Cerebrolysin therapy in Rett syndrome: clinical and EEG mapping study.

Gorbachevskaya N, Bashina V, Gratchev V, Iznak A

Brain & development1 Dec 2001Cited by 17 (Europe PMC)

PMID11738849DOI10.1016/s0387-7604(01)00349-7PepBankPUB-11738849

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study7

7 results from studies that gave the peptide. 7 results from people.

01HumanNon-randomized trialEfficacy outcome
In girls with Rett syndrome, behavioral activity increased after Cerebrolysin treatment.
In plain wordsIn girls with Rett syndrome, behavioral activity increased compared with before Cerebrolysin treatment.
Peptide
Cerebrolysin
Outcome
IncreaseBehavioral activity
Study
n = 9
Comparator
before Cerebrolysin treatment
Outcome group
Cognition and memory · Nervous system and cognition
Studied dose
Dose not stated
Source sentences
Summary
After Cerebrolysin treatment, increases in the behavioral activity, attention level, motor functions, and non-verbal social communication have been shown in Rett syndrome patients.
1 context sentence(design, population, supporting numbers)
Summary · context
The open pilot study was performed on nine Rett syndrome girls (aged from 2 years and 2 months to 7 years and 6 months) at stage 3 of the illness
Report a problemFND-1173884901
02HumanNon-randomized trialEfficacy outcome
In girls with Rett syndrome, attention increased after Cerebrolysin treatment.
In plain wordsIn girls with Rett syndrome, attention increased compared with before Cerebrolysin treatment.
Peptide
Cerebrolysin
Outcome
IncreaseAttention level
Study
n = 9
Comparator
before Cerebrolysin treatment
Outcome group
Cognition and memory · Nervous system and cognition
Studied dose
Dose not stated
Source sentences
Summary
After Cerebrolysin treatment, increases in the behavioral activity, attention level, motor functions, and non-verbal social communication have been shown in Rett syndrome patients.
1 context sentence(design, population, supporting numbers)
Summary · context
The open pilot study was performed on nine Rett syndrome girls (aged from 2 years and 2 months to 7 years and 6 months) at stage 3 of the illness
Report a problemFND-1173884902
03HumanNon-randomized trialEfficacy outcome
In girls with Rett syndrome, motor functions improved after Cerebrolysin treatment.
In plain wordsIn girls with Rett syndrome, movement improved compared with before Cerebrolysin treatment.
Peptide
Cerebrolysin
Outcome
IncreaseMotor functions
Study
n = 9
Comparator
before Cerebrolysin treatment
Outcome group
Exercise and physical function · Nervous system and cognition
Studied dose
Dose not stated
Source sentences
Summary
After Cerebrolysin treatment, increases in the behavioral activity, attention level, motor functions, and non-verbal social communication have been shown in Rett syndrome patients.
1 context sentence(design, population, supporting numbers)
Summary · context
The open pilot study was performed on nine Rett syndrome girls (aged from 2 years and 2 months to 7 years and 6 months) at stage 3 of the illness
Report a problemFND-1173884903
04HumanNon-randomized trialEfficacy outcome
In girls with Rett syndrome, non-verbal social communication increased after Cerebrolysin treatment.
In plain wordsIn girls with Rett syndrome, non-verbal communication increased compared with before Cerebrolysin treatment.
Peptide
Cerebrolysin
Outcome
IncreaseNon-verbal social communication
Study
n = 9
Comparator
before Cerebrolysin treatment
Outcome group
Cognition and memory · Nervous system and cognition
Studied dose
Dose not stated
Source sentences
Summary
After Cerebrolysin treatment, increases in the behavioral activity, attention level, motor functions, and non-verbal social communication have been shown in Rett syndrome patients.
1 context sentence(design, population, supporting numbers)
Summary · context
The open pilot study was performed on nine Rett syndrome girls (aged from 2 years and 2 months to 7 years and 6 months) at stage 3 of the illness
Report a problemFND-1173884904
05HumanNon-randomized trialEfficacy outcome
In girls with Rett syndrome, theta activity decreased across cortical regions after Cerebrolysin treatment.
In plain wordsIn girls with Rett syndrome, theta brain activity decreased compared with before Cerebrolysin treatment.
Peptide
Cerebrolysin
Outcome
DecreaseTheta activity
Study
n = 9
Comparator
before Cerebrolysin treatment
Outcome group
Cognition and memory · Nervous system and cognition
Studied dose
Dose not stated
Source sentences
Summary
EEG changes included: decrease of theta activity over all cortical regions, increase of beta activity in the frequency band 13-15 Hz, and some restoration of the occipital alpha rhythm (in the narrow 8-9 Hz band).
1 context sentence(design, population, supporting numbers)
Summary · context
The open pilot study was performed on nine Rett syndrome girls (aged from 2 years and 2 months to 7 years and 6 months) at stage 3 of the illness
Report a problemFND-1173884906
06HumanNon-randomized trialEfficacy outcome
In girls with Rett syndrome, beta activity increased in the 13-15 Hz band after Cerebrolysin treatment.
In plain wordsIn girls with Rett syndrome, beta brain activity increased compared with before Cerebrolysin treatment.
Peptide
Cerebrolysin
Outcome
IncreaseBeta activity
Study
n = 9
Comparator
before Cerebrolysin treatment
Outcome group
Cognition and memory · Nervous system and cognition
Studied dose
Dose not stated
Measurements
Beta activity frequency band
13 to 15 Hz
after Cerebrolysin treatment
Source sentences
Summary
EEG changes included: decrease of theta activity over all cortical regions, increase of beta activity in the frequency band 13-15 Hz, and some restoration of the occipital alpha rhythm (in the narrow 8-9 Hz band).
1 context sentence(design, population, supporting numbers)
Summary · context
The open pilot study was performed on nine Rett syndrome girls (aged from 2 years and 2 months to 7 years and 6 months) at stage 3 of the illness
Report a problemFND-1173884907
07HumanNon-randomized trialEfficacy outcome
In girls with Rett syndrome, the occipital alpha rhythm showed some restoration in the 8-9 Hz band after Cerebrolysin treatment.
In plain wordsIn girls with Rett syndrome, the occipital alpha rhythm partly recovered compared with before Cerebrolysin treatment.
Peptide
Cerebrolysin
Outcome
Direction not reportedOccipital alpha rhythm
Study
n = 9
Comparator
before Cerebrolysin treatment
Outcome group
Cognition and memory · Nervous system and cognition
Studied dose
Dose not stated
Measurements
Occipital alpha rhythm frequency band
8 to 9 Hz
after Cerebrolysin treatment
Source sentences
Summary
EEG changes included: decrease of theta activity over all cortical regions, increase of beta activity in the frequency band 13-15 Hz, and some restoration of the occipital alpha rhythm (in the narrow 8-9 Hz band).
1 context sentence(design, population, supporting numbers)
Summary · context
The open pilot study was performed on nine Rett syndrome girls (aged from 2 years and 2 months to 7 years and 6 months) at stage 3 of the illness
Report a problemFND-1173884908

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
14 Oct 2026, 05:02 UTC
Study results updated
Version 1
14 Oct 2026, 01:46 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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MeSH terms

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