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Study · Animal study (in vivo) · rhesus monkey (macaca mulatta) · 2001

2 results

Synthetic tetrapeptide epitalon restores disturbed neuroendocrine regulation in senescent monkeys.

Khavinson V, Goncharova N, Lapin B

Neuro endocrinology letters1 Aug 2001Cited by 13 (Europe PMC)

PMID11524632 (opens in a new tab)PepBankPUB-11524632
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Summary

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Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

2 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In senescent female rhesus monkeys, Epitalon significantly stimulated evening melatonin synthesis.

    In plain wordsIn old female monkeys, Epitalon increased melatonin production in the evening.

    Peptide
    Epitalon
    Outcome
    IncreaseEvening melatonin synthesis
    Study

    rhesus monkey (Macaca mulatta)n: not reported in source

    Senescent female monkeys
    Outcome group
    Aging markers · Endocrine and hormones
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Epitalon was proven to significantly stimulate melatonin synthesis in senescent monkeys in the evening
    1 context sentence
    Summary · context
    We investigated the character of melatonin and cortisol secretion by immunoferment assay in Epitalon-administered female Macaca mulatta in different age periods.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In senescent female rhesus monkeys, Epitalon normalised the circadian rhythm of cortisol secretion, in connection with stimulated evening melatonin synthesis.

    In plain wordsIn old female monkeys, Epitalon restored the daily rhythm of the stress hormone cortisol.

    Peptide
    Epitalon
    Outcome
    Not applicableCircadian rhythm of cortisol secretion
    Study

    rhesus monkey (Macaca mulatta)n: not reported in source

    Senescent female monkeys
    Outcome group
    Aging markers · Endocrine and hormones
    Studied dose
    Dose not stated

    Source sentences

    Summary
    thereby normalising the circadian rhythm of cortisol secretion.
    1 context sentence
    Summary · context
    We investigated the character of melatonin and cortisol secretion by immunoferment assay in Epitalon-administered female Macaca mulatta in different age periods.

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    9 Oct 2026, 18:17 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:47 UTC

    First added · source update from Europe PMC

Subjects

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