Skip to content

Study · Not a test of the peptide alone · 2001

1 result

IGFBPs modulate IGF-I- and high glucose-controlled growth of human retinal endothelial cells.

Giannini S, Cresci B, Pala L, Ciucci A, Franchini A, Manuelli C, Fujita-Yamaguchi Y, Cappugi P, Zonefrati R, Rotella CM

The Journal of endocrinology1 Nov 2001Cited by 17 (Europe PMC)

PMID11691647 (opens in a new tab)DOI10.1677/joe.0.1710273 (opens in a new tab)PepBankPUB-11691647
Source linkPubMedAsk about this study
Jump to 1 result

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study1

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone1

In this study, IGF-1 DES (des(1-3)IGF-I) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking IGF-1 DES (des(1-3)IGF-I).

  1. 01LabNot a test of IGF-1 DES (des(1-3)IGF-I) aloneIn vitro (cells)Mechanism

    In retinal endothelial cells, tests including low-IGFBP-affinity des(1‑3)IGF-I indicated that IGF-I interaction with IGFBP-5 was necessary for IGFBP-5 detachment.

    In plain wordsIn cells, tests with des(1‑3)IGF-I indicated that IGF-I must interact with IGFBP-5 to detach it from binding sites.

    Peptide
    IGF-1 DES (des(1-3)IGF-I)
    Outcome
    Not applicableIGFBP-5 detachment mechanism
    Study

    humann: not reported in source

    Human retinal endothelial cells
    Outcome group
    Receptor activity and mechanism · Eye

    Source sentences

    Summary
    Studies using an antibody (alpha IR3) against the IGF-I receptor, and compounds with low affinity for IGFBPs, such as insulin and des(1-3)IGF-I, showed that an interaction between IGF-I and IGFBP-5 was necessary to detach this IGFBP from its binding sites.
    1 context sentence
    Summary · context
    We investigated the effects of IGF-I and increased glucose concentrations on the release of IGFBPs and the growth of human retinal endothelial cells (HRECs).

    In this study, IGF-1 DES (des(1-3)IGF-I) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking IGF-1 DES (des(1-3)IGF-I).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 2

    21 Oct 2026, 13:52 UTC

    Study data updated · source update from Europe PMC

  3. Version 1

    21 Oct 2026, 12:50 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

PepBank is a research reference. Talk to a doctor before you use any peptide.