In cultured rat nucleus pulposus cells from 40-week-old animals, Long R3 IGF-I upregulated proteoglycan synthesis compared with IGF-I.
In plain wordsIn rat disc cells grown in a dish, an IGF-I analogue raised proteoglycan synthesis more than natural IGF-I did.
- Peptide
- IGF-1 LR3
- Outcome
- IncreaseProteoglycan synthesis in 40-week cells
- Study
ratn: not reported in source
cultured nucleus pulposus cells from 40-week-old rats- Comparator
- IGF-I
- Outcome group
- Bone and joint · Musculoskeletal
- Studied dose
- Dose not stated
Source sentences
Furthermore, proteoglycan synthesis in 40-week cells supplemented with Long R3 insulin-like growth factor-I was upregulated in comparison with that in 40-week cells supplemented with insulin-like growth factor-I.
2 context sentences(design, population, supporting numbers)
Nucleus pulposus tissue and cells were obtained from the coccygeal vertebrae of 8-week-old, 40-week-old, and 120-week-old rats.
Thus, the expression of insulin-like growth factor binding protein-1 and proteoglycan synthesis was investigated by use of Long R3 insulin-like growth factor-I, which was not influenced by insulin-like growth factor binding proteins.