In cultured keratinocytes and composite keratinocyte grafts, interleukin-1alpha increased mRNA levels of antimicrobial peptides, a group that included LL‑37.
In plain wordsIn lab-grown skin cells, interleukin-1alpha raised the body's own antimicrobial peptide mRNA, a group that included LL‑37.
- Peptide
- LL-37
- Outcome
- IncreaseAntimicrobial peptide mRNA levels (including LL-37) after interleukin-1alpha
- Study
n: not reported in source
cultured composite keratinocyte grafts and keratinocytes on plastic dishes- Outcome group
- Infection and antimicrobial activity · Skin and wound
Source sentences
Treatment with interluekin-1alpha increased mRNA levels of antimicrobial peptides in keratinocytes on plastic dishes and in composite grafts.
1 context sentence(design, population, supporting numbers)
The innate immune response of cultured composite keratinocyte grafts treated with various cytokines was assessed indirectly by measuring the levels of mRNA encoding antimicrobial peptides (human beta defensin-1 and -2, LL-37, and antileukoprotease)
This result measures the body's own LL-37. Nobody was given the peptide. It is not evidence about taking it.