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Study · Animal study (in vivo) · mouse · 2001

7 results

Increase of fat oxidation and weight loss in obese mice caused by chronic treatment with human growth hormone or a modified C-terminal fragment.

Heffernan MA, Thorburn AW, Fam B, Summers R, Conway-Campbell B, Waters MJ, Ng FM

International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity1 Oct 2001Cited by 25 (Europe PMC)

PMID11673763 (opens in a new tab)DOI10.1038/sj.ijo.0801740 (opens in a new tab)PepBankPUB-11673763
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study7

7 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In obese mice, AOD9604 significantly reduced body weight gain.

    In plain wordsIn obese mice, AOD9604 reduced weight gain.

    Peptide
    AOD-9604
    Outcome
    DecreaseBody weight gain
    Study

    micen: not reported in source

    obese (ob/ob) mice
    Comparator
    Saline
    Outcome group
    Body weight · Metabolic and weight
    Studied dose
    Dose not stated · mini-osmotic pumps · 14 daysAs given in this study (mice).

    Source sentences

    Summary
    Both hGH and AOD significantly reduced body weight gain in obese mice.
    1 context sentence
    Summary · context
    Obese and lean mice were treated with hGH, AOD or saline for 14 days using mini-osmotic pumps.
  2. 02AnimalAnimal study (in vivo)Mechanism

    In obese mice, AOD9604 treatment, which reduced weight gain, was associated with increased in vivo fat oxidation.

    In plain wordsIn obese mice, AOD9604 was linked to more fat burning in the body.

    Peptide
    AOD-9604
    Outcome
    IncreaseIn vivo fat oxidation
    Study

    micen: not reported in source

    obese (ob/ob) mice
    Comparator
    Saline
    Outcome group
    Fat metabolism and adipogenesis · Metabolic and weight
    Studied dose
    Dose not stated · mini-osmotic pumps · 14 daysAs given in this study (mice).

    Source sentences

    Summary
    Both hGH and AOD significantly reduced body weight gain in obese mice. This was associated with increased in vivo fat oxidation and increased plasma glycerol levels (an index of lipolysis).
    1 context sentence
    Summary · context
    Obese and lean mice were treated with hGH, AOD or saline for 14 days using mini-osmotic pumps.
  3. 03AnimalAnimal study (in vivo)Mechanism

    In obese mice, AOD9604 treatment was associated with increased plasma glycerol, an index of lipolysis.

    In plain wordsIn obese mice, AOD9604 was linked to higher blood glycerol, a sign of fat breakdown.

    Peptide
    AOD-9604
    Outcome
    IncreasePlasma glycerol (index of lipolysis)
    Study

    micen: not reported in source

    obese (ob/ob) mice
    Comparator
    Saline
    Outcome group
    Fat metabolism and adipogenesis · Metabolic and weight
    Studied dose
    Dose not stated · mini-osmotic pumps · 14 daysAs given in this study (mice).

    Source sentences

    Summary
    Both hGH and AOD significantly reduced body weight gain in obese mice. This was associated with increased in vivo fat oxidation and increased plasma glycerol levels (an index of lipolysis).
    1 context sentence
    Summary · context
    Obese and lean mice were treated with hGH, AOD or saline for 14 days using mini-osmotic pumps.
  4. 04AnimalAnimal study (in vivo)Safety outcome

    In obese mice, AOD9604 did not induce hyperglycaemia, unlike hGH.

    In plain wordsIn obese mice, AOD9604 did not raise blood sugar, unlike human growth hormone.

    Peptide
    AOD-9604
    Outcome
    No significant changeHyperglycaemia
    Study

    micen: not reported in source

    obese (ob/ob) mice
    Outcome group
    Glycemic control · Metabolic and weight
    Studied dose
    Dose not stated · mini-osmotic pumps · 14 daysAs given in this study (mice).

    Source sentences

    Summary
    Unlike hGH, however, AOD9604 did not induce hyperglycaemia or reduce insulin secretion.
    1 context sentence
    Summary · context
    Obese and lean mice were treated with hGH, AOD or saline for 14 days using mini-osmotic pumps.
  5. 05AnimalAnimal study (in vivo)Safety outcome

    In obese mice, AOD9604 did not reduce insulin secretion, unlike hGH.

    In plain wordsIn obese mice, AOD9604 did not lower insulin release, unlike human growth hormone.

    Peptide
    AOD-9604
    Outcome
    No significant changeInsulin secretion
    Study

    micen: not reported in source

    obese (ob/ob) mice
    Outcome group
    Glycemic control · Metabolic and weight
    Studied dose
    Dose not stated · mini-osmotic pumps · 14 daysAs given in this study (mice).

    Source sentences

    Summary
    Unlike hGH, however, AOD9604 did not induce hyperglycaemia or reduce insulin secretion.
    1 context sentence
    Summary · context
    Obese and lean mice were treated with hGH, AOD or saline for 14 days using mini-osmotic pumps.
  6. 06LabIn vitro (cells)Activity measurement

    In cells with the hGH receptor, AOD9604 did not compete with hGH for receptor binding.

    In plain wordsIn lab cells, AOD9604 did not compete with human growth hormone for its receptor.

    Peptide
    AOD-9604
    Outcome
    No significant changeCompetition for hGH receptor binding
    Study

    n: not reported in source

    BaF-BO3 cells transfected with the hGH receptor
    Outcome group
    Receptor activity and mechanism · Pharmacology
    Studied dose
    Dose not stated

    Source sentences

    Summary
    AOD9604 does not compete for the hGH receptor and nor does it induce cell proliferation, unlike hGH.
    1 context sentence
    Summary · context
    BaF-BO3 cells transfected with the hGH receptor were used to measure in vitro 125I-hGH receptor binding and cell proliferation.
  7. 07LabIn vitro (cells)Activity measurement

    In cells with the hGH receptor, AOD9604 did not induce cell proliferation, unlike hGH.

    In plain wordsIn lab cells, AOD9604 did not make cells multiply, unlike human growth hormone.

    Peptide
    AOD-9604
    Outcome
    No significant changeCell proliferation via hGH receptor
    Study

    n: not reported in source

    BaF-BO3 cells transfected with the hGH receptor
    Outcome group
    Receptor activity and mechanism · Pharmacology
    Studied dose
    Dose not stated

    Source sentences

    Summary
    AOD9604 does not compete for the hGH receptor and nor does it induce cell proliferation, unlike hGH.
    1 context sentence
    Summary · context
    BaF-BO3 cells transfected with the hGH receptor were used to measure in vitro 125I-hGH receptor binding and cell proliferation.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    27 Oct 2026, 16:37 UTC

    Study data updated · source update from Europe PMC

  2. Version 2

    9 Oct 2026, 18:17 UTC

    Study results updated

  3. Version 1

    9 Oct 2026, 02:47 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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