Granulosa cells of the cumulus oophorus are different from mural granulosa cells in their response to gonadotrophins and IGF-I.

Khamsi F, Roberge S

The Journal of endocrinology1 Sept 2001Cited by 29 (Europe PMC)

PMID11524236DOI10.1677/joe.0.1700565PepBankPUB-11524236

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Efficacy outcome
In immature rats, in vivo LR3-IGF-I infusion increased the replication of mural granulosa cells.
In plain wordsIn immature rats, an IGF-I analogue increased the replication of mural granulosa cells from the ovary.
Peptide
IGF-1 LR3
Outcome
IncreaseMural granulosa cell replication
Study
ratn: not reported in source
granulosa cells (cumulus and mural) from immature rats infused in vivo
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
Dose not stated · infusion by pump · 24-29 days of ageAs given in this study (rat).
Source sentences
Summary
The IGF-I analogue had a positive effect on cell replication of MGC but a negative effect on the cell replication of CC.
2 context sentences(design, population, supporting numbers)
Summary · context
Immature rats received saline, equine chorionic gonadotrophin (eCG), LR3-IGF-I or eCG plus LR3-IGF-I by infusion using a pump from 24-29 days of age.
Summary · context
Cell replication was assessed by 3H-thymidine incorporation and differentiation was evaluated by the measurement of progesterone secretion.
Report a problemFND-1152423601
02AnimalAnimal study (in vivo)Efficacy outcome
In immature rats, in vivo LR3-IGF-I infusion decreased the replication of cumulus cells.
In plain wordsIn immature rats, an IGF-I analogue decreased the replication of cumulus cells from the ovary.
Peptide
IGF-1 LR3
Outcome
DecreaseCumulus cell replication
Study
ratn: not reported in source
granulosa cells (cumulus and mural) from immature rats infused in vivo
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
Dose not stated · infusion by pump · 24-29 days of ageAs given in this study (rat).
Source sentences
Summary
The IGF-I analogue had a positive effect on cell replication of MGC but a negative effect on the cell replication of CC.
2 context sentences(design, population, supporting numbers)
Summary · context
Immature rats received saline, equine chorionic gonadotrophin (eCG), LR3-IGF-I or eCG plus LR3-IGF-I by infusion using a pump from 24-29 days of age.
Summary · context
Cell replication was assessed by 3H-thymidine incorporation and differentiation was evaluated by the measurement of progesterone secretion.
Report a problemFND-1152423602
03AnimalAnimal study (in vivo)Efficacy outcome
In immature rats, in vivo LR3-IGF-I infusion increased progesterone secretion by mural granulosa cells.
In plain wordsIn immature rats, an IGF-I analogue increased progesterone secretion by mural granulosa cells.
Peptide
IGF-1 LR3
Outcome
IncreaseProgesterone secretion by mural granulosa cells
Study
ratn: not reported in source
granulosa cells (cumulus and mural) from immature rats infused in vivo
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
Dose not stated · infusion by pump · 24-29 days of ageAs given in this study (rat).
Source sentences
Summary
With respect to progesterone secretion, the IGF-I analogue had a negative effect on CC but a positive effect on MGC.
2 context sentences(design, population, supporting numbers)
Summary · context
Immature rats received saline, equine chorionic gonadotrophin (eCG), LR3-IGF-I or eCG plus LR3-IGF-I by infusion using a pump from 24-29 days of age.
Summary · context
Cell replication was assessed by 3H-thymidine incorporation and differentiation was evaluated by the measurement of progesterone secretion.
Report a problemFND-1152423603
04AnimalAnimal study (in vivo)Efficacy outcome
In immature rats, in vivo LR3-IGF-I infusion decreased progesterone secretion by cumulus cells.
In plain wordsIn immature rats, an IGF-I analogue decreased progesterone secretion by cumulus cells.
Peptide
IGF-1 LR3
Outcome
DecreaseProgesterone secretion by cumulus cells
Study
ratn: not reported in source
granulosa cells (cumulus and mural) from immature rats infused in vivo
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
Dose not stated · infusion by pump · 24-29 days of ageAs given in this study (rat).
Source sentences
Summary
With respect to progesterone secretion, the IGF-I analogue had a negative effect on CC but a positive effect on MGC.
2 context sentences(design, population, supporting numbers)
Summary · context
Immature rats received saline, equine chorionic gonadotrophin (eCG), LR3-IGF-I or eCG plus LR3-IGF-I by infusion using a pump from 24-29 days of age.
Summary · context
Cell replication was assessed by 3H-thymidine incorporation and differentiation was evaluated by the measurement of progesterone secretion.
Report a problemFND-1152423604

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
13 Oct 2026, 21:44 UTC
Study results updated
Version 1
13 Oct 2026, 16:31 UTC
First added · source update from Europe PMC

Subjects

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