Skip to content

Study · Animal study (in vivo) · rabbit · 2001

5 results

Activation of central melanocortin receptors by MT-II increases cavernosal pressure in rabbits by the neuronal release of NO.

Vemulapalli R, Kurowski S, Salisbury B, Parker E, Davis H

British journal of pharmacology1 Dec 2001Cited by 18 (Europe PMC)

PMID11739247 (opens in a new tab)PMCIDPMC1572913 (opens in a new tab)DOI10.1038/sj.bjp.0704437 (opens in a new tab)PepBankPUB-11739247
Source linkPubMedAsk about this study
Jump to 5 results

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

5 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In anaesthetized rabbits, intravenous MT-II caused dose-related increases in cavernosal pressure.

    In plain wordsIn rabbits, MT-II injected into a vein raised pressure in the penile erectile tissue, more at the higher dose.

    Peptide
    Melanotan II
    Outcome
    IncreaseIntracavernosal pressure
    Study

    rabbitn: not reported in source

    anaesthetized rabbits
    Outcome group
    Sexual function · Reproductive and sexual health
    Studied dose
    66 and 133 microg/kg · intravenousAs given in this study (rabbit).

    Source sentences

    Summary
    Intravenous injection of MT-II (66 and 133 microg kg(-1) elicited dose-related increases in cavernosal pressure.
    1 context sentence
    Summary · context
    In the present study, we investigated the mechanisms by which systemic administration of MT-II increases intracavernosal pressure in anaesthetized rabbits.
  2. 02AnimalAnimal study (in vivo)Mechanism

    In anaesthetized rabbits, the MC3/MC4 receptor antagonist SHU 9119 abolished the MT-II-induced rise in cavernosal pressure.

    In plain wordsIn rabbits, blocking MC3 and MC4 receptors with SHU 9119 stopped the pressure rise that MT-II caused.

    Peptide
    Melanotan II
    Outcome
    Not applicableBlockade of MT-II-induced cavernosal pressure rise by SHU 9119
    Study

    rabbitn: not reported in source

    anaesthetized rabbits
    Outcome group
    Receptor activity and mechanism · Reproductive and sexual health
    Studied dose
    Dose not stated

    Source sentences

    Summary
    SHU 9119 (3 microg kg(-1), i.v.), a non-selective antagonist of MC(3) and MC(4) receptors did not significantly affect either cavernosal pressure or systemic blood pressure but abolished the MT-II-induced increases in cavernosal pressure.
    1 context sentence
    Summary · context
    In the present study, we investigated the mechanisms by which systemic administration of MT-II increases intracavernosal pressure in anaesthetized rabbits.
  3. 03AnimalAnimal study (in vivo)Other

    In anaesthetized rabbits, MT-II produced a depressor (blood pressure lowering) response that SHU 9119 inhibited.

    In plain wordsIn rabbits, MT-II lowered blood pressure, and a receptor blocker reduced this effect.

    Peptide
    Melanotan II
    Outcome
    DecreaseSystemic depressor response to MT-II
    Study

    rabbitn: not reported in source

    anaesthetized rabbits
    Outcome group
    Blood pressure · Cardiovascular
    Studied dose
    Dose not stated

    Source sentences

    Summary
    SHU 9119 also inhibited the depressor response produced by MT-II.
    1 context sentence
    Summary · context
    In the present study, we investigated the mechanisms by which systemic administration of MT-II increases intracavernosal pressure in anaesthetized rabbits.
  4. 04AnimalAnimal study (in vivo)Mechanism

    In anaesthetized rabbits, pudendal nerve ablation or L-NAME pretreatment abolished the MT-II-induced increases in intracavernosal pressure.

    In plain wordsIn rabbits, cutting the pudendal nerves or blocking nitric oxide production stopped the pressure rise caused by MT-II.

    Peptide
    Melanotan II
    Outcome
    Not applicableRole of pudendal nerves and nitric oxide synthase in MT-II-induced cavernosal pressure
    Study

    rabbitn: not reported in source

    anaesthetized rabbits
    Outcome group
    Receptor activity and mechanism · Reproductive and sexual health
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Ablation of the pudendal nerves or pretreatment with L-NAME abolished the MT-II-induced increases in intracavernosal pressure in anaesthetized rabbits.
    1 context sentence
    Summary · context
    In the present study, we investigated the mechanisms by which systemic administration of MT-II increases intracavernosal pressure in anaesthetized rabbits.
  5. 05LabEx vivo tissueMechanism

    In rabbit corpus cavernosal strips in vitro, MT-II had no effect on electrical field stimulation-evoked relaxations.

    In plain wordsIn lab tests on rabbit tissue strips, MT-II did not change nerve-stimulated relaxation.

    Peptide
    Melanotan II
    Outcome
    No significant changeElectrical field stimulation-evoked relaxation of cavernosal strips
    Study

    rabbitn: not reported in source

    rabbit corpus cavernosal strips
    Outcome group
    Sexual function · Reproductive and sexual health
    Studied dose
    10 microMAs given in this study (rabbit).

    Source sentences

    Summary
    MT-II (10 microM) had no effect on electrical field stimulation-evoked relaxations of rabbit corpus cavernosal strips in vitro.
    1 context sentence
    Summary · context
    In the present study, we investigated the mechanisms by which systemic administration of MT-II increases intracavernosal pressure in anaesthetized rabbits.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    10 Oct 2026, 09:43 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

PepBank is a research reference. Talk to a doctor before you use any peptide.