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Study · Measured the body's own peptide · 2001

2 results

Age-related loss of skeletal muscle function and the inability to express the autocrine form of insulin-like growth factor-1 (MGF) in response to mechanical overload.

Owino V, Yang SY, Goldspink G

FEBS letters1 Sept 2001Cited by 161 (Europe PMC)

PMID11566187 (opens in a new tab)DOI10.1016/s0014-5793(01)02825-3 (opens in a new tab)PepBankPUB-11566187
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

No result from this study comes from a test of the peptide.

Natural levels measured2

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

  1. 01AnimalEndogenous levelAnimal study (in vivo)Mechanism

    In rats with synergistic muscle ablation, older muscles showed considerably lower expression of the local IGF-1 splice variant mechano growth factor (MGF) than young muscles under mechanical overload.

    In plain wordsIn rats, older muscles made much less of the body's own MGF than young muscles when overloaded.

    Peptide
    MGF / PEG-MGF
    Outcome
    DecreaseMGF expression after mechanical overload
    Study

    ratn: not reported in source

    synergistic muscle ablation (mechanical overload)
    Comparator
    Younger muscles
    Outcome group
    Muscle injury and repair · Musculoskeletal

    Source sentences

    Summary
    The significant changes associated with the inability of the older muscles to respond to mechanical overload included the considerably lower expression of the local splice variant mechano growth factor
    1 context sentence
    Summary · context
    The response of insulin-like growth factor-1 (IGF-1) signalling and the capacity of skeletal muscle to adapt to mechanical overload was studied using synergistic muscle ablation.

    This result measures the body's own MGF / PEG-MGF. Nobody was given the peptide. It is not evidence about taking it.

  2. 02AnimalEndogenous levelAnimal study (in vivo)Mechanism

    In rats with mechanical overload, the two muscle IGF-1 splice variants, including MGF, were differentially regulated at the RNA level.

    In plain wordsIn rats, the body's own MGF and the other IGF-1 variant in muscle were controlled differently at the RNA level.

    Peptide
    MGF / PEG-MGF
    Outcome
    MixedRegulation of the two muscle IGF-1 splice variants at RNA level
    Study

    ratn: not reported in source

    synergistic muscle ablation (mechanical overload)
    Outcome group
    Muscle injury and repair · Musculoskeletal

    Source sentences

    Summary
    Two muscle IGF-1 splice variants were measured and found to be differentially regulated at the RNA level.
    1 context sentence
    Summary · context
    The response of insulin-like growth factor-1 (IGF-1) signalling and the capacity of skeletal muscle to adapt to mechanical overload was studied using synergistic muscle ablation.

    This result measures the body's own MGF / PEG-MGF. Nobody was given the peptide. It is not evidence about taking it.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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