[Effect of epithalone on growth kinetics and functional morphology of M-1 sarcoma].

Khavinson VKh, Iuzhakov VV, Kvetnoĭ IM, Malinin VV

Voprosy onkologii1 Jan 2001Cited by 4 (Europe PMC)

PMID11710291PepBankPUB-11710291

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

6 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Efficacy outcome
In rats with transplanted M-1 sarcoma, epitalon injection inhibited tumor growth.
In plain wordsIn rats, epitalon injection slowed the growth of a transplanted sarcoma.
Peptide
Epitalon
Outcome
DecreaseM-1 sarcoma growth
Study
ratn: not reported in source
subcutaneously transplanted M-1 sarcoma
Outcome group
Tumor growth · Cancer
Studied dose
2.5 micrograms/kg · injectionAs given in this study (rat).
Source sentences
Summary
The growth of subcutaneously-transplanted sarcoma M-1 in rat was inhibited by injection of a synthetic tetrapeptide--epitalon (2.5 (micrograms/kg).
Report a problemFND-1171029101
02AnimalAnimal study (in vivo)Efficacy outcome
In rats with transplanted M-1 sarcoma, the growth inhibition by epitalon lasted for two weeks after the injection course.
In plain wordsIn rats, the slowing of sarcoma growth by epitalon lasted two weeks after the injections ended.
Peptide
Epitalon
Outcome
DecreaseDuration of tumor growth inhibition
Study
ratn: not reported in source
subcutaneously transplanted M-1 sarcoma
Outcome group
Tumor growth · Cancer
Studied dose
2.5 micrograms/kg · injectionAs given in this study (rat).
Source sentences
Summary
The effect lasted for two weeks after injection course.
1 context sentence(design, population, supporting numbers)
Summary · context
The growth of subcutaneously-transplanted sarcoma M-1 in rat was inhibited by injection of a synthetic tetrapeptide--epitalon (2.5 (micrograms/kg).
Report a problemFND-1171029102
03AnimalAnimal study (in vivo)Mechanism
In rats with transplanted M-1 sarcoma, proliferative activity of the tumor decreased after epitalon.
In plain wordsIn rats, epitalon lowered the rate of tumor cell proliferation.
Peptide
Epitalon
Outcome
DecreaseTumor proliferative activity
Study
ratn: not reported in source
subcutaneously transplanted M-1 sarcoma
Outcome group
Tumor growth · Cancer
Studied dose
2.5 micrograms/kg · injectionAs given in this study (rat).
Source sentences
Summary
Decrease in proliferative activity
1 context sentence(design, population, supporting numbers)
Summary · context
The growth of subcutaneously-transplanted sarcoma M-1 in rat was inhibited by injection of a synthetic tetrapeptide--epitalon (2.5 (micrograms/kg).
Report a problemFND-1171029103
04AnimalAnimal study (in vivo)Mechanism
In rats with transplanted M-1 sarcoma, the decrease in proliferative activity was not associated with an immediate cytostatic action of epitalon on tumor cells.
In plain wordsIn rats, epitalon did not act by directly stopping tumor cell division.
Peptide
Epitalon
Outcome
No significant changeDirect cytostatic action on tumor cells
Study
ratn: not reported in source
subcutaneously transplanted M-1 sarcoma
Outcome group
Tumor growth · Cancer
Studied dose
2.5 micrograms/kg · injectionAs given in this study (rat).
Source sentences
Summary
Decrease in proliferative activity was not associated with the drug's immediate cytostatic action on tumor cells.
1 context sentence(design, population, supporting numbers)
Summary · context
The growth of subcutaneously-transplanted sarcoma M-1 in rat was inhibited by injection of a synthetic tetrapeptide--epitalon (2.5 (micrograms/kg).
Report a problemFND-1171029104
05AnimalAnimal study (in vivo)Mechanism
In rats with transplanted M-1 sarcoma, epitalon produced morphological signs of hemorrhagic necrosis of the tumor.
In plain wordsIn rats, epitalon caused signs of bleeding and tissue death in the tumor.
Peptide
Epitalon
Outcome
IncreaseHemorrhagic necrosis of tumor
Study
ratn: not reported in source
subcutaneously transplanted M-1 sarcoma
Outcome group
Tumor growth · Cancer
Studied dose
2.5 micrograms/kg · injectionAs given in this study (rat).
Source sentences
Summary
hemorrhagic necrosis of tumor
1 context sentence(design, population, supporting numbers)
Summary · context
The growth of subcutaneously-transplanted sarcoma M-1 in rat was inhibited by injection of a synthetic tetrapeptide--epitalon (2.5 (micrograms/kg).
Report a problemFND-1171029105
06AnimalAnimal study (in vivo)Mechanism
In rats with transplanted M-1 sarcoma, epitalon increased apoptosis of tumor cells.
In plain wordsIn rats, epitalon increased programmed death of tumor cells.
Peptide
Epitalon
Outcome
IncreaseApoptosis of tumor cells
Study
ratn: not reported in source
subcutaneously transplanted M-1 sarcoma
Outcome group
Tumor growth · Cancer
Studied dose
2.5 micrograms/kg · injectionAs given in this study (rat).
Source sentences
Summary
increased apoptosis of tumor cells.
1 context sentence(design, population, supporting numbers)
Summary · context
The growth of subcutaneously-transplanted sarcoma M-1 in rat was inhibited by injection of a synthetic tetrapeptide--epitalon (2.5 (micrograms/kg).
Report a problemFND-1171029106

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
12 Oct 2026, 17:28 UTC
Study results updated
Version 1
9 Oct 2026, 02:47 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

MeSH terms

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