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Study · Animal study (in vivo) · rat · 2001

4 results

Melanocortin receptor agonist transiently increases oxygen consumption in rats.

Jonsson L, Skarphedinsson JO, Skuladottir GV, Atlason PT, Eiriksdottir VH, Franzson L, Schiöth HB

Neuroreport1 Dec 2001Cited by 23 (Europe PMC)

PMID11726778 (opens in a new tab)DOI10.1097/00001756-200112040-00020 (opens in a new tab)PepBankPUB-11726778
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In rats, continuous intracerebroventricular MTII infusion significantly increased oxygen consumption 2 days after the start.

    In plain wordsIn rats, brain infusion of MTII raised oxygen consumption two days after it started.

    Peptide
    Melanotan II
    Outcome
    IncreaseOxygen consumption on day 2
    Study

    ratn: not reported in source

    rats
    Outcome group
    Body weight · Metabolic and weight
    Studied dose
    Dose not stated · intracerebroventricular infusion · 8 daysAs given in this study (rat).

    Source sentences

    Summary
    We observed significant increase in oxygen consumption 2 days after the start of the MTII infusion.
    1 context sentence
    Summary · context
    Here we investigated the effect of 8 days continuous i.c.v. infusion of either MC receptor agonist MTII or the selective MC4 receptor antagonist HS024 on oxygen consumption, food intake and body weight in rats.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In rats, the MTII-induced increase in oxygen consumption had disappeared by day 4 of the infusion.

    In plain wordsIn rats, the rise in oxygen consumption caused by MTII was gone by day four.

    Peptide
    Melanotan II
    Outcome
    No significant changeOxygen consumption on day 4
    Study

    ratn: not reported in source

    rats
    Outcome group
    Body weight · Metabolic and weight
    Studied dose
    Dose not stated · intracerebroventricular infusion · 8 daysAs given in this study (rat).

    Source sentences

    Summary
    However, this increase had disappeared by day 4 of the study.
    1 context sentence
    Summary · context
    Here we investigated the effect of 8 days continuous i.c.v. infusion of either MC receptor agonist MTII or the selective MC4 receptor antagonist HS024 on oxygen consumption, food intake and body weight in rats.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In rats, MTII substantially decreased food intake during the first days, but feeding then recovered.

    In plain wordsIn rats, MTII cut food intake strongly in the first days, but eating then returned to normal.

    Peptide
    Melanotan II
    Outcome
    MixedFood intake
    Study

    ratn: not reported in source

    rats
    Outcome group
    Appetite and food intake · Metabolic and weight
    Studied dose
    Dose not stated · intracerebroventricular infusion · 8 daysAs given in this study (rat).

    Source sentences

    Summary
    MTII substantially decreased the food intake during the first days, but then the feeding recovered
    1 context sentence
    Summary · context
    Here we investigated the effect of 8 days continuous i.c.v. infusion of either MC receptor agonist MTII or the selective MC4 receptor antagonist HS024 on oxygen consumption, food intake and body weight in rats.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In rats, MTII infusion lowered body weight, which stabilised at a new level, and the weight loss was maintained.

    In plain wordsIn rats, MTII infusion led to weight loss that stayed in place even after food intake recovered.

    Peptide
    Melanotan II
    Outcome
    DecreaseBody weight
    Study

    ratn: not reported in source

    rats
    Outcome group
    Body weight · Metabolic and weight
    Studied dose
    Dose not stated · intracerebroventricular infusion · 8 daysAs given in this study (rat).

    Source sentences

    Summary
    The immediate effect of the MC receptor agonist on both food intake and metabolism was thus transient, even though the weight loss was maintained.
    1 context sentence
    Summary · context
    Here we investigated the effect of 8 days continuous i.c.v. infusion of either MC receptor agonist MTII or the selective MC4 receptor antagonist HS024 on oxygen consumption, food intake and body weight in rats.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    10 Oct 2026, 09:43 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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