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Study · Animal study (in vivo) · rat · 2002

7 results

Acute central ghrelin and GH secretagogues induce feeding and activate brain appetite centers.

Lawrence CB, Snape AC, Baudoin FM, Luckman SM

Endocrinology1 Jan 2002Cited by 318 (Europe PMC)

PMID11751604 (opens in a new tab)DOI10.1210/endo.143.1.8561 (opens in a new tab)PepBankPUB-11751604
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study7

5 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In rats, intracerebroventricular GHRP‑6 significantly stimulated food intake.

    In plain wordsIn rats, GHRP‑6 injected into the brain increased food intake.

    Peptide
    GHRP-6
    Outcome
    IncreaseFood intake
    Study

    ratsn: not reported in source

    Rats after central secretagogue administration
    Outcome group
    Appetite and food intake · Metabolic and weight
    Studied dose
    Dose not stated · intracerebroventricularAs given in this study (rats).

    Source sentences

    Summary
    Intracerebroventricular (icv) injection of ghrelin or GHRP-6 into rats significantly stimulated food intake and transiently reduced core body temperature.
  2. 02AnimalAnimal study (in vivo)Activity measurement

    In rats, intracerebroventricular GHRP‑6 transiently reduced core temperature.

    In plain wordsIn rats, GHRP‑6 injected into the brain briefly lowered core temperature.

    Peptide
    GHRP-6
    Outcome
    DecreaseCore temperature
    Study

    ratsn: not reported in source

    Rats after central secretagogue administration
    Outcome group
    Body temperature · Whole body
    Studied dose
    Dose not stated · intracerebroventricularAs given in this study (rats).

    Source sentences

    Summary
    Intracerebroventricular (icv) injection of ghrelin or GHRP-6 into rats significantly stimulated food intake and transiently reduced core body temperature.
  3. 03AnimalAnimal study (in vivo)Mechanism

    In rats, central GHRP‑6 activated the arcuate, paraventricular, dorsomedial and lateral hypothalamic regions, nucleus of the tractus solitarius, and area postrema.

    In plain wordsIn rats, GHRP‑6 activated several hypothalamic and brainstem regions.

    Peptide
    GHRP-6
    Outcome
    IncreaseRegional c-Fos activation
    Study

    ratsn: not reported in source

    Rats after central secretagogue administration
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated · intracerebroventricularAs given in this study (rats).

    Source sentences

    Summary
    Using c-Fos immunohistochemistry, we demonstrated that icv ghrelin or GHRP-6 activated several hypothalamic brain regions, including the arcuate nucleus, paraventricular nucleus, dorsomedial nucleus, lateral hypothalamus, and two regions of the brainstem, the nucleus of the tractus solitarius and the area postrema.
    1 context sentence
    Summary · context
    Intracerebroventricular (icv) injection of ghrelin or GHRP-6 into rats significantly stimulated food intake and transiently reduced core body temperature.
  4. 04AnimalAnimal study (in vivo)Mechanism

    In rats, central GHRP‑6 significantly activated orexin-containing lateral hypothalamic neurons.

    In plain wordsIn rats, GHRP‑6 activated orexin-containing neurons in the lateral hypothalamus.

    Peptide
    GHRP-6
    Outcome
    IncreaseOrexin neuron activation
    Study

    ratsn: not reported in source

    Rats after central secretagogue administration
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated · intracerebroventricularAs given in this study (rats).

    Source sentences

    Summary
    Finally, double immunohistochemistry indicated that orexin-containing, but not melanin-concentrating hormone-containing, neurons in the lateral hypothalamus were activated significantly by central administration of GHRP-6.
    1 context sentence
    Summary · context
    Intracerebroventricular (icv) injection of ghrelin or GHRP-6 into rats significantly stimulated food intake and transiently reduced core body temperature.
  5. 05AnimalAnimal study (in vivo)Mechanism

    In rats, central GHRP‑6 did not significantly activate melanin-concentrating hormone-containing lateral hypothalamic neurons.

    In plain wordsIn rats, GHRP‑6 did not significantly activate lateral hypothalamic neurons containing melanin-concentrating hormone.

    Peptide
    GHRP-6
    Outcome
    No significant changeMelanin-concentrating hormone neuron activation
    Study

    ratsn: not reported in source

    Rats after central secretagogue administration
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated · intracerebroventricularAs given in this study (rats).

    Source sentences

    Summary
    Finally, double immunohistochemistry indicated that orexin-containing, but not melanin-concentrating hormone-containing, neurons in the lateral hypothalamus were activated significantly by central administration of GHRP-6.
    1 context sentence
    Summary · context
    Intracerebroventricular (icv) injection of ghrelin or GHRP-6 into rats significantly stimulated food intake and transiently reduced core body temperature.

Studies that did not test the peptide alone2

In this study, GHRP-6 was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking GHRP-6.

  1. 06AnimalNot a test of GHRP-6 aloneAnimal study (in vivo)Mechanism

    In rats, BIBO3304 pretreatment blocked the food intake response to GHRP‑6.

    In plain wordsIn rats, BIBO3304 blocked the increase in food intake after GHRP‑6.

    Peptide
    GHRP-6
    Outcome
    DecreaseY1 antagonist blockade of feeding
    Study

    ratsn: not reported in source

    Rats after central secretagogue administration
    Outcome group
    Appetite and food intake · Metabolic and weight

    Source sentences

    Summary
    The effect of both ghrelin and GHRP-6 on food intake was blocked by preadministration of a Y1 NPY receptor antagonist (BIBO3304).
    1 context sentence
    Summary · context
    Intracerebroventricular (icv) injection of ghrelin or GHRP-6 into rats significantly stimulated food intake and transiently reduced core body temperature.

    In this study, GHRP-6 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHRP-6.

  2. 07AnimalNot a test of GHRP-6 aloneAnimal study (in vivo)Mechanism

    In rats, denying food after GHRP‑6 did not change the pattern or extent of c-Fos activation.

    In plain wordsIn rats, GHRP‑6 caused similar brain activation with and without access to food.

    Peptide
    GHRP-6
    Outcome
    No significant changeFood-independent c-Fos activation
    Study

    ratsn: not reported in source

    Rats after central secretagogue administration
    Comparator
    Animals with access to food
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition

    Source sentences

    Summary
    The cell activation induced by GHRP-6 was independent of food intake, as the same pattern and extent of c-Fos expression were observed in animals that were denied access to food following treatment.
    1 context sentence
    Summary · context
    Intracerebroventricular (icv) injection of ghrelin or GHRP-6 into rats significantly stimulated food intake and transiently reduced core body temperature.

    In this study, GHRP-6 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHRP-6.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:13 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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