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Study · Not a test of the peptide alone · 2001

2 results

Direct modification of somatotrope function by long-term leptin treatment of primary cultured ovine pituitary cells.

Roh SG, Nie GY, Loneragan K, Gertler A, Chen C

Endocrinology1 Dec 2001Cited by 29 (Europe PMC)

PMID11713211 (opens in a new tab)DOI10.1210/endo.142.12.8559 (opens in a new tab)PepBankPUB-11713211
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone2

In this study, GHRP-2 was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking GHRP-2.

  1. 01LabNot a test of GHRP-2 aloneIn vitro (cells)Mechanism

    In primary cultured ovine pituitary cells, three-day leptin treatment increased the GH response to GHRP‑2 stimulation.

    In plain wordsIn sheep pituitary cells, three days of leptin treatment increased the GH response to GHRP‑2.

    Peptide
    GHRP-2
    Outcome
    IncreaseGH response to GHRP-2 stimulation after leptin
    Study

    sheepn: not reported in source

    primary cultured ovine pituitary cells
    Comparator
    Untreated cells
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones

    Source sentences

    Summary
    but the GH response to GHRP-2 stimulation was increased.
    1 context sentence
    Summary · context
    Here we report a direct action of recombinant ovine leptin on primary cultured ovine somatotropes by analyzing the levels of mRNA encoding for GH or the receptors for GHRH (GHRH-R) and GH-releasing peptides (GHRP).

    In this study, GHRP-2 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHRP-2.

  2. 02LabNot a test of GHRP-2 aloneIn vitro (cells)Mechanism

    In primary cultured ovine pituitary cells, leptin treatment did not alter the combined effect of GHRH and GHRP‑2 on GH secretion.

    In plain wordsIn sheep pituitary cells, leptin did not change the combined effect of GHRH and GHRP‑2 on GH release.

    Peptide
    GHRP-2
    Outcome
    No significant changeGH response to GHRH plus GHRP-2 after leptin
    Study

    sheepn: not reported in source

    primary cultured ovine pituitary cells
    Comparator
    Untreated cells
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones

    Source sentences

    Summary
    The combined effect of GHRH and GHRP-2 on GH secretion was not altered by treatment of the cells with leptin.
    1 context sentence
    Summary · context
    Here we report a direct action of recombinant ovine leptin on primary cultured ovine somatotropes by analyzing the levels of mRNA encoding for GH or the receptors for GHRH (GHRH-R) and GH-releasing peptides (GHRP).

    In this study, GHRP-2 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHRP-2.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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