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Study · Animal study (in vivo) · 2001

6 results

[Behavioral and electrophysiological analysis of the choline-positive effect of nootropic dipeptide acylproline (GVS-111)].

Ostrovskaia RU, Mirzoev TKh, Firova FA, Trofimof SS, Gudasheva TA, Grechenko TN, Gutyrchik EF, Barkova EB

Eksperimental'naia i klinicheskaia farmakologiia1 Mar 2001Cited by 5 (Europe PMC)

PMID11548439 (opens in a new tab)PepBankPUB-11548439
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

4 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In animals with scopolamine-induced long-term memory deficits, GVS-111 promoted recovery of passive avoidance performance.

    In plain wordsIn animals with memory deficits from scopolamine, GVS-111 improved recovery of passive avoidance performance.

    Peptide
    Noopept (omberacetam)
    Outcome
    IncreasePassive avoidance performance recovery
    Study

    n: not reported in source

    scopolamine-induced long-term memory deficit in passive avoidance learning
    Outcome group
    Cognition and memory · Nervous system and cognition
    Studied dose
    0.5 mg/kg/day · 10 daysAs given in this study.

    Source sentences

    Summary
    The behavioral experiments using a passive avoidance learning model showed that the new cognition-enhancing acyl-prolyn containing dipeptide GVS-111 promotes recovery of the test performance in animals with a long-term memory deficit caused by the M-cholinolytic scopolamine (1 mg/kg/day scopolamine…
  2. 02AnimalAnimal study (in vivo)Mechanism

    In behavioral experiments, GVS-111 increased the duration of arecoline-induced tremor.

    In plain wordsIn animals, GVS-111 increased the duration of tremor induced by arecoline.

    Peptide
    Noopept (omberacetam)
    Outcome
    IncreaseArecoline-induced tremor duration
    Study

    n: not reported in source

    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    At the same time, GVS-111 increased the duration of tremor induced by the M-cholinomimetic arecoline.
  3. 03LabEx vivo tissueMechanism

    In isolated Helix Pomatum neurons, GVS-111 increased acetylcholine response amplitude in 75% of neurons.

    In plain wordsIn lab tests of snail neurons, GVS-111 increased the response amplitude to acetylcholine in 75% of neurons.

    Peptide
    Noopept (omberacetam)
    Outcome
    IncreaseAcetylcholine response amplitude
    Study

    Helix Pomatumn: not reported in source

    isolated neurons
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    10(-11) to 10(-9) MAs given in this study (Helix Pomatum).

    Measurements

    Neurons with increased response
    75%
    isolated Helix Pomatum neurons

    Source sentences

    Summary
    The results of electrophysicological experiments showed that GVS-111 in a concentration range from 10(-11) to 10(-9) M increased amplitude of the neural response to acetylcholine (Ach) microappications in 75% of the isolated neurons of Helix Pomatum and produced a predominantly facilitating effect u…
  4. 04LabEx vivo tissueMechanism

    In isolated Helix Pomatum neurons, GVS-111 predominantly facilitated endoneuronal pacemaker activity.

    In plain wordsIn lab tests of snail neurons, GVS-111 mainly increased internal pacemaker activity.

    Peptide
    Noopept (omberacetam)
    Outcome
    IncreaseEndoneuronal pacemaker activity
    Study

    Helix Pomatumn: not reported in source

    isolated neurons
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    10(-11) to 10(-9) MAs given in this study (Helix Pomatum).

    Source sentences

    Summary
    The results of electrophysicological experiments showed that GVS-111 in a concentration range from 10(-11) to 10(-9) M increased amplitude of the neural response to acetylcholine (Ach) microappications in 75% of the isolated neurons of Helix Pomatum and produced a predominantly facilitating effect u…

Studies that did not test the peptide alone2

In this study, Noopept (omberacetam) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Noopept (omberacetam).

  1. 05LabNot a test of Noopept (omberacetam) aloneEx vivo tissueMechanism

    In isolated neurons, scopolamine attenuated or blocked the GVS-111 effect on acetylcholine responses in some neurons.

    In plain wordsIn lab tests, scopolamine reduced or blocked GVS-111's effect on acetylcholine responses in some neurons.

    Peptide
    Noopept (omberacetam)
    Outcome
    DecreaseScopolamine blockade of acetylcholine sensitization
    Study

    Helix Pomatumn: not reported in source

    isolated neurons
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition

    Source sentences

    Summary
    The effect of GVS-111 upon the Ach response in a part of neurons was attenuated or even blocked by scopolamine, and in the other neurons--by the N-cholinolytic d-tubocurarine.
    1 context sentence
    Summary · context
    The results of electrophysicological experiments showed that GVS-111 in a concentration range from 10(-11) to 10(-9) M increased amplitude of the neural response to acetylcholine (Ach) microappications in 75% of the isolated neurons of Helix Pomatum and produced a predominantly facilitating effect u…

    In this study, Noopept (omberacetam) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Noopept (omberacetam).

  2. 06LabNot a test of Noopept (omberacetam) aloneEx vivo tissueMechanism

    In other isolated neurons, d-tubocurarine attenuated or blocked the GVS-111 effect on acetylcholine responses.

    In plain wordsIn lab tests, d-tubocurarine reduced or blocked GVS-111's effect on acetylcholine responses in other neurons.

    Peptide
    Noopept (omberacetam)
    Outcome
    DecreaseTubocurarine blockade of acetylcholine sensitization
    Study

    Helix Pomatumn: not reported in source

    isolated neurons
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition

    Source sentences

    Summary
    The effect of GVS-111 upon the Ach response in a part of neurons was attenuated or even blocked by scopolamine, and in the other neurons--by the N-cholinolytic d-tubocurarine.
    1 context sentence
    Summary · context
    The results of electrophysicological experiments showed that GVS-111 in a concentration range from 10(-11) to 10(-9) M increased amplitude of the neural response to acetylcholine (Ach) microappications in 75% of the isolated neurons of Helix Pomatum and produced a predominantly facilitating effect u…

    In this study, Noopept (omberacetam) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Noopept (omberacetam).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 12:50 UTC

    First added · source update from Europe PMC

Subjects

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