Skip to content

Study · Animal study (in vivo) · mouse · 2001

9 results

The effects of human GH and its lipolytic fragment (AOD9604) on lipid metabolism following chronic treatment in obese mice and beta(3)-AR knock-out mice.

Heffernan M, Summers RJ, Thorburn A, Ogru E, Gianello R, Jiang WJ, Ng FM

Endocrinology1 Dec 2001Cited by 19 (Europe PMC)

PMID11713213 (opens in a new tab)DOI10.1210/endo.142.12.8522 (opens in a new tab)PepBankPUB-11713213
Publisher pagePubMedAsk about this study
Jump to 9 results

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study9

9 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In obese mice, 14 days of intraperitoneal AOD9604 reduced body weight.

    In plain wordsIn obese mice, AOD9604 given for two weeks lowered body weight.

    Peptide
    AOD-9604
    Outcome
    DecreaseBody weight
    Study

    micen: not reported in source

    obese mice
    Outcome group
    Body weight · Metabolic and weight
    Studied dose
    Dose not stated · intraperitoneal · 14 dAs given in this study (mice).

    Source sentences

    Summary
    Here we describe how hGH and AOD9604 can reduce body weight and body fat in obese mice following 14 d of chronic ip administration.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In obese mice, 14 days of intraperitoneal AOD9604 reduced body fat.

    In plain wordsIn obese mice, AOD9604 given for two weeks lowered body fat.

    Peptide
    AOD-9604
    Outcome
    DecreaseBody fat
    Study

    micen: not reported in source

    obese mice
    Outcome group
    Body composition · Metabolic and weight
    Studied dose
    Dose not stated · intraperitoneal · 14 dAs given in this study (mice).

    Source sentences

    Summary
    Here we describe how hGH and AOD9604 can reduce body weight and body fat in obese mice following 14 d of chronic ip administration.
  3. 03AnimalAnimal study (in vivo)Mechanism

    In obese mice, AOD9604 raised the repressed beta(3)-AR RNA expression to levels comparable with lean mice.

    In plain wordsIn obese mice, AOD9604 raised a fat-cell receptor's gene activity to levels like those in lean mice.

    Peptide
    AOD-9604
    Outcome
    IncreaseBeta(3)-AR RNA expression
    Study

    micen: not reported in source

    obese mice
    Outcome group
    Receptor activity and mechanism · Metabolic and weight
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Importantly, both hGH and AOD9604 are capable of increasing the repressed levels of beta(3)-AR RNA in obese mice to levels comparable with those in lean mice.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In beta(3)-AR knock-out mice, long-term AOD9604 failed to produce the body weight change seen in wild-type mice.

    In plain wordsIn mice lacking the beta(3) receptor, long-term AOD9604 did not change body weight as it did in normal mice.

    Peptide
    AOD-9604
    Outcome
    No significant changeBody weight in knock-out mice
    Study

    micen: not reported in source

    beta(3)-AR knock-out mice
    Outcome group
    Body weight · Metabolic and weight
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The importance of beta(3)-AR was verified when long-term treatment with hGH and AOD9604 in beta(3)-AR knock-out mice failed to produce the change in body weight and increase in lipolysis that was observed in wild-type control mice.
  5. 05AnimalAnimal study (in vivo)Mechanism

    In beta(3)-AR knock-out mice, long-term AOD9604 failed to increase lipolysis as it did in wild-type mice.

    In plain wordsIn mice lacking the beta(3) receptor, long-term AOD9604 did not raise fat breakdown as it did in normal mice.

    Peptide
    AOD-9604
    Outcome
    No significant changeLipolysis in knock-out mice
    Study

    micen: not reported in source

    beta(3)-AR knock-out mice
    Outcome group
    Fat metabolism and adipogenesis · Metabolic and weight
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The importance of beta(3)-AR was verified when long-term treatment with hGH and AOD9604 in beta(3)-AR knock-out mice failed to produce the change in body weight and increase in lipolysis that was observed in wild-type control mice.
  6. 06AnimalAnimal study (in vivo)Mechanism

    In wild-type control mice, long-term AOD9604 increased lipolysis.

    In plain wordsIn normal mice, long-term AOD9604 raised fat breakdown.

    Peptide
    AOD-9604
    Outcome
    IncreaseLipolysis in wild-type mice
    Study

    micen: not reported in source

    wild-type control mice
    Outcome group
    Fat metabolism and adipogenesis · Metabolic and weight
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The importance of beta(3)-AR was verified when long-term treatment with hGH and AOD9604 in beta(3)-AR knock-out mice failed to produce the change in body weight and increase in lipolysis that was observed in wild-type control mice.
  7. 07AnimalAnimal study (in vivo)Mechanism

    In an acute experiment in beta(3)-AR knock-out mice, AOD9604 increased energy expenditure.

    In plain wordsIn mice lacking the beta(3) receptor, AOD9604 raised energy use in a short-term test.

    Peptide
    AOD-9604
    Outcome
    IncreaseEnergy expenditure in acute experiment
    Study

    micen: not reported in source

    beta(3)-AR knock-out mice
    Outcome group
    Fat metabolism and adipogenesis · Metabolic and weight
    Studied dose
    Dose not stated

    Source sentences

    Summary
    However, in an acute experiment, AOD9604 was capable of increasing energy expenditure and fat oxidation in the beta(3)-AR knock-out mice.
  8. 08AnimalAnimal study (in vivo)Mechanism

    In an acute experiment in beta(3)-AR knock-out mice, AOD9604 increased fat oxidation.

    In plain wordsIn mice lacking the beta(3) receptor, AOD9604 raised fat burning in a short-term test.

    Peptide
    AOD-9604
    Outcome
    IncreaseFat oxidation in acute experiment
    Study

    micen: not reported in source

    beta(3)-AR knock-out mice
    Outcome group
    Fat metabolism and adipogenesis · Metabolic and weight
    Studied dose
    Dose not stated

    Source sentences

    Summary
    However, in an acute experiment, AOD9604 was capable of increasing energy expenditure and fat oxidation in the beta(3)-AR knock-out mice.
  9. 09AnimalAnimal study (in vivo)Efficacy outcome

    In wild-type control mice, long-term AOD9604 produced a change in body weight that was not seen in beta(3)-AR knock-out mice.

    In plain wordsIn normal mice, long-term AOD9604 changed body weight, but this did not happen in mice lacking the beta(3) receptor.

    Peptide
    AOD-9604
    Outcome
    Direction not reportedBody weight change in wild-type mice
    Study

    micen: not reported in source

    wild-type control mice
    Outcome group
    Body weight · Metabolic and weight
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The importance of beta(3)-AR was verified when long-term treatment with hGH and AOD9604 in beta(3)-AR knock-out mice failed to produce the change in body weight and increase in lipolysis that was observed in wild-type control mice.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    9 Oct 2026, 18:17 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:47 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

PepBank is a research reference. Talk to a doctor before you use any peptide.