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Study · Animal study (in vivo) · chicken · 2002

5 results

The effects of thymulin on macrophage responsiveness to interferon-gamma.

Orringer DA, Staeheli P, Marsh JA

Developmental and comparative immunology1 Jan 2002Cited by 4 (Europe PMC)

PMID11687267 (opens in a new tab)DOI10.1016/s0145-305x(01)00052-0 (opens in a new tab)PepBankPUB-11687267
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

5 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Activity measurement

    In chickens, thymulin at 10 ng per 100 g for one or two days increased macrophage responsiveness to ChIFN-gamma.

    In plain wordsIn chickens, thymulin at 10 ng per 100 g increased macrophage responsiveness to ChIFN-gamma compared with no thymulin.

    Peptide
    Thymulin (serum thymic factor)
    Outcome
    IncreaseMacrophage responsiveness at 10 ng
    Study

    chickenn: not reported in source

    seven-week-old chickens; abdominal exudate macrophages tested after treatment
    Comparator
    0 ng thymulin
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    10 ng per 100 g body weight · 1 and 2 daysAs given in this study (chicken).

    Source sentences

    Summary
    One and 2-day thymulin treatment at 10 and 100ng per 100g body weight doses significantly increased responsiveness to ChIFN-gamma while 1ng per 100g body weight had no effect.
    1 context sentence
    Summary · context
    Seven-week-old chickens were treated with 0, 1, 10, or 100ng thymulin per 100g body weight. Abdominal exudate cells (AEC), a source of macrophages, were harvested and cultured in the presence of graded levels of recombinant chicken interferon-gamma (ChIFN-gamma). Responsiveness to ChIFN-gamma was de…
  2. 02AnimalAnimal study (in vivo)Activity measurement

    In chickens, thymulin at 100 ng per 100 g for one or two days increased macrophage responsiveness to ChIFN-gamma.

    In plain wordsIn chickens, thymulin at 100 ng per 100 g increased macrophage responsiveness to ChIFN-gamma compared with no thymulin.

    Peptide
    Thymulin (serum thymic factor)
    Outcome
    IncreaseMacrophage responsiveness at 100 ng
    Study

    chickenn: not reported in source

    seven-week-old chickens; abdominal exudate macrophages tested after treatment
    Comparator
    0 ng thymulin
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    100 ng per 100 g body weight · 1 and 2 daysAs given in this study (chicken).

    Source sentences

    Summary
    One and 2-day thymulin treatment at 10 and 100ng per 100g body weight doses significantly increased responsiveness to ChIFN-gamma while 1ng per 100g body weight had no effect.
    1 context sentence
    Summary · context
    Seven-week-old chickens were treated with 0, 1, 10, or 100ng thymulin per 100g body weight. Abdominal exudate cells (AEC), a source of macrophages, were harvested and cultured in the presence of graded levels of recombinant chicken interferon-gamma (ChIFN-gamma). Responsiveness to ChIFN-gamma was de…
  3. 03AnimalAnimal study (in vivo)Activity measurement

    In chickens, thymulin at 1 ng per 100 g had no effect on macrophage responsiveness to ChIFN-gamma.

    In plain wordsIn chickens, thymulin at 1 ng per 100 g did not change macrophage responsiveness to ChIFN-gamma compared with no thymulin.

    Peptide
    Thymulin (serum thymic factor)
    Outcome
    No significant changeMacrophage responsiveness at 1 ng
    Study

    chickenn: not reported in source

    seven-week-old chickens; abdominal exudate macrophages tested after treatment
    Comparator
    0 ng thymulin
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    1 ng per 100 g body weight · 1 and 2 daysAs given in this study (chicken).

    Source sentences

    Summary
    One and 2-day thymulin treatment at 10 and 100ng per 100g body weight doses significantly increased responsiveness to ChIFN-gamma while 1ng per 100g body weight had no effect.
    1 context sentence
    Summary · context
    Seven-week-old chickens were treated with 0, 1, 10, or 100ng thymulin per 100g body weight. Abdominal exudate cells (AEC), a source of macrophages, were harvested and cultured in the presence of graded levels of recombinant chicken interferon-gamma (ChIFN-gamma). Responsiveness to ChIFN-gamma was de…
  4. 04AnimalAnimal study (in vivo)Activity measurement

    In chickens, the thymulin dose needed to increase ChIFN-gamma responsiveness differed between Cornell K and sex-linked dwarf strains.

    In plain wordsIn chickens, the thymulin dose needed to increase ChIFN-gamma responsiveness differed between Cornell K and sex-linked dwarf strains.

    Peptide
    Thymulin (serum thymic factor)
    Outcome
    Direction not reportedStrain-dependent effective dose
    Study

    chickenn: not reported in source

    Cornell K and sex-linked dwarf chickens
    Comparator
    Cornell K versus sex-linked dwarf chickens
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The dose of thymulin treatment required to significantly increase responsiveness to ChIFN-gamma differed between strains.
    1 context sentence
    Summary · context
    Other experiments compared the effect of thymulin treatments in Cornell K strain chickens, having normal serum thymulin levels with sex-linked dwarf (SLD) chickens which are deficient in serum thymulin.
  5. 05LabIn vitro (cells)Activity measurement

    In HD-11 macrophages, direct thymulin exposure produced no significant increase in ChIFN-gamma responsiveness between treatment groups.

    In plain wordsIn cells, direct thymulin treatment did not significantly increase ChIFN-gamma responsiveness compared with other treatment groups.

    Peptide
    Thymulin (serum thymic factor)
    Outcome
    No significant changeDirect macrophage responsiveness to ChIFN-gamma
    Study

    chickenn: not reported in source

    HD-11 macrophage cell line
    Comparator
    other thymulin treatment groups
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    0-200 pg/mlAs given in this study (chicken).

    Source sentences

    Summary
    There were no significant increases in responsiveness to ChIFN-gamma between treatment groups within the macrophage cell line, HD-11, when cultured in the presence of 0-200pg thymulin/ml.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 2

    21 Oct 2026, 13:55 UTC

    Study data updated · source update from Europe PMC

  3. Version 1

    21 Oct 2026, 12:50 UTC

    First added · source update from Europe PMC

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