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Study · Ex vivo tissue · mouse · 2001

3 results

Vasorelaxant response to isoprenaline, nitric oxide donor, calcitonin gene-related peptide and vasoactive intestinal peptide in aortic rings of adult C57BL/6J mice.

Chan SL, Fiscus RR

European journal of pharmacology1 Nov 2001Cited by 8 (Europe PMC)

PMID11728430 (opens in a new tab)DOI10.1016/s0014-2999(01)01418-2 (opens in a new tab)PepBankPUB-11728430
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabEx vivo tissueActivity measurement

    In mouse aortic rings with healthy endothelium, VIP caused concentration-dependent relaxation of precontracted rings.

    In plain wordsIn mouse aorta rings in the lab, VIP relaxed the blood vessel in a dose-dependent way.

    Peptide
    Vasoactive intestinal peptide (VIP, aviptadil)
    Outcome
    IncreaseVIP-induced relaxation of aortic rings
    Study

    mousen: not reported in source

    Thoracic aortic rings from adult male C57BL/6J mice, precontracted with phenylephrine
    Outcome group
    Vascular function · Cardiovascular
    Studied dose
    Dose not stated

    Measurements

    Maximum relaxation
    65.1%
    VIP, endothelium intact
    -logEC50
    8.29
    VIP, endothelium intact

    Source sentences

    Summary
    Isoprenaline, acetylcholine, calcitonin gene-related peptide (CGRP), vasoactive intestinal peptide (VIP) and sodium nitroprusside all caused concentration-dependent relaxations in aortic rings possessing healthy endothelium and precontracted with phenylephrine.
    2 context sentences
    Summary · context
    Maximum relaxations were 64.9+/-2.6%, 66.8+/-2.9%, 114.3+/-4.6%, 65.1+/-4.2% and 116.2+/-5.1% with -logEC(50) values of 6.76+/-0.14, 7.04+/-0.11, 8.53+/-0.14, 8.29+/-0.26 and 8.10+/-0.20 for isoprenaline, acetylcholine, CGRP, VIP and sodium nitroprusside, respectively.
    Summary · context
    We investigated the vasorelaxant responses on thoracic aortic rings from the adult male C57BL/6J mouse.
  2. 02LabEx vivo tissueActivity measurement

    In mouse aortic rings, responses to VIP were significantly smaller when the endothelium was removed.

    In plain wordsIn mouse aorta rings in the lab, VIP worked less well when the inner vessel lining was removed.

    Peptide
    Vasoactive intestinal peptide (VIP, aviptadil)
    Outcome
    DecreaseVIP relaxation after endothelium removal
    Study

    mousen: not reported in source

    Thoracic aortic rings from adult male C57BL/6J mice, precontracted with phenylephrine
    Comparator
    Endothelium-intact rings
    Outcome group
    Vascular function · Cardiovascular
    Studied dose
    Dose not stated

    Source sentences

    Summary
    There were significantly smaller responses to isoprenaline, acetylcholine, CGRP and VIP when the endothelium was denuded.
    1 context sentence
    Summary · context
    We investigated the vasorelaxant responses on thoracic aortic rings from the adult male C57BL/6J mouse.
  3. 03LabEx vivo tissueActivity measurement

    In mouse aortic rings, the relaxation response to VIP depended completely on the endothelium.

    In plain wordsIn mouse aorta rings in the lab, VIP only relaxed the vessel when the inner lining was present.

    Peptide
    Vasoactive intestinal peptide (VIP, aviptadil)
    Outcome
    DecreaseEndothelium dependence of VIP relaxation
    Study

    mousen: not reported in source

    Thoracic aortic rings from adult male C57BL/6J mice, precontracted with phenylephrine
    Comparator
    Endothelium-intact rings
    Outcome group
    Vascular function · Cardiovascular
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The response to VIP was completely dependent to endothelium.
    1 context sentence
    Summary · context
    We investigated the vasorelaxant responses on thoracic aortic rings from the adult male C57BL/6J mouse.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    12 Oct 2026, 12:58 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 12:41 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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