in pylorus ligated rats.
1 context sentence(design, population, supporting numbers)
Summary · context
The effect of oxytocin (1 mg/kg s.c) on gastric acid secretion and on different experimentally induced gastric and duodenal ulcers was studied.
Report a problemFND-1176400302
03AnimalAnimal study (in vivo)Efficacy outcome
In guinea pigs with histamine-induced gastric ulcers, oxytocin reduced the ulcer index.
In plain wordsIn guinea pigs, oxytocin reduced stomach ulcer damage caused by histamine.
Peptide
Oxytocin
Outcome
DecreaseUlcer index in histamine-induced gastric ulcers
Study
guinea pign: not reported in source
histamine-induced gastric ulcer
Outcome group
Gastrointestinal protection · Gastrointestinal
Studied dose
1 mg/kg · subcutaneousAs given in this study (guinea pig).
Source sentences
Summary
Similarly oxytocin reduced the ulcer index in histamine induced gastric ulcers in guinea pigs and cysteamine induced duodenal ulcers in rats.
1 context sentence(design, population, supporting numbers)
Summary · context
The effect of oxytocin (1 mg/kg s.c) on gastric acid secretion and on different experimentally induced gastric and duodenal ulcers was studied.
Report a problemFND-1176400303
04AnimalAnimal study (in vivo)Efficacy outcome
In rats with cysteamine-induced duodenal ulcers, oxytocin reduced the ulcer index.
In plain wordsIn rats, oxytocin reduced duodenal ulcer damage caused by cysteamine.
Peptide
Oxytocin
Outcome
DecreaseUlcer index in cysteamine-induced duodenal ulcers
Study
ratn: not reported in source
cysteamine-induced duodenal ulcer
Outcome group
Gastrointestinal protection · Gastrointestinal
Studied dose
1 mg/kg · subcutaneousAs given in this study (rat).
Source sentences
Summary
oxytocin reduced the ulcer index in histamine induced gastric ulcers in guinea pigs and cysteamine induced duodenal ulcers in rats
1 context sentence(design, population, supporting numbers)
Summary · context
The effect of oxytocin (1 mg/kg s.c) on gastric acid secretion and on different experimentally induced gastric and duodenal ulcers was studied.
Report a problemFND-1176400304
05AnimalAnimal study (in vivo)Efficacy outcome
In the ethanol-induced ulcer model, oxytocin showed no gastric cytoprotective effect.
In plain wordsIn rats or guinea pigs, oxytocin did not protect the stomach lining in an ethanol ulcer model.
Peptide
Oxytocin
Outcome
No significant changeCytoprotection in ethanol-induced ulcers
Study
n: not reported in source
ethanol-induced gastric ulcer
Outcome group
Gastrointestinal protection · Gastrointestinal
Studied dose
1 mg/kg · subcutaneousAs given in this study.
Source sentences
Summary
it did not show any gastric cytoprotective effect in ethanol and indomethacin induced ulcer models but ranitidine showed protection (p<0.05) in later model.
1 context sentence(design, population, supporting numbers)
Summary · context
The effect of oxytocin (1 mg/kg s.c) on gastric acid secretion and on different experimentally induced gastric and duodenal ulcers was studied.
Report a problemFND-1176400305
06AnimalAnimal study (in vivo)Efficacy outcome
In the indomethacin-induced ulcer model, oxytocin showed no gastric cytoprotective effect, while ranitidine showed protection (p<0.05).
In plain wordsIn rats or guinea pigs, oxytocin did not protect the stomach lining in an indomethacin ulcer model, while ranitidine did.
Peptide
Oxytocin
Outcome
No significant changeCytoprotection in indomethacin-induced ulcers
Study
n: not reported in source
indomethacin-induced gastric ulcer
Comparator
Ranitidine
Outcome group
Gastrointestinal protection · Gastrointestinal
Studied dose
1 mg/kg · subcutaneousAs given in this study.
Source sentences
Summary
it did not show any gastric cytoprotective effect in ethanol and indomethacin induced ulcer models but ranitidine showed protection (p<0.05) in later model.
1 context sentence(design, population, supporting numbers)
Summary · context
The effect of oxytocin (1 mg/kg s.c) on gastric acid secretion and on different experimentally induced gastric and duodenal ulcers was studied.
Report a problemFND-1176400306
07AnimalAnimal study (in vivo)Efficacy outcome
In rats with acetic acid-induced chronic gastric ulcers, oxytocin enhanced ulcer healing.
In plain wordsIn rats or guinea pigs, oxytocin improved healing of long-lasting stomach ulcers.
Peptide
Oxytocin
Outcome
IncreaseHealing of acetic acid-induced chronic gastric ulcer
Study
n: not reported in source
acetic acid-induced chronic gastric ulcer
Outcome group
Gastrointestinal protection · Gastrointestinal
Studied dose
1 mg/kg · subcutaneousAs given in this study.
Source sentences
Summary
Oxytocin enhanced gastric ulcer healing in acetic acid induced chronic gastric ulcer model.
1 context sentence(design, population, supporting numbers)
Summary · context
The effect of oxytocin (1 mg/kg s.c) on gastric acid secretion and on different experimentally induced gastric and duodenal ulcers was studied.
Report a problemFND-1176400307
08AnimalAnimal study (in vivo)Efficacy outcome
The antiulcer and antisecretory effect of oxytocin was comparable to that of ranitidine but less intense.
In plain wordsIn rats or guinea pigs, oxytocin's effect against ulcers and acid was similar to ranitidine, though weaker.
Peptide
Oxytocin
Outcome
MixedAntiulcer and antisecretory effect versus ranitidine
Study
n: not reported in source
experimentally induced gastric and duodenal ulcer models
Comparator
Ranitidine 50 mg/kg i.p.
Outcome group
Gastrointestinal protection · Gastrointestinal
Studied dose
1 mg/kg · subcutaneousAs given in this study.
Source sentences
Summary
The antiulcer and antisecretory effect was comparable to that of ranitidine (50mg/kg, i.p) though less in intensity.
1 context sentence(design, population, supporting numbers)
Summary · context
The effect of oxytocin (1 mg/kg s.c) on gastric acid secretion and on different experimentally induced gastric and duodenal ulcers was studied.
Report a problemFND-1176400308
09AnimalAnimal study (in vivo)Mechanism
The oxytocin effect on gastric ulcers was reversed by the oxytocin receptor antagonist atosiban, which indicates a role for oxytocin receptors.
In plain wordsIn rats or guinea pigs, a drug that blocks oxytocin receptors reversed the effect of oxytocin.
Peptide
Oxytocin
Outcome
Not applicableReversal of oxytocin effect by atosiban
Study
n: not reported in source
experimentally induced gastric and duodenal ulcer models
Outcome group
Receptor activity and mechanism · Gastrointestinal
Studied dose
1 mg/kg · subcutaneousAs given in this study.
Source sentences
Summary
The reversal of oxytocin effect by atosiban, an oxytocin receptor antagonist indicates a role for oxytocin receptors.
1 context sentence(design, population, supporting numbers)
Summary · context
The effect of oxytocin (1 mg/kg s.c) on gastric acid secretion and on different experimentally induced gastric and duodenal ulcers was studied.
Report a problemFND-1176400309

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
11 Oct 2026, 20:03 UTC
Study results updated
Version 1
9 Oct 2026, 02:50 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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