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Study · Animal study (in vivo) · rat · 2001

2 results

[Semax prevents elevation of nitric oxide generation caused by incomplete global ischemia in the rat brain].

Fadiukova OE, Alekseev AA, Bashkatova VG, Tolordava IA, Kuzenkov VS, Mikoian VD, Vanin AF, Koshelev VB, Raevskiĭ KS

Eksperimental'naia i klinicheskaia farmakologiia1 Mar 2001Cited by 1 (Europe PMC)

PMID11548444 (opens in a new tab)PepBankPUB-11548444
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Summary

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Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

2 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In Wistar rats with incomplete global ischemia, semax at 0.3 mg/kg prevented the development of neurological disturbances.

    In plain wordsIn rats with reduced brain blood flow, semax prevented the development of nerve-function problems.

    Peptide
    Semax
    Outcome
    DecreaseNeurological disturbances after ischemia
    Study

    ratsn: not reported in source

    Incomplete global ischemia (bilateral common carotid occlusion), Wistar rats
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    0.3 mg/kgAs given in this study (rats).

    Source sentences

    Summary
    The synthetic peptide semax (a fragment of ACTH4-7 Pro-Gly-Pro) in a dose of 0.3 mg/kg prevented from the development of both neurological disturbances and excess NO production in the rat brain cortex.
    1 context sentence
    Summary · context
    A twofold increase in the nitric oxide (NO) production and a moderate increase in the content of secondary products of lipid peroxidation was observed in Wistar rats with incomplete global ischemia model induced by the bilateral occlusion of common carotid arteries.
  2. 02AnimalAnimal study (in vivo)Mechanism

    In Wistar rats with incomplete global ischemia, semax at 0.3 mg/kg prevented excess nitric oxide production in the brain cortex.

    In plain wordsIn rats with reduced brain blood flow, semax prevented the extra nitric oxide that ischemia otherwise caused in the brain cortex.

    Peptide
    Semax
    Outcome
    DecreaseNitric oxide production in brain cortex
    Study

    ratsn: not reported in source

    Incomplete global ischemia (bilateral common carotid occlusion), Wistar rats
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    0.3 mg/kgAs given in this study (rats).

    Source sentences

    Summary
    The synthetic peptide semax (a fragment of ACTH4-7 Pro-Gly-Pro) in a dose of 0.3 mg/kg prevented from the development of both neurological disturbances and excess NO production in the rat brain cortex.
    1 context sentence
    Summary · context
    A twofold increase in the nitric oxide (NO) production and a moderate increase in the content of secondary products of lipid peroxidation was observed in Wistar rats with incomplete global ischemia model induced by the bilateral occlusion of common carotid arteries.

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    12 Oct 2026, 17:28 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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