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Study · Animal study (in vivo) · rat · 2001

1 result

Chronic blockade of melanocortin receptors alleviates allodynia in rats with neuropathic pain.

Vrinten DH, Adan RA, Groen GJ, Gispen WH

Anesthesia and analgesia1 Dec 2001Cited by 29 (Europe PMC)

PMID11726447 (opens in a new tab)DOI10.1097/00000539-200112000-00052 (opens in a new tab)PepBankPUB-11726447
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study1

1 result from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In rats with chronic constriction injury of the sciatic nerve, chronic MTII infusion increased mechanical allodynia.

    In plain wordsIn rats with nerve injury, long-term MTII infusion made sensitivity to touch worse.

    Peptide
    Melanotan II
    Outcome
    IncreaseMechanical allodynia
    Study

    ratn: not reported in source

    rats with chronic constriction injury of the sciatic nerve
    Outcome group
    Pain · Nervous system and cognition
    Studied dose
    0.1 microg/d · continuous infusion into the cisterna magnaAs given in this study (rat).

    Source sentences

    Summary
    The administration of MTII increased mechanical allodynia
    2 context sentences
    Summary · context
    The effects of the MC receptor antagonist SHU9119 (0.5 microg/d) and agonist MTII (0.1 microg/d) were evaluated in rats with a chronic constriction injury of the sciatic nerve.
    Summary · context
    Drugs were continuously infused into the cisterna magna.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    10 Oct 2026, 09:43 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

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