Interactions between follicle-stimulating hormone and growth factors in modulating secretion of steroids and inhibin-related peptides by nonluteinized bovine granulosa cells.

Glister C, Tannetta DS, Groome NP, Knight PG

Biology of reproduction1 Oct 2001Cited by 85 (Europe PMC)

PMID11566722DOI10.1095/biolreprod65.4.1020PepBankPUB-11566722

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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study9

8 results from studies that gave the peptide. No result from this study comes from people.

01LabIn vitro (cells)Activity measurement
In bovine granulosa cells, LR3 IGF-I alone markedly increased inhibin A output.
In plain wordsIn cow ovarian cells in a dish, an IGF-I analogue markedly increased inhibin A output.
Peptide
IGF-1 LR3
Outcome
IncreaseInhibin A output
Study
bovinen: not reported in source
nonluteinized bovine granulosa cells in serum-free culture
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
2-50 ng/ml · 144 hAs given in this study (bovine).
Measurements
Inhibin A output
8 fold
LR3 IGF-I alone
Source sentences
Summary
LR3 IGF-I alone markedly increased (P < 0.0001) output of inh A (8-fold)
2 context sentences(design, population, supporting numbers)
Summary · context
The aim was to investigate potential interactions between FSH and intraovarian growth factors in modulating secretion of inhibin A (inh A), activin A (act A), follistatin (FS), estradiol (E2), and progesterone (P4) by bovine granulosa cells cultured under conditions in which a nonluteinized FSH-resp…
Summary · context
Cells from 4- to 6-mm follicles were cultured in serum-free medium containing insulin (10 ng/ml) and androstenedione (10(-7) M), and effects of ovine FSH (0.037-3 ng/ml) were tested alone and in combination with insulin-like growth factors (IGF) (LR3 IGF-I analogue; 2-50 ng/ml) and epidermal growth…
Report a problemFND-1156672201
02LabIn vitro (cells)Activity measurement
In bovine granulosa cells, LR3 IGF-I alone markedly increased activin A output.
In plain wordsIn cow ovarian cells in a dish, an IGF-I analogue markedly increased activin A output.
Peptide
IGF-1 LR3
Outcome
IncreaseActivin A output
Study
bovinen: not reported in source
nonluteinized bovine granulosa cells in serum-free culture
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
2-50 ng/ml · 144 hAs given in this study (bovine).
Measurements
Activin A output
41 fold
LR3 IGF-I alone
Source sentences
Summary
LR3 IGF-I alone markedly increased (P < 0.0001) output of inh A (8-fold), act A (41-fold)
2 context sentences(design, population, supporting numbers)
Summary · context
The aim was to investigate potential interactions between FSH and intraovarian growth factors in modulating secretion of inhibin A (inh A), activin A (act A), follistatin (FS), estradiol (E2), and progesterone (P4) by bovine granulosa cells cultured under conditions in which a nonluteinized FSH-resp…
Summary · context
Cells from 4- to 6-mm follicles were cultured in serum-free medium containing insulin (10 ng/ml) and androstenedione (10(-7) M), and effects of ovine FSH (0.037-3 ng/ml) were tested alone and in combination with insulin-like growth factors (IGF) (LR3 IGF-I analogue; 2-50 ng/ml) and epidermal growth…
Report a problemFND-1156672202
03LabIn vitro (cells)Activity measurement
In bovine granulosa cells, LR3 IGF-I alone markedly increased follistatin output.
In plain wordsIn cow ovarian cells in a dish, an IGF-I analogue markedly increased follistatin output.
Peptide
IGF-1 LR3
Outcome
IncreaseFollistatin output
Study
bovinen: not reported in source
nonluteinized bovine granulosa cells in serum-free culture
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
2-50 ng/ml · 144 hAs given in this study (bovine).
Measurements
Follistatin output
12 fold
LR3 IGF-I alone
Source sentences
Summary
LR3 IGF-I alone markedly increased (P < 0.0001) output of inh A (8-fold), act A (41-fold), FS (12-fold)
2 context sentences(design, population, supporting numbers)
Summary · context
The aim was to investigate potential interactions between FSH and intraovarian growth factors in modulating secretion of inhibin A (inh A), activin A (act A), follistatin (FS), estradiol (E2), and progesterone (P4) by bovine granulosa cells cultured under conditions in which a nonluteinized FSH-resp…
Summary · context
Cells from 4- to 6-mm follicles were cultured in serum-free medium containing insulin (10 ng/ml) and androstenedione (10(-7) M), and effects of ovine FSH (0.037-3 ng/ml) were tested alone and in combination with insulin-like growth factors (IGF) (LR3 IGF-I analogue; 2-50 ng/ml) and epidermal growth…
Report a problemFND-1156672203
04LabIn vitro (cells)Activity measurement
In bovine granulosa cells, LR3 IGF-I alone markedly increased estradiol output.
In plain wordsIn cow ovarian cells in a dish, an IGF-I analogue markedly increased estradiol output.
Peptide
IGF-1 LR3
Outcome
IncreaseEstradiol output
Study
bovinen: not reported in source
nonluteinized bovine granulosa cells in serum-free culture
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
2-50 ng/ml · 144 hAs given in this study (bovine).
Measurements
Estradiol output
18 fold
LR3 IGF-I alone
Source sentences
Summary
LR3 IGF-I alone markedly increased (P < 0.0001) output of inh A (8-fold), act A (41-fold), FS (12-fold), and E2 (18-fold)
2 context sentences(design, population, supporting numbers)
Summary · context
The aim was to investigate potential interactions between FSH and intraovarian growth factors in modulating secretion of inhibin A (inh A), activin A (act A), follistatin (FS), estradiol (E2), and progesterone (P4) by bovine granulosa cells cultured under conditions in which a nonluteinized FSH-resp…
Summary · context
Cells from 4- to 6-mm follicles were cultured in serum-free medium containing insulin (10 ng/ml) and androstenedione (10(-7) M), and effects of ovine FSH (0.037-3 ng/ml) were tested alone and in combination with insulin-like growth factors (IGF) (LR3 IGF-I analogue; 2-50 ng/ml) and epidermal growth…
Report a problemFND-1156672204
05LabIn vitro (cells)Activity measurement
In bovine granulosa cells, LR3 IGF-I alone modestly increased progesterone output.
In plain wordsIn cow ovarian cells in a dish, an IGF-I analogue modestly increased progesterone output.
Peptide
IGF-1 LR3
Outcome
IncreaseProgesterone output
Study
bovinen: not reported in source
nonluteinized bovine granulosa cells in serum-free culture
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
2-50 ng/ml · 144 hAs given in this study (bovine).
Measurements
Progesterone output
≈ 2.5 fold
LR3 IGF-I alone
Source sentences
Summary
this was accompanied by modest increases (P < 0.01) in P4 output ( approximately 2.5-fold)
2 context sentences(design, population, supporting numbers)
Summary · context
The aim was to investigate potential interactions between FSH and intraovarian growth factors in modulating secretion of inhibin A (inh A), activin A (act A), follistatin (FS), estradiol (E2), and progesterone (P4) by bovine granulosa cells cultured under conditions in which a nonluteinized FSH-resp…
Summary · context
Cells from 4- to 6-mm follicles were cultured in serum-free medium containing insulin (10 ng/ml) and androstenedione (10(-7) M), and effects of ovine FSH (0.037-3 ng/ml) were tested alone and in combination with insulin-like growth factors (IGF) (LR3 IGF-I analogue; 2-50 ng/ml) and epidermal growth…
Report a problemFND-1156672205
06LabIn vitro (cells)Activity measurement
In bovine granulosa cells, LR3 IGF-I alone modestly increased cell number.
In plain wordsIn cow ovarian cells in a dish, an IGF-I analogue modestly increased the number of cells.
Peptide
IGF-1 LR3
Outcome
IncreaseGranulosa cell number
Study
bovinen: not reported in source
nonluteinized bovine granulosa cells in serum-free culture
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
2-50 ng/ml · 144 hAs given in this study (bovine).
Measurements
Cell number
≈ 2 fold
LR3 IGF-I alone
Source sentences
Summary
this was accompanied by modest increases (P < 0.01) in P4 output ( approximately 2.5-fold) and cell number ( approximately 2-fold).
2 context sentences(design, population, supporting numbers)
Summary · context
The aim was to investigate potential interactions between FSH and intraovarian growth factors in modulating secretion of inhibin A (inh A), activin A (act A), follistatin (FS), estradiol (E2), and progesterone (P4) by bovine granulosa cells cultured under conditions in which a nonluteinized FSH-resp…
Summary · context
Cells from 4- to 6-mm follicles were cultured in serum-free medium containing insulin (10 ng/ml) and androstenedione (10(-7) M), and effects of ovine FSH (0.037-3 ng/ml) were tested alone and in combination with insulin-like growth factors (IGF) (LR3 IGF-I analogue; 2-50 ng/ml) and epidermal growth…
Report a problemFND-1156672206
07LabIn vitro (cells)Activity measurement
In bovine granulosa cells, LR3 IGF-I alone dose-dependently increased the activin A to follistatin ratio.
In plain wordsIn cow ovarian cells in a dish, an IGF-I analogue increased the activin A to follistatin ratio in a dose-dependent way.
Peptide
IGF-1 LR3
Outcome
IncreaseActivin A to follistatin ratio
Study
bovinen: not reported in source
nonluteinized bovine granulosa cells in serum-free culture
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
2-50 ng/ml · 144 hAs given in this study (bovine).
Measurements
Activin A:follistatin ratio
≈ 3 fold
LR3 IGF-I alone
Source sentences
Summary
Both FSH alone and LR3 IGF-I alone dose-dependently increased the act A:FS ratio ( approximately 3-fold; P < 0.005)
2 context sentences(design, population, supporting numbers)
Summary · context
The aim was to investigate potential interactions between FSH and intraovarian growth factors in modulating secretion of inhibin A (inh A), activin A (act A), follistatin (FS), estradiol (E2), and progesterone (P4) by bovine granulosa cells cultured under conditions in which a nonluteinized FSH-resp…
Summary · context
Cells from 4- to 6-mm follicles were cultured in serum-free medium containing insulin (10 ng/ml) and androstenedione (10(-7) M), and effects of ovine FSH (0.037-3 ng/ml) were tested alone and in combination with insulin-like growth factors (IGF) (LR3 IGF-I analogue; 2-50 ng/ml) and epidermal growth…
Report a problemFND-1156672207
08LabIn vitro (cells)Activity measurement
In bovine granulosa cells, LR3 IGF-I alone dose-dependently increased the activin A to inhibin A ratio.
In plain wordsIn cow ovarian cells in a dish, an IGF-I analogue increased the activin A to inhibin A ratio in a dose-dependent way.
Peptide
IGF-1 LR3
Outcome
IncreaseActivin A to inhibin A ratio
Study
bovinen: not reported in source
nonluteinized bovine granulosa cells in serum-free culture
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
2-50 ng/ml · 144 hAs given in this study (bovine).
Measurements
Activin A:inhibin A ratio
3 to 6 fold
LR3 IGF-I alone
Source sentences
Summary
Both FSH alone and LR3 IGF-I alone dose-dependently increased the act A:FS ratio ( approximately 3-fold; P < 0.005) and act A:inh A ratio (3-fold to 6-fold; P < 0.001)
2 context sentences(design, population, supporting numbers)
Summary · context
The aim was to investigate potential interactions between FSH and intraovarian growth factors in modulating secretion of inhibin A (inh A), activin A (act A), follistatin (FS), estradiol (E2), and progesterone (P4) by bovine granulosa cells cultured under conditions in which a nonluteinized FSH-resp…
Summary · context
Cells from 4- to 6-mm follicles were cultured in serum-free medium containing insulin (10 ng/ml) and androstenedione (10(-7) M), and effects of ovine FSH (0.037-3 ng/ml) were tested alone and in combination with insulin-like growth factors (IGF) (LR3 IGF-I analogue; 2-50 ng/ml) and epidermal growth…
Report a problemFND-1156672208

Studies that did not test the peptide alone1

In this study, IGF-1 LR3 was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking IGF-1 LR3.

09LabNot a test of IGF-1 LR3 aloneIn vitro (cells)Activity measurement
In bovine granulosa cells, adding follistatin suppressed LR3 IGF-I-induced estradiol output.
In plain wordsIn cow ovarian cells in a dish, adding follistatin reduced the estradiol output that an IGF-I analogue had induced.
Peptide
IGF-1 LR3
Outcome
DecreaseEstradiol output induced by LR3 IGF-I after follistatin
Study
bovinen: not reported in source
nonluteinized bovine granulosa cells in serum-free culture
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Source sentences
Summary
addition of FS, to reduce the act A:FS ratio and sequester secreted activin, markedly suppressed (P < 0.001) FSH (3-fold)-, and LR3 IGF-I (2-fold)-induced E2 output.
2 context sentences(design, population, supporting numbers)
Summary · context
The aim was to investigate potential interactions between FSH and intraovarian growth factors in modulating secretion of inhibin A (inh A), activin A (act A), follistatin (FS), estradiol (E2), and progesterone (P4) by bovine granulosa cells cultured under conditions in which a nonluteinized FSH-resp…
Summary · context
Cells from 4- to 6-mm follicles were cultured in serum-free medium containing insulin (10 ng/ml) and androstenedione (10(-7) M), and effects of ovine FSH (0.037-3 ng/ml) were tested alone and in combination with insulin-like growth factors (IGF) (LR3 IGF-I analogue; 2-50 ng/ml) and epidermal growth…
In this study, IGF-1 LR3 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking IGF-1 LR3.
Report a problemFND-1156672209

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
13 Oct 2026, 21:44 UTC
Study results updated
Version 1
13 Oct 2026, 16:31 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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