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Study · Animal study (in vivo) · rat · 2001

3 results

Inhibitory effect of peptide vilon on the development of induced rat urinary bladder tumors in rats.

Pliss GB, Mel'nikov AS, Malinin VV, Khavinson VK

Bulletin of experimental biology and medicine1 Jun 2001Cited by 1 (Europe PMC)

PMID11586406 (opens in a new tab)DOI10.1023/a:1012354603132 (opens in a new tab)PepBankPUB-11586406
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In rats with induced bladder carcinogenesis, tumors developed in 56% of vilon-treated animals versus 75.5% of controls.

    In plain wordsIn rats, bladder tumors developed in 56% of vilon-treated animals versus 75.5% of controls.

    Peptide
    Vilon (KE)
    Outcome
    DecreaseUrinary bladder tumor incidence
    Study

    ratn: not reported in source

    N-butyl-N-(4-hydroxybutyl)nitrosamine-induced urinary bladder carcinogenesis
    Comparator
    Controls
    Outcome group
    Tumor growth · Cancer
    Studied dose
    Dose not stated

    Measurements

    Tumor incidence
    56%
    vilon-treated animals
    Tumor incidence
    75.5%
    controls

    Source sentences

    Summary
    The tumors developed in 56% vilon-treated animals and in 75.5% controls.
    1 context sentence
    Summary · context
    The effect of peptide vilon (Lys-Glu) on urinary bladder carcinogenesis in rats was studied. Urinary bladder tumors were induced with a selective carcinogen N-butyl-N-(4-hydroxybutyl)nitrosamine.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In rats with induced bladder carcinogenesis, vilon decreased the incidence of preneoplastic bladder mucosal changes 2-fold versus controls.

    In plain wordsIn rats, vilon halved the incidence of preneoplastic bladder changes compared with controls.

    Peptide
    Vilon (KE)
    Outcome
    DecreasePreneoplastic bladder mucosal changes
    Study

    ratn: not reported in source

    N-butyl-N-(4-hydroxybutyl)nitrosamine-induced urinary bladder carcinogenesis
    Comparator
    Controls
    Outcome group
    Tumor growth · Cancer
    Studied dose
    Dose not stated

    Measurements

    Incidence reduction
    2 fold
    preneoplastic bladder mucosal changes

    Source sentences

    Summary
    Vilon 2-fold decreased the incidence of preneoplastic and early neoplastic changes in urinary bladder mucosa and significantly inhibited carcinogenesis.
    1 context sentence
    Summary · context
    The effect of peptide vilon (Lys-Glu) on urinary bladder carcinogenesis in rats was studied. Urinary bladder tumors were induced with a selective carcinogen N-butyl-N-(4-hydroxybutyl)nitrosamine.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In rats with induced bladder carcinogenesis, vilon decreased the incidence of early neoplastic bladder mucosal changes 2-fold versus controls.

    In plain wordsIn rats, vilon halved the incidence of early neoplastic bladder changes compared with controls.

    Peptide
    Vilon (KE)
    Outcome
    DecreaseEarly neoplastic bladder mucosal changes
    Study

    ratn: not reported in source

    N-butyl-N-(4-hydroxybutyl)nitrosamine-induced urinary bladder carcinogenesis
    Comparator
    Controls
    Outcome group
    Tumor growth · Cancer
    Studied dose
    Dose not stated

    Measurements

    Incidence reduction
    2 fold
    early neoplastic bladder mucosal changes

    Source sentences

    Summary
    Vilon 2-fold decreased the incidence of preneoplastic and early neoplastic changes in urinary bladder mucosa and significantly inhibited carcinogenesis.
    1 context sentence
    Summary · context
    The effect of peptide vilon (Lys-Glu) on urinary bladder carcinogenesis in rats was studied. Urinary bladder tumors were induced with a selective carcinogen N-butyl-N-(4-hydroxybutyl)nitrosamine.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    21 Oct 2026, 17:05 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 16:35 UTC

    First added · source update from Europe PMC

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